Tag Archives: stem cell hair growth

New Study Shows Histogen’s Hair Stimulating Complex Produces 20% More Hair

Histogen’s Hair Stimulating Complex (HSC) is one of the most widely anticipated hair loss products in the hair loss industry. Both women and men who suffer from hair loss have been waiting for literally years for this product to hit the market – and after years of delays and lawsuits, it’s now completing its clinical trials.

In late October, Histogen CEO Gail K. Naughton finally presented the results of the company’s double-blind Phase I/II clinical trial at the International Society of Hair Restoration Surgery (ISHRS) annual meeting in the Bahamas. The title of her paper was, “Scalp Injection of Active Embryonic-like Cell-secreted Proteins and Growth Factors.”

The results appeared to be exciting but not revolutionary. Naughton reported a very favorable 86% response rate from patients tested. What’s more, she reported that the increase in total hair count was substantially above an earlier trial.

Yet the actual results probably won’t result in a new head of hair for bald men — a mean increase of 39% in terminal hairs and 19.4% in total hair count in this age group in the current trial. The doctor in the video posted above is unimpressed. But like most hair restoration surgeons, this doctor has a vested interest in dissing non-surgical methods of treating hair loss. Still, I think his comments are interesting and well worth hearing. (When will these companies stop playing games with lighting, for example? We’re all on to that!)

Now, 20% more hair will appeal to many people… if that is what it means. Whether this will be a viable treatment for men and women suffering from genetic pattern baldness, however, remains to be seen.

Naughton stressed that the Histogen product produced results in all age groups, not just among the young in early stages of hair loss. What’s more, it appears to be effective in all areas of the scalp, including places not normally responsive to hair loss products.

The trial was small. Fifty six men suffering from male pattern baldness were given injections of Hair Stimulating Complex – a proprietary formula of growth factors. Histogen describes HSC was being made up of “the products of cells grown under simulated embryonic conditions” – which probably means growth factors and cytokines produced by stem cells.

In this, HSC seems similar to other growth factor serums on the market, such as Cygenx’s RegenRXx, only that HSC has to be injected under the skin in a clinic.

Still no word yet on when Histogen’s Hair Stimulating Complex will be available to the general public. Stay tuned!

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The Shocking Truth About Follica’s Hair Follicle Neogenesis

Follica (not to be confused with the hair products store Folica) is a research and development company specializing in epithelial stem cell regenerative biology. These techniques came about because of the years of scientific breakthrough documented by Cheng-Ming Chuong in 2007.

Founded in 2006, Follica is a subsidiary of Pure Tech Ventures in Boston, Ma. Pure Tech Ventures is an investment firm identifying scientific breakthroughs and supporting the research in order to develop new biotech methodologies for medical applications.

Dr. Chuong’s research originally focused on ways to help heal severe wounds from battle to burns. In his lab, he had experimented with several techniques designed to heal deep wounds that went below the epidermis and were splayed open. After years of almost successes, he used a technique discovered by other researchers that showed regeneration of hair follicles. He had no particular reason to believe that such methodology would be successful in his study but expected that he would be able to eliminate one more route.

As is true in nearly all cases, scientists do not operate in a vacuum and attempt new concepts without some stimulus from another research preceding it. In this case, Dr. George Cotsarelis used Dr. Chuong’s information and redirected his own interests. Dr. Cotsarelis discovered that traumatic disruption of the skin under certain circumstances is able to regenerate spontaneously.
In the 50s and 60s, there were sporadic reports of this self-regeneration connected with wound healing during the Korean War and after. With the lack of knowledge on the part of the scientific community about molecular biological structures, about the genetic composition of all life, and the existence of stem cells, the incident reports were shelved.

In the interim, science has caught up with the nature of biological structuring. With nanotechnology on the rise, many new identifiers are being shared across the scientific world. Dr. George Cotsarelis was able to demonstrate manipulative techniques that worked consistently to regenerate hair growth in damaged skin.

By manipulating the key signaling pathways that communicate follicle formation, Dr. Cotsarelis and Dr. Chuong were able to prove what until then had been no more than a theory. There are several pathways and several methods of manipulation that have been discovered. Some companies are using drug compounds in order to wake up sleeping stem cells within the fatty layer of tissue beneath the skin. Follica is taking a different approach. Instead of regeneration, Follica is researching multiple schemes of neogenesis – regenerating hair and skin cells where none exists.

Rather than waking dormant cells that are present, Follica is studying methods of developing new cells that had previously been destroyed. One of the newest patents that Follica has applied for includes Lithium treatments there have been research studies over the last 25 – 30 years that reveal a specific form of lithium when used in treatments for skin regeneration have shown a modicum of success. Whether this is what Follica is doing with their patent is not able to be confirmed.

Rather than referring to Follica as hair regeneration, it should be called by the term Dr. Chuong applied to it 2009 – hair engineering. This method focuses on morphogenesis – the study of how cells are assembled into functional forms. It is through this basic understanding of cell formation and assignment of what those cells are designed to do leads to a more complete understanding of how skin cells and hair follicles are able to regenerate on their own.

One of the most important discoveries by Dr. Chuong was that by tuning the balanced activity of a molecular pathway, it becomes possible to alter the shape, size and number of the ectodermal organs … skin cells.

Another exciting development in the research resulting from studies in hair loss regeneration involves the understanding of the cells in the fat layer of the skin. This research was reported by Yale University in the fall of 2011. What these researchers discovered was that without fat cells hair will not grow. Prior to this study, little credit was given to fat cells beyond the need to regulate body heat systems. The study has yet to go as far as to confirm that this could be the key to a cure for baldness but hopes in medical endocrinology are high that it will lead to a cure. This Yale Study did emphasize that this is not related to genetic causes for hair loss to their knowledge. It may lead to an understanding in how wounds heal or tumors grow.

Helping people through researching the many ways in which cells interrelate is the current focus of Follica’s mission. In the future, Follica is planning on production of several trademarked products, which are currently undergoing human testing in Asia. A surprising result of this cellular research being done worldwide includes the discovery that loss of hair in the ear, possibly related to some forms of baldness, is connected to hearing loss. Growing hair stem cells in cochlea material could lead to hair regeneration and reversal of baldness.

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Aderans Research and the Most Innovative Treatment for Baldness Available Now

Aderans Research is pioneering what could end up being the most innovative treatment for baldness to come along in a century. Unlike most other companies researching male hair loss and women thinning hair, Aderans is concentrating on a technology that uses a patient’s own cells (known as autologous cells) to develop a virtually limitless amount of new hair follicles. This will obviously be a very expensive treatment for baldness because it will be, in a sense, customized for each patient.

Aderans calls the technology it is developing the Ji Gami™ process. Here’s how it works. Technicians remove a small piece of hair follicle tissue from a patient’s scalp, generally near the neckline. The hair follicle cells are then cultured in a laboratory so that they multiply. When a sufficient amount of new cells have been grown, the hair follicle cells — each unique to the individual patient — are then injected into the bald or thinning areas of the patient’s scalp.

Aderans executives believe they are on the verge of a true cure for baldness, a treatment for hair that will result in almost unlimited new hair growth. This approach is not the same as those attempting to use growth factor serums to regenerate existing dormant hair follicles. Instead, Aderans is attempting to grow new follicle cells, made from cells taken from the patient’s own scalp, and inject them into balding areas for hair growth.

How is the research proceeding? At the moment, Aderans is completing its Phase II clinical testing of its hair fall remedies. A total of more than 350 hair loss sufferers are now enrolled in the clinical trial from cities across the country. At the 2012 Winter Clinical Dermatology Conference in Maui in January, Aderans CEO Dr. Ken Washenik (M.D. & Ph.D.) presented a paper on “Emerging Therapies for Hair Loss” that received a standing ovation from the assembled dermatologists and hair restoration doctors. That’s because Dr. Washenik reported that the Clinical Trials of the Ji Gami™ process are going very well. While the process is not a magic pill that provides install hair like a Chia Pet, it does appear to grow new hair where none existed before — and, what’s more, can provide a virtually limitless supply of donor hair follicles for hair restoration doctors to use. In earlier tests, released in 2010, Aderans reported that more than half of participants in its clinical study showed “significant hair growth” one year after the cell product treatment was administered.

If you’d like to read more technical information about the early developments of this technology, then click on the link below for a PDF…

Bioengineering the Hair Follicle: Fringe Benefits of Stem Cell Technology

The Aderans “cell engineering” approach appears to be the most promising treatment for baldness on the horizon at the moment, according to the company’s spokesman, Vern Liebmann. That’s because the cell engineering approach offers hope for bald men who do not have enough donor hair for a cosmetically satisfying traditional hair transplant. With a limitless amount of donor hair follicles, the Aderans hair treatment could cover virtually any scalp with thick, natural hair.

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