Author Archives: SCBCADMIN

L’Oreal’s Kérastase Densifique Uses Stemoxydine to Stimulate New Hair Growth

What Is Kérastase Densifique?

L’Oreal is at it again and the company recently released a hair care product which is said to revive dormant hair cells.

Kérastase Densifique is the newest and most talked about hair loss product in the market.

It is said that the product could reverse hair loss and thinning problems.

Demand for Kérastase Densifique is surging and salons have already pre-orders their bottles of the hair solution which is to be used for a recommended period of thee months. The cost of the entire treatment is certainly not cheap as it costs about £300, which translates to about $475.

Does Kérastase Densifique Work?

There have been many products which have been touted as the ‘new and revolutionary’ hair loss revival treatments, most of them have performed dismally. Most of the hair loss products in the market rarely produce desirable results. So what makes Kérastase Densifique different from the rest?

Well, L’Oreal has used stem cell technology with the product. As you are already aware of, stem cell products have been on the increase and this is because the treatment focuses on regenerative therapy.

The idea behind Kérastase Densifique is to act as a stem cell based treatment to revert baldness and hair thinning. According to L’Oreal head of scientific affairs Patricia Pineau, the cosmetic product respects the natural regeneration of hair which is why it is so efficient.

The main ingredient in Kérastase Densifique is stemoxydine which is a molecule that attempts to increase the level of oxygen in the scalp. Hair loss and balding are conditions that have been attributed to oxygen deficiency and with an increase in the oxygen levels, hair growth is a possibility.

Kérastase Densifique therefore aims to increase the production of hair follicles within the scalp and as a result encourage hair growth in parts of the scalp where follicles may have become dormant. The result is thicker hair.

Kérastase Densifique’s Clinical Study of Hair Growth with Stemoxydine

The average human hosts 100,000 to 150,000 hairs in the scalp.

Kérastase Densifique claims to assist in the natural production of hair follicles as opposed to disrupt it which is what many hair products do. A clinical study using a solution of 5 percent stemoxydine produced an increase of 4 percent in the hair density of 101 subjects. 4 percent hair increase represents an increase of about 1700 hairs. During the study, the solution was applied on the scalp once a day for three months and it was conducted on both men and women within the age groups of 18 and 55 years.

The results of the study are very encouraging considering that there are very few clinically proven hair loss products in the market. It is still not clear if Kérastase Densifique has been approved by the Food and Drug Administration (FDA) or licensed by the Medicines and Healthcare Regulatory Agency (MHRA).

According to L’Oreal, the demand for Kérastase Densifique is high, and while the three month treatment is being sold in selected salons and online stores, pre-orders are in the thousands. Many people are indeed ready to try out the product which can regenerate hair growth to a count of over 1500 new hairs.

Kérastase Densifique’s effectiveness is being credited on the stem cells ability to reach areas within the scalp that are susceptible to hair loss. Most hair loss products target hair fibers as opposed to the scalp.

As mentioned earlier, hair loss and thinning are brought about by lack of sufficient oxygen within the scalp. Kérastase Densifique therefore provides a viable solution to a problem that affects millions of people. Kérastase Densifique is currently being sold in Europe but orders can be made from the UK and U.S.

If you would like to get more information on Kérastase Densifique, simply fill in your email address below:

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Treating Hair Loss with Women Hair Loss Products

Hair loss is quite common, especially in aging women. The American Hair Loss Association tells that about 80 percent of women experience hair loss by the age of 60. Hair loss is known clinically as alopecia and it’s important to remember that not all forms of hair loss are cause for concern. The average healthy person sheds as many as 100 hairs a day. However, if you notice that you are shedding more hair than normal its best to visit a dermatologist.

Hair loss is brought about by various factors and age, heredity, hormonal changes, stress, smoking, poor diet, as well as some of the hair care practices we employ could be responsible. Luckily there is something you can do about your hair loss and there are various women hair loss products that you can use.

What Should You Consider When Choosing Women Hair Loss Products?

The hair loss products you choose to use should be largely dependent on the cause of the extremity hair loss and that nature of the loss as well. You also need to keep in mind factors such as the type of medication you are receiving, if any. There is no shortage of hair loss products for women and you can choose those made using natural ingredients. These products are usually labeled as organic or herbal products. You could also go for the ingredients with chemicals. Women hair loss products range from shampoos to conditioners, hair oils, treatments and supplements. Due to the fact that there are so many hair loss products, choosing the right one for you can be daunting task.

The first thing you need to do is seek medical advice from a dermatologist. One of the major reasons why so many women fail to treat their hair loss successfully is because they simply buy products without proper diagnosis. Knowing and treating the cause of the hair loss will definitely help you find an effective situation.
Like we mentioned the nature of the hair loss and its severity matter. While over-the-counter products work great, sometimes you may require prescription hair loss products. This is especially the case in severe cases of hair loss.

You also might want to consider the end results in mind. You must remember that the average rate of hair growth can be quite slow and regaining your full head of hair could take anything between two to five years. Women hair loss products that promise you overnight hair growth are not worth trusting.

What Are The Different Types of Women Hair Loss Products Available?

Hair Growth Shampoos & Conditioners: Shampoos and conditioners that strengthen the hair are essential since they prevent hair loss. It also helps to stimulate blood circulation by massaging the head while cleaning it and you can also exfoliate the scalp with a scrub.

Supplements: There are various hair loss supplements in the market and these include: vitamins such as biotin, calcium and iron. Saw palmetto, stinging nettle, horsetail and pygeum are other supplements that are said to contain powerful nutrients that slow down hair loss. High quality, low cost supplements that help with hair loss (saw palmetto) are available online at www.powdercity.com.

Herbs: There are countless herbal remedies in the market that you can use to boost the re-growth of your hair. Ensure that you first seek your dermatologists go ahead before trying out any herbal remedies or products.

Hair Growth Oils: There are a good number of hair oils that help in treating hair loss and these contain ingredients such as biotin, essential oils like as castor oil, silica, keratin and many more.

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Can stem cell hair loss products give you 1,000 new hairs?

What if hair loss products could grow 1,000 new hairs on your head? Would you be interested?

Well, that’s one of the claims that has been made for a stem cell approach to treating hair loss: 1,000 new hairs.

But before you run out and sign up, consider this: The average adult has approximately 100,000 to 150,000 hair follicles on his or her head and up to 5 million follicles on the entire body. (Yes, there are some variations between men and women.) But the point is this: 1,000 new hairs, while exciting, will not cover your head. It’s a start, but not enough for a cosmetically pleasing result.

We’ve recently posted on our site a very exciting research paper on stem cell treatments for hair loss. It’s the ground-breaking research that discovered that the hair follicles in bald men are not “dead” but only dormant… and that the trick to slowing down and reversing hair loss is to give these stem cells the chemicals signals they need (known as growth factors) to, in a sense, wake up. Click on the link below to read the paper…

Bald scalp in men with androgenetic alopecia
retains hair follicle stem cells but lacks
CD200-rich and CD34-positive hair follicle
progenitor cells

As for practicalities, right now there are only two ways to use this breakthrough research for yourself: (1) Sign up for a clinical trial for experimental stem cell treatments at research laboratories; or (2) try one of a tiny handful of topical stem cell growth serums that are derived from Human Fibroblast Conditioned Media (HFCM).

Growth factor serums are now being sold that take adult stem cells, usually from fat tissue, and culture them in laboratory media… allowing the stem cells to excrete what are called “growth factors.” It is these growth factors that scientists now believe are the key to reviving dormant stem cells.

However, here’s the big unanswered question: Can the use of TOPICAL growth factor serums penetrate deep enough in the scalp to revive the dormant stem cells? The manufacturers say that they do… and we have heard from delighted customers who claim it definitely has slowed down their hair loss. (We also heard from one customer, a totally bald man, who said it didn’t help him enough to make it worth while. As I said, 1,000 hairs sounds like a lot but, even if true, and I don’t know that it is, that’s not enough to cover a totally bald head.)

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Tricomin Hair Loss Products

Hair loss can be a very devastating experience. What is even worse is the fact that most hair loss products do not seem to be effective and those that are effective only work for a couple of weeks. Most hair loss products also do not have the scientific backing to verify their claims and this is this why the hair loss industry is filled with lots of controversies.

If you are tired of all the hype and are looking for an effective product that will manage your hair loss you might want to consider using Tricomin hair loss products.

Tricomin hair loss products are just some of the few products in the hair growth industry that have scientific backing. Their products use ingredients that have been scientifically proven to stimulate hair growth and one of those is copper peptides. Tricomin is on its own league and it does not need to use potassium channel openers for hair growth like other hair growth products. Instead, Tricomin uses copper peptide technology which reduces hair loss and dramatically increases the density of the hair. Copper peptides improve the health of the scalp and its appearance thus increasing follicle growth.

What Do Clinical Studies Say About Tricomin Hair Loss Products?

Tricomin has undergone various clinical studies. In a vigorous trial undertaken by the FDA, this was one of the few products that actually showed signs of stimulated hair growth. Another clinical study conducted on Tricomin also produced great results. The study which was conducted on 36 men showed positive results in just 24 weeks of using Tricomin twice a day.

In order to understand how Tricomin is able to produce such great results, it’s important that you first understand the whole aspect of hair growth. The scalp goes through two phases and these are the resting phase and growth phase. When the resting phase is long, the hair becomes weak and begins to thin or develop some bald spots. Tricomin works by shortening the follicle resting phase. This means that a larger number of follicles are active and can therefore produce more hair. Directing copper peptides to the follicle’s base nourishes the follicles and activates their production even during their resting phase.

It’s important to note that the clinical studies produced no negative side effects.

Which Tricomin Hair Loss Products Can You Use?

There are three very effective Tricomin hair growth products available and these are:

  • Tricomin Therapy Spray: This hair spray has been designed for thinning hair. The follicle therapy spray has been clinically tested to condition and treat the scalp with a unique blend of minerals, amino acids and other essential ingredients. This is a leave-in treatment that can be applied on wet and dry hair.
  • Tricomin Shampoo: Tricomin shampoo cleanses the scalp and restores the structure the hair follicles so as to reduce thinning.
  • Tricomin Conditioner: This conditioner is used along with the Tricomin shampoo and contains the Triamino copper nutritional complex. The leave-in conditioner moisturizes the hair and conditions it leaving you with healthier and stronger hair.

Using the entire range of Tricomin hair loss products is recommended for best results.

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Columbia University Scientists Announced Brand-New Breakthrough for Hair Loss Treatment

Currently, the standard approach for treating male pattern baldness is follicular unit hair transplantation, commonly referred to as FUT or “hair transplant.” This approach involves a surgical procedure in which healthy hair follicles are taken from a donor site and relocated to an affected area. While effective, this technique is not a cure for hair loss, as hair growth is not restored. Rather, existing hair follicles are redistributed in order to minimize the appearance of thinning hair. Additionally, not everyone is a good candidate for this procedure. Women, for example, tend to undergo a diffuse type of hair loss and suffer from a lack of stable donor sites from which grafts for transplantation can be obtained. Patients in the early stages or with excessive hair loss, patients suffering from scarring alopecia, and patients with hair loss due to burn wounds are also not good candidates for the procedure.

Recently, a research team has reported success in stimulating hair growth using cloned dermal papilla (DP) cells.1 These results have exciting implications for hair loss treatment practices. Rather than having to rely on surgical redistribution of existing hair follicles, treatment in the near future could make use of a patient’s own DP cells to stimulate the production of new hair, as well as rejuvenate hair follicles already in place.

A New Way to Trick Hair Follicles Into Producing More Hair

DP cells are specialized cells that reside within the hair follicle bulb. Among other important functions, DP cells send signals to epithelial stem cells to initiate and promote hair growth, making these cells ideal candidates for use in treating hair loss. The idea of cloning DP cells and using them to initiate hair growth is not new. Until recently, however, attempts to retrieve functional DP cells using standard cloning practices have been unsuccessful. One of the main setbacks encountered was trying to keep cloned cells from reverting back to basic skin cells. Angela Christiano, Ph.D., a professor at Columbia University and one of lead investigators in the current study, explained in an interview with “Men’s Health Online” that shortly after removal from the follicle, the cells could no longer recall that they were DP cells. Their cellular identity had basically been erased.2 DP cells require a number of chemical signals from neighboring cells in order to maintain their ability to stimulate hair growth. 3 Cells that have been removed from their natural environment and grown in culture – a procedural step required in order to increase the number of donor cells – no longer seem to receive these signals. As a result, DP cells revert back to basic skin cells and lose the critical ability to stimulate hair growth.
To solve this problem, the research team headed by Christiano in the United States and Colin Jahoda, M.D., Ph.D. at Durham University in the United Kingdom, took a closer look at what was happening during the cloning procedure. Specifically, they looked at how DP cells behave in culture. Traditional culture conditions yield a 2D matrix of cells that is very different from the natural, 3D environment from which the cells are derived. Previously, it had been shown that DP cells extracted from mice, which aggregate in culture to form 3D clumps or spheres, retain their cellular identity and are able to stimulate hair growth when transplanted back.4 Researchers hypothesized that, by forming aggregates, the cultured mouse cells are creating a microenvironment for themselves that mimicks the conditions from which they were originally obtained.

Hair Cloning May Arrive in 2014 After All!

Taking their cue from this observed behavior, the research team turned their attention to the growth pattern of human DP cells in culture. Unlike the mouse cells, human DP cells grow to form a 2D matrix when cloned. Researchers found a significant difference in the genes that are expressed in these cloned cells and those expressed in the original cells. Armed with this knowledge, they took the DP cells and grew them under conditions that promote 3D spheroid formation, rather than the traditional 2D matrix. By reprogramming the cells’ microenvironment in this way, researchers were now able to grow cells with a gene expression pattern similar to that of the original DP cells. In other words, the cells that grew in spheroids didn’t revert, but retained several of their original features.

Researchers examined the ability of these cultured cells to induce hair follicle growth. Remarkably, they discovered that the human DP cells that grew in spheroids were capable of initiating de novo hair follicle growth. What does this mean? It means that human DP cells can indeed stimulate new hair to grow if they are cloned under the appropriate growth conditions – in 3D spheroids.
The results are compelling and clear. When DP cells were transplanted between the dermal and epidermal layers of human skin grafted onto the backs of mice, five out of the seven DP cell populations were able to induce hair follicle growth. As much as six weeks after induction, hair follicles containing inner root sheaths and hair shafts could be seen growing on the human skin grafts.
Researchers verified their findings by analyzing the DNA of the new follicles. Test results showed that the follicles were, indeed, human and a genetic match with the donor cells, proving that the induced follicle growth was undoubtedly a product of the transplanted DP cells.

Previous studies have shown that human DP cells grown in a 3D environment can retain their growth-induction properties when introduced into mouse epidermal cells.5 This is the first time, however, that it has been demonstrated that cultured DP cells grown in such a way can induce hair follicle growth de novo when transplanted into human dermal layers (albeit human dermal layers that have been grafted onto a mouse.) To be clear, the spheroid-derived cells in this latest study were not implanted into existing hair follicles, mouse or human. All of the resulting hair growth occurred from de novo follicles, and was directed entirely by transplanted DP cells.
The significance of these results is astounding to those with a vested interest in finding a better way to treat or reverse hair loss. This is the first time it has been shown that hair follicle growth can, indeed, be restored. Donor DP cells for procedures based on this technique could come from as little as a few hundred hairs, a vast improvement over the thousands of follicles currently needed for follicular unit hair transplantation. Such an advance would make treatment available to the previously mentioned groups of hair loss sufferers who don’t qualify for hair transplant surgery because they don’t have sufficient donor follicles.

The results of the study were announced in an advanced online communication and will appear in the latest issue of Proceedings of the National Academy of Science. While the findings indicate an important advance in the field of hair loss treatment, researchers caution that there is still some work to be done before human clinical trials can begin. Specifically, the source of certain physical properties of the newly induced hair, such as rate of growth, texture, and color are still unclear. Researchers are confident, however, that answers to these questions aren’t too far off. The announcement is a welcome and exciting one, not just for hair loss sufferers, but for the medical and scientific fields at large.

References
1. Higgins, C.A., et al. (2013) Proc Natl Acad Sci USA (epub ahead of print)
2. Behar, M. (n.d.) Men’s Health. MH Spoghtlight. Web. 26 Oct 2013
3. Rendl, M., et al. (2008) Genes & Dev 22:543-57
4. Inamatsu, M., et al. (1998) J Invest Dermatol 111:767-75
5. Kang, B.M., et al. (2011) J Invest Dermatol 137:232-39

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The true cause of hair loss: The relationship between DHT, stem cells and progenitor cells

A lot of people have emailed us and are asking this simple question: We thought DHT is the primary cause of male and female pattern hair loss. But now all these scientists are saying something about how progenitor cells or malfunctioning stem cells cause baldness. Which is it… DHT or stem cells?

Well, that’s a doozy of a question, so let me try to answer it as best I can.

It’s true, the dominant theory for what causes male and female pattern baldness is a genetic hypersensitivity (like an allergy) to dihydrotestosterone (DHT), a derivative from the male sex hormone testosterone.

Make no mistake: DHT is potent stuff. It causes hair follicles to shrivel up and stop producing new hair. It’s also the hormone that causes benign prostatic hyperplasia, or BPH, also known as an enlarged prostate.

Your body converts testosterone into DHT by means of an enzyme, 5-Alpha-reductase, which comes in two forms.

So, we have three elements in this equation: the male sex hormone testosterone… the enzyme 5-Alpha-reductase… and the product of the two of them, dihydrotestosterone (DHT).

You could try to reduce the amount of DHT by reducing the amount of testosterone in your body, but that has all sorts of negative consequences, such as impotence. You can try to reduce the amount of DHT on your scalp by means of anti-DHT lotions. Or, finally, you can try to block the action of the enzyme 5-Alpha-reductase.

This latter approach is known as 5-Alpha-reductase inhibitors… and these potent drugs, available by prescription only, were first used as a treatment for BHP until patients and doctors noticed the unexpected side effect of reduced hair loss.

So far, so good. But about a year ago, cutting-edge stem cell research threw a monkey wrench into the scientific consensus. Dr. George Cotsarelis at the University of Pennsylvania Medical School discovered that hair follicles in the scalps of bald men are not “dead,” as previously thought, but actually merely dormant. More precisely, Dr. Cotsarelis discovered that the hair follicles of bald men contain as many immature stem cells as healthy hair follicles but these stem cells don’t produce as many mature progenitor cells, also known as “workhorse cells,” that actually produce hair.

The key research question right now is: How do you re-active these dormant stem cells and get them to turn into the progenitor cells that grow hair? That’s the million dollar question (literally). At the moment, it looks like the answer involves chemical signals known as growth factors and cytokines – the key ingredients in products like RegenRXx and Histogen’s upcoming Hair Stimulating Complex – but which growth factors, in which combination, and delivered how?

But before answering that question, there is another one: What is the role DHT plays in this process?

And right now, the best guess seems to be that it is DHT that keeps hair follicle stem cells from growing up and becoming progenitor cells that grow hair. In other words, it’s not so much the hair follicle itself that has a genetic hypersensitivity to DHT but the stem cells in the hair follicles.

So, what are the practical implications of this research?

FIRST, 5-Alpha-reductase inhibitors are still effective although increasingly it looks like the side effects may be worse than we thought.

SECOND, protecting hair follicle stem cells from the baleful effects of DHT may not be as difficult as we thought.

In the fall 2011, scientists at Yale University discovered chemical signals from fat cells can stimulate hair follicle stem cells to “grow up” and become the much-wanted progenitor cells that grow hair.

In an article in the scientific journal Cell, the Yale researchers reported that, at least in mice, a special kind of stem cell found in fat – known as adipose precursor cells – was necessary for hair follicles to produce hair. More specifically, fat stem cells produce chemicals known as platelet-derived growth factors (PDGF), and it is these growth factors that may be the missing “on switch” that tell stem cells in hair follicles to turn into mature progenitor cells that grow hair. That’s one of the reasons why we’re so excited about Cygenx.

In other words: We’re pretty darn close to figure out the chemical mechanism that causes male and female pattern baldness. This is huge!

That’s why, despite all the cynicism you hear on the various hair loss forums – in which many denounce all research and leads as “scams” and con games – the research into stems cell hair treatments is truly moving forward. The problem is that science moves at a snail’s pace… and we’re all understandably impatient.

So, to summarize: It looks increasingly like DHT somehow acts like pixie dust on Peter Pan and keeps hair follicle stem cells from growing up and becoming the progenitor cells that produce hair. The result is that the follicles shrink, the hair gets thinner and thinner and eventually stops growing altogether.

If we can figure out how to counteract that process, and send the hair follicle stem cells the chemical signals they need to restart their engines, so to speak, we may at last have a realistic treatment for hair loss in our lifetimes.

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How to Hair Growth for 2012: 7 Steps to Take Right Now

Hair Fall Remedies – How to Hair Growth for 2012 can be outline in just 7 easy steps.

Step #1: Stop using shampoos with sulfates! Chemical additives in shampoos known as sulfates (sodium laureth sulfate and ammonium laureth sulfate) are what cause the lather most people expect when they use shampoos. Sodium Lareth Sulfate (SLS) is a powerful degreaser that is also used to clean garage floors and car engines. Unfortunately, these chemicals tend to dry out your hair, strip it of its color and, worst of all, may damage delicate hair follicles in people with a genetic predisposition to hair loss. The evidence suggests that sulfates irritate the skin and should only be used sparingly and in small concentrations. The problem is, most people in developed countries wash their hair often and use copious amounts of shampoo. What sucks is that virtually 98% of all commercial shampoos use sulfates. The exception are shampoos designed specifically for people who have their hair dyed. Many brands imply that they are sulfate-free but are not. I personally like the Coloresse brand of volume shampoo “for fine, thin, color-treated hair.” We also recomend the Revita shampoo and Revita.COR conditioner by DS Labs.  Buy it or something like it. Throw all your other shampoos and conditioners in the garbage.

Step #2: Begin taking an advanced hair vitamin such as TRX2 immediately. Research suggests that the top vitamins for hair growth are Biotin, Folic Acid, Vitamin B-6, Zinc Oxide and Pantothenic Acid. In otherwise healthy individuals, nutritional factors appear to play a role in people with persistent increased hair shedding. The role of the essential amino acid, l-lysine in hair loss also appears to be important. In addition, a product such as TRX2 adds powerful metabolic stimulants (Potassium, BCAA, Nicotinic Acid) with a natural energy-generating substance (Carnipure™ tartrate) to promote hair growth on a molecular level. Double-blind data confirm the findings of one study in women with increased hair shedding, where a significant proportion responded to l-lysine and iron supplements. Bottom line: Take a good hair and nail supplement such as those available at Powder City and many other supplement shops.

Step #3: Begin using a laser for hair growth. Low level laser therapy (LLLT) is among the most exciting new options in the treatment of hair loss. European studies have shown that LLLT stops hair loss in 85% of cases and stimulates new hair growth in 55% of cases. As a result, in 2007 the FDA approves the use of LLLT as a treatment for hair loss. A 2009 study of the HairMax Lasercomb found significant improvements in overall hair regrowth were demonstrated in terms of patients’ subjective assessment after 26 weeks of using the product.

Step #4: Use a good anti-DHT topical agent for hair growth. DHT, or dihydrotestosterone, is believed by most experts to be one of the principal causes of hair loss. More precisely, doctors people that people who suffer hair loss may have a genetic hyper-sensitivity (a kind of allergy) to DHT that causes the minaturization of hair follicles that leads, eventually, to hair loss. One strategy for dealing with this problem (at least in men) is the use of an oral medicine that limits DHT throughout your entire system. However, this approach has drawbacks because there is some evidence that some men can experience negative side effects from many hair fall remedies, such as impotence. Another approach, therefore, is to use anti-DHT topical agents directly on the scalp… and this has shown some success.

Step #6: Consider using a dermaroller with a doctor’s supervision. A doctor’s supervision is required because of the possible risk of infection in the scalp. In recent trials, over a 3 month period men treated with a dermaroller experienced an increase in hair growth. Some experts warn against this. Talk to your doctor. We do not recommend anyone use a dermaroller (which puts tiny holes in your scalp) without consulting a physician first.

Step #7:  Try Spectral.DNC or Spectral.F7 with Astressin-B.  These are two of the very latest hair growth products on the market.  Do some research on the Internet and you’ll find they are both highly regarded — a bit experimental, and no results guaranteed, but a lot of people seem happy with both of these products.  Another product that many people are experimenting with is Cygenx’s RegenRXx growth factor serum, derived from human stem cells.  As with all stem cell treatments, the goal with RegenRXx is to release chemical signals into the scalp to turn the dormant hair follicles (which are dormant and not dead) back on, to wake them up again, so they begin producing hair.

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RepliCel Now Accepting Applications for Upcoming Clinical Trials of Hair Cloning Technology

RepliCel™ Life Sciences, based in Vancouver, British Columbia, is currently accepting the names of people interested in maybe participating in the next round of its clinical trials of its new hair cloning treatment. Its current Phase I/IIa clinical trials, being conducted in Georgia, are scheduled to end in April 2012.

Replical’s hair regeneration technology involves the harvesting and multiplication of what are called dermal sheath cup (DSC) cells located in a “bulb” at the base of the hair follicle.

In laboratory studies, RepliCel™ scientists have found that DSC cells both stimulate the development of mature hair follicles and the creation of new ones. The scientists discovered that the DSC cells are capable of actually regrowing the dermal papilla and hair follicles themselves.

The way the treatment works is this. Trained technicians harvest DSC cells at locations in the base of the neck, where they are plentiful. These harvested DSC cells are then placed in a special nutrient medium in a laboratory where they multiply.

Once there are a sufficient number of DSC cells taken from a patient’s own neck hairs, the new cells are injected directly into the scalp where hair loss has occurred. Like reseeding a lawn, the DSC cells “migrate” to hair papilla that already exist and effect an regenerative transformation. They also create brand-new hair follicles.

Most importantly, the harvested DSC cells are taken from hair follicles, at the base of the head near the neck, that are not as sensitive to male sex hormones (androgens) which, scientists believe, are what cause the hair follicle miniaturization that makes hair loss happen in the first place.

Also, because the DSC cells come from the patient’s own body, rejection of the cells is far less likely.

RepliCel™ is now accepting queries from individuals who might be interested in participating in its new round of clinical trials. If you’d like more information about possibly participating in its new Phase I/IIa clinical trial of its hair regeneration technology, fill in the form below:

iGrow Hair Growth System Uses Lasers to Grow Thicker Hair

The iGrow hair growth system has been released for 2013-2014, which claims to revolutionize the way hair is grown. The developers say that the iGrow will “re-energize” hair follicles so that they will go back to growing hair. The system costs £665, but it will reportedly start to show results in as little as 6 weeks, though the system will take a full 9 months to complete the hair growth process.

About the iGrow Hair Growth System

The iGrow hair growth system is a helmet that is designed to be worn for 25 minutes every day. People that are already suffering from hereditary hair thinning or have already gone bald can use this system to help address their symptoms. The iGrow system does not promise results before nine months, but claim that it can help people start growing hair back as soon as 6-8 months into treatment. Some are concerned over purchasing the machine because it comes with an expensive price tag, but manufacturers note that a full hair transplant would cost £4,000 – £30,000 which is significantly more than what one could expect to pay for a home treatment, particularly one that is said to be just as effective.
The iGrow system is not said to have any side effects, and those that have used it have not reported any kind of discomfort when using the system. The only negative aspect of the iGrow is that users must wear the helmet for 25 minutes at a time, but the system has incorporated an MP3 interface and built-in iPod to help the time pass more quickly. Dr. Thomy Kouremada-Zioga who performs professional hair transplants notes that the form of light treatment used in the iGrow system is safe and has been known to improve the effects of pattern balding or andorgenetic alopecia on both men and women.

How the iGrow Hair Growth System Works

The iGrow hair growth system is based on technology that has been used in a variety of hair management systems for many years. Laser combs using LLLT hair growth technology have been around for many years and are also known to help people re-grow hair in balding areas. The iGrow has simply expanded the idea by encouraging hair growth on a larger area than the comb could manage to treat. Those using a small comb may only notice that areas that were thinning become thicker which may not be a suitable option for many who are seeking out a solution for their hair loss.

The iGrow is not without its critics, however. Some claim that while the iGrow can make thin hair look thicker, it is not necessarily capable of reversing baldness that has already set in. Hair loss can be caused by a variety of conditions, and not all can be treated equally. Doctors recommend that those interested in the iGrow make the effort to talk with their doctor to determine if this could be used as a long term hair growth solution or if this laser treatment is not designed for the type of hair loss they suffer.

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Alpecin and Caffeine as a Treatment for Baldness and Hair Loss

A number of readers have asked us about Alpecin, the German hair-loss product made up of potent amounts of caffeine. Alpecin is not officially sold in the United States (presumably due to the U.S. Food and Drug Administration) – although it is available online in Canada and even on Amazon.com.

There are two primary products: Alpecin caffeine shampoo and a more potent Alpecin liquid.

We don’t recommend Alpecin primarily because we believe that you can get whatever benefits there are from caffeine through the Revita.COR conditioner which we promote – along with a dozen other DHT-blocking and hair-stimulating ingredients, such as Copper Tri-peptides, Arginine, Encapsulated Cultured Plant Stem Cells, and others.

The question is: What role does caffeine play in slowing or reversing hair loss?

Anecdotally, there are a lot of people who swear by Alpecin… and some of the research we’ve seen is intriguing.

One 2007 study, in the International Journal of Dermatology, looked at the effects of testosterone and caffeine on hair follicle growth. The application of just a tiny amount of testosterone (5 µg/m) suppressed follicle growth… while the addition of small amounts of caffeine (in concentrations of 0.001% and 0.005%) immediately counteracted this effect. Not only that, but the application of caffeine alone significantly stimulated new hair growth.

The authors concluded, therefore, that caffeine is “a stimulator of human hair growth in vitro” and should be studied as a possible treatment for androgenetic alopecia (AGA) or pattern baldness.

Another study, “Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation,” published in 2007 in the journal Skin Pharmacology and Physiology and available here, found that the caffeine in caffeine shampoos (such as Alpecin) definitely penetrates the into the stratum corneum of the scalp and into the hair follicles.

The studies presented by the company that manufactures Alpecin seem impressive, but most are small and not conducted under rigorous conditions. One, conducted at the Catholic University of the Sacred Heart in Rome, found that 82.5% of test subjects saw significant improvement in hair loss after just two months of using the Alpecin liquid.

At the very least, Alpecin and caffeine generally deserves far more study as a hair follicle stimulant.

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