Tag Archives: Ken Washenik

Aderans Research and Clinical Trials in Stem Cell Hair Regrowth Technology

Aderans Research [ARI] is a subsidiary of two companies interested in the development of resolving the issues of hair loss from a number of differing causes including medical treatments for cancer, genetic disturbances and inheritors, and injuries resulting in damage to hair follicles such as burns or wounds. Aderans Research is located in Atlanta, Ga. The parent company, Aderans Co., LTD is located in Beverly Hills working in conjunction with Bosley hair treatment and clinics.

ARI is in the second phase of developing cellular restoration products for hair regrowth applications. In November 2011, Aderans announced that it was opening new facilities for additional clinical trials in association with Radiant Research in four new cities across the nation. Some clinics are still accepting people who wish to participate in the study. To date, over 356 individuals have been joined the study as clinical subjects.

Aderans’ research develops rejuvenation using a subjects own hair stem cells eliminating the need for concerns about rejection. By cultivating stem cells from the subject, other complications such as infections or disease transmission is dramatically reduced. ARI studies include both regeneration of hair cells at the follicular level for both men and women.

A stem cell is any cell from any part of the body – skin, brain, fatty tissue, hair, or organs – which has the ability to replicate itself. This process is much like the stem of a plant which sprouts leaves along its length. These cells are one part of the ingredient in hair regeneration. The second part is the cell that acts an alarm clock waking dormant cells.

It has been known since the University of Pennsylvania’s study in 2004 that hair follicles include multiple cells. Some of these cells are hair replication cells, which control cyclical growth of hair. Other cells are communicator cells, which are necessary to wake the dormant cells when it is time for them to grow. People with certain types of hair loss are now known to lack the alarm clock cells. Unless there is a method to inform the dormant cells that it is time to activate, hairs are not generated.

In a Yale University research program, it was discovered that the communication cells, which instruct the hair cells to grow, is found in the fatty layer below the epidermis. The complete ramifications of the results are still not clear but hopes remain strong that this will lead to the ability of medical research to replicate other cells in the human body. Until this time, the value of the fatty layer was not understood.

With the latest breakthroughs in molecular endocrinology regarding communicator cells in the fatty layer beneath the skin and Yale Research in the importance of fat cells for hair growth, Aderans has developed products that are addressing these issues. However, this does not address issues with an underlying cause related to the contraction of hair follicles.

One of the major problems that medical transplants observed was the patchy effect of surgical transplants. The question of why one area of the scalp would allow hair regrowth while another in close proximity would not could not be explained. The Yale and University of Penn studies shed light on this problem. With that, researchers around the world have been working to develop methods to overcome the problem.

During Phase I conducted in the U.K., Aderans research has focused on pattern redistribution issues noted in traditional surgical transplants and medical treatments for regrowth. One of the problems documented was the limitation of distribution of hair regrowth in surgical transplants.

The process used by Aderans involves the reproduction or replication of hair cells taken from a subject. By removing hair samples from the subjects scalp, the stem cells from the follicle are stripped out and placed in a medium that incubates the cells. The medium contains nutrients that are necessary for the cells to replicate on their own. In this way, there are an unlimited number of hair follicles to replant in the subjects scalp. In addition, the fat cells that are a necessary part of the continuation of hair growth develop simultaneously during replication due to the medium used.

Part of the medium used by Aderans is a small amount of tissue removed from the nape of the subject’s neck. By using this method, the fat cells become an integral part of the cloning process and compatible with the subject. This tissue used with Wnt proteins stimulates the replication system of the cells in a natural way.

In January 2012, Dr. Ken Washenik participated as a presenter for the 2012 Winter Dermatology Conference in Maui. Speaking on “Emerging Therapies for Hair Loss,” Dr. Washenik discussed the treatments and new breakthroughs of molecular dermatology as well as the latest advances in Aderans’ Ji Gami product line. He stressed the advance in products still in the pipeline that are proving to be consistently stable.

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Aderans Research and the Most Innovative Treatment for Baldness Available Now

Aderans Research is pioneering what could end up being the most innovative treatment for baldness to come along in a century. Unlike most other companies researching male hair loss and women thinning hair, Aderans is concentrating on a technology that uses a patient’s own cells (known as autologous cells) to develop a virtually limitless amount of new hair follicles. This will obviously be a very expensive treatment for baldness because it will be, in a sense, customized for each patient.

Aderans calls the technology it is developing the Ji Gami™ process. Here’s how it works. Technicians remove a small piece of hair follicle tissue from a patient’s scalp, generally near the neckline. The hair follicle cells are then cultured in a laboratory so that they multiply. When a sufficient amount of new cells have been grown, the hair follicle cells — each unique to the individual patient — are then injected into the bald or thinning areas of the patient’s scalp.

Aderans executives believe they are on the verge of a true cure for baldness, a treatment for hair that will result in almost unlimited new hair growth. This approach is not the same as those attempting to use growth factor serums to regenerate existing dormant hair follicles. Instead, Aderans is attempting to grow new follicle cells, made from cells taken from the patient’s own scalp, and inject them into balding areas for hair growth.

How is the research proceeding? At the moment, Aderans is completing its Phase II clinical testing of its hair fall remedies. A total of more than 350 hair loss sufferers are now enrolled in the clinical trial from cities across the country. At the 2012 Winter Clinical Dermatology Conference in Maui in January, Aderans CEO Dr. Ken Washenik (M.D. & Ph.D.) presented a paper on “Emerging Therapies for Hair Loss” that received a standing ovation from the assembled dermatologists and hair restoration doctors. That’s because Dr. Washenik reported that the Clinical Trials of the Ji Gami™ process are going very well. While the process is not a magic pill that provides install hair like a Chia Pet, it does appear to grow new hair where none existed before — and, what’s more, can provide a virtually limitless supply of donor hair follicles for hair restoration doctors to use. In earlier tests, released in 2010, Aderans reported that more than half of participants in its clinical study showed “significant hair growth” one year after the cell product treatment was administered.

If you’d like to read more technical information about the early developments of this technology, then click on the link below for a PDF…

Bioengineering the Hair Follicle: Fringe Benefits of Stem Cell Technology

The Aderans “cell engineering” approach appears to be the most promising treatment for baldness on the horizon at the moment, according to the company’s spokesman, Vern Liebmann. That’s because the cell engineering approach offers hope for bald men who do not have enough donor hair for a cosmetically satisfying traditional hair transplant. With a limitless amount of donor hair follicles, the Aderans hair treatment could cover virtually any scalp with thick, natural hair.

If you’d like more information about Aderans and its clinical trials, fill in the form below:

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