Tag Archives: hair loss products

Have You Heard of Salerm Hair Loss Products?

Salerm is a Spanish hair care brand that has more than 50 years experience in the beauty industry. Salerm hair care products are made using the latest scientific advances and they enhance hair volume, shine and maintain the overall health of your locks. If you have been looking for a hair care product that will deal with your hair loss problems, you should consider giving Salerm hair loss products a try.

Salerm hair loss products can help give your crown a new lease of life. Its products are made using highly effective ingredients which enter deep into the cortex where they work to restore the natural structure of your hair.

Which Salerm Hair Loss Products Can You Use?

There are various Salerm hair loss products that you can use to help treat your hair loss problem. Some of these include:

  • Biokera Intensive Hair Loss Treatment: This Salerm hair loss treatment contains natural ingredients such as Ginkgo biloba, ginseng extract and a selected range of vitamins and amino acids. These ingredients work to nourish and invigorate the hair so as to prevent weakening which is highly responsible for hair loss. This special formula generates a thermo-active environment which removes tension from the hair follicles and speeds up the absorption of the nutrients so as to correctly develop each stand of hair.
  • Biokera Specific Hair Loss Shampoo: This shampoo has been specially formulated to help prevent hair thinning by normalizing the growth cycle of hair. It soothes the scalp and nourishes the hair follicles hence creating an environment where hair can grow in a healthy manner.
  • Biokera Volumizing Spray: This spray is perfect for everyday use as it stimulates the regeneration of hair. The hair spray thickens the hair strands instantly making the hair appear fuller all the while invigorating the hair bulb to accelerate hair growth.
  • Energy Hair Regenerator: This is yet another one of the Salerm hair products that can help your scalp to regenerate healthy hair.
  • Biokera Intensive Specific Hair Loss Lotion: The key ingredient in this hair lotion is Ginkgo biloba extract which protects the hair from falling out by promoting its normal growth.

Why Salerm Hair Loss Products?

Salerm hair loss products are made to enhance hair growth in all types of hair. These products can be used on hair that has been chemically processed, dyed and natural hair as well. There are no restrictions. Salerm not only has one product for hair loss but a whole range. They have provided hair loss products for cleansing the scalp, a treatment to strengthen hair and styling products as well with the volumizing spray. In other words, you do not need to source other products as their range of products will meet all your hair care needs. The products are easily affordable and you do not have to break the bank to purchase any of them.

These Salerm products are made using natural ingredient. This means that unlike other hair care products, they will not damage your hair. Natural extracts are not only safer but also more effective especially when it comes to treating fragile hair.

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The Shocking Truth About Follica’s Hair Follicle Neogenesis

Follica (not to be confused with the hair products store Folica) is a research and development company specializing in epithelial stem cell regenerative biology. These techniques came about because of the years of scientific breakthrough documented by Cheng-Ming Chuong in 2007.

Founded in 2006, Follica is a subsidiary of Pure Tech Ventures in Boston, Ma. Pure Tech Ventures is an investment firm identifying scientific breakthroughs and supporting the research in order to develop new biotech methodologies for medical applications.

Dr. Chuong’s research originally focused on ways to help heal severe wounds from battle to burns. In his lab, he had experimented with several techniques designed to heal deep wounds that went below the epidermis and were splayed open. After years of almost successes, he used a technique discovered by other researchers that showed regeneration of hair follicles. He had no particular reason to believe that such methodology would be successful in his study but expected that he would be able to eliminate one more route.

As is true in nearly all cases, scientists do not operate in a vacuum and attempt new concepts without some stimulus from another research preceding it. In this case, Dr. George Cotsarelis used Dr. Chuong’s information and redirected his own interests. Dr. Cotsarelis discovered that traumatic disruption of the skin under certain circumstances is able to regenerate spontaneously.
In the 50s and 60s, there were sporadic reports of this self-regeneration connected with wound healing during the Korean War and after. With the lack of knowledge on the part of the scientific community about molecular biological structures, about the genetic composition of all life, and the existence of stem cells, the incident reports were shelved.

In the interim, science has caught up with the nature of biological structuring. With nanotechnology on the rise, many new identifiers are being shared across the scientific world. Dr. George Cotsarelis was able to demonstrate manipulative techniques that worked consistently to regenerate hair growth in damaged skin.

By manipulating the key signaling pathways that communicate follicle formation, Dr. Cotsarelis and Dr. Chuong were able to prove what until then had been no more than a theory. There are several pathways and several methods of manipulation that have been discovered. Some companies are using drug compounds in order to wake up sleeping stem cells within the fatty layer of tissue beneath the skin. Follica is taking a different approach. Instead of regeneration, Follica is researching multiple schemes of neogenesis – regenerating hair and skin cells where none exists.

Rather than waking dormant cells that are present, Follica is studying methods of developing new cells that had previously been destroyed. One of the newest patents that Follica has applied for includes Lithium treatments there have been research studies over the last 25 – 30 years that reveal a specific form of lithium when used in treatments for skin regeneration have shown a modicum of success. Whether this is what Follica is doing with their patent is not able to be confirmed.

Rather than referring to Follica as hair regeneration, it should be called by the term Dr. Chuong applied to it 2009 – hair engineering. This method focuses on morphogenesis – the study of how cells are assembled into functional forms. It is through this basic understanding of cell formation and assignment of what those cells are designed to do leads to a more complete understanding of how skin cells and hair follicles are able to regenerate on their own.

One of the most important discoveries by Dr. Chuong was that by tuning the balanced activity of a molecular pathway, it becomes possible to alter the shape, size and number of the ectodermal organs … skin cells.

Another exciting development in the research resulting from studies in hair loss regeneration involves the understanding of the cells in the fat layer of the skin. This research was reported by Yale University in the fall of 2011. What these researchers discovered was that without fat cells hair will not grow. Prior to this study, little credit was given to fat cells beyond the need to regulate body heat systems. The study has yet to go as far as to confirm that this could be the key to a cure for baldness but hopes in medical endocrinology are high that it will lead to a cure. This Yale Study did emphasize that this is not related to genetic causes for hair loss to their knowledge. It may lead to an understanding in how wounds heal or tumors grow.

Helping people through researching the many ways in which cells interrelate is the current focus of Follica’s mission. In the future, Follica is planning on production of several trademarked products, which are currently undergoing human testing in Asia. A surprising result of this cellular research being done worldwide includes the discovery that loss of hair in the ear, possibly related to some forms of baldness, is connected to hearing loss. Growing hair stem cells in cochlea material could lead to hair regeneration and reversal of baldness.

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Preventing Hair Loss with a Korean Seaweed (Grateloupia elliptica)

Research was conducted by scientists at the Institute of Medical Sciences, Jeju National University (Korea) to determine if Grateloupia elliptica, a type of seaweed found on Jeju Island, could prevent hair loss and become a brand-new hair loss product.

Although the causes of the various types of baldness or alopecia are yet to be explored fully, scientific studies have recently established a positive correlation between hair loss and dandruff. It has been found that infection caused by a yeast, Pityrosporum ovale, contributes to certain types of hair loss.

At present, there are only two FDA-approved drugs —- Finasteride and Minoxidil —- in the market that can stimulate hair growth and thus combat symptoms of alopecia. Of these, the former has been shown to cause unpleasant side effects, including impotence. Therefore, its use is increasingly being limited.

Because of this, scientists at the Jeju National University have been attempting to discover new substances that can promote hair growth and thus be used to improve the alopecia condition.

If you would like to read a scientific paper on the potential of Grateloupia elliptica for preventing hair loss, click on the link below:

Hair-Loss Preventing Effect of Grateloupia elliptica

Research Methodology

To carry out the research, scientists collected the seaweed Grateloupia elliptica from the sea coast, washed it thoroughly to remove all traces of sand, salt, and other impurities, and then froze it at -20 degrees C. After grinding this frozen substance, treating it with ethanol, filtering, and finally drying it, the scientists obtained an almost pure form of Grateloupia elliptica that did not contain anti-oxidants like catechin, flavone, quercetin, and rutin that may influence the tests and thus prevent scientists from ascertaining the true effect of the seaweed, the object of their study.

This scientific study was performed on frozen cells derived from rats and mice. The objectives were to test the effects of introducing Grateloupia elliptica extract on dermal papillae cells; the activity of 5?-reductase; the production of PGE2 and cytokine; and its effect on P. ovale.

Results

The blood vessels in the dermal papillae cells nourish hair follicles. Thus regeneration of these cells indicates their improved functioning that in turn may promote the growth of hair. After introducing G. elliptica in various concentrations in the frozen dermal papillae cells of rats, it was found that 100 ?g/ml of G. elliptica brought on close to 170% increase in the number of dermal papillae cells. This indicates that G. elliptica may promote regeneration of hair.

The presence of 5-alpha-reductase in the body facilitates the production of DHT (dihydrotestosterone) from testosterone that leads to hair loss and ensuing conditions of baldness. 5?-reductase inhibitors are known to be anti-androgenic drugs. That is, these have the ability to improve symptoms of androgenetic alopecia (AGA), a common form of the condition that affects both men and women. These drugs work by impeding 5-alpha-reductase activity in the body. In the tests carried out at Jeju National University, it has been noticed that G. elliptica extract impaired 5?-reductase activity in rat cells by as much as 48% when introduced in a concentration of 10 ?g/ml. This finding suggests that G. elliptica may be used in the treatment of AGA.

It is known from previous scientific studies that prostaglandin E2 (PGE2) is a hormone-like substance that can promote hair health and induce new growth. In the current research study, it was found that PGE2 production increased after introducing G. elliptica extract in the cells. This indicates that G. elliptica may have the potential to induce hair growth.

Cytokines released by infected or damaged cells can cause inflammation and chronic inflammation, which, in turn, have been positively linked to hair loss. In the present research study, it has been discovered that G. elliptica extract impairs the activity of cytokines and thus may be used in the treatment of alopecia areata (AA).

Earlier research studies have conclusively shown that a dandruff condition caused by P. ovale infection leads to hair loss and increases the chances of baldness in men and women. The present research study showed that G. elliptica extract impaired the activity of P. ovale and thus has the potentiality to prevent hair loss.

Conclusion

The study carried out by the scientists at Jeju National University is believed to be the first-ever research conducted on the potential of G. elliptica to treat symptoms of alopecia. It has been found that G. elliptica showed greater potentiality to treat alopecia than other seaweeds like Halymeni adilatata, Laurencia pinnata, and Sargassum coreanum.

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Predictions for Hair Loss Products in 2013

Well, another year has come and gone and we STILL don’t have a magic cure for hair loss. These companies keep promising and promising… yet nothing seems to come of their promises. Nevertheless, as someone who has been following stem cell technologies for hair loss since 2008, I can say that there have been breakthroughs and a lot is happening behind the scenes. Here are four hair loss product trends to watch for in 2013:

1. Anti-D2 Products. Earlier in 2012, Dr. George Cotsarelis of the University of Pennsylvania announced the discovery of an enzyme, called prostaglandin D2 (PGD2), that tells hair follicles to stop growing hair. His company, Follica, announced that it was working on a new anti-D2 product that could be a major breakthrough in hair loss. (Advantage: There are already drugs on the market for D2 that are used in asthma.)

2. Bimatoprost. Allergan is currently in clinical studies of the drug bimatoprost (Latisse) which appears to stimulate new hair growth. Results should be reported next year. The best guess is that it will turn out to be an effective treatment for hair loss, particularly for women, but probably along the lines of minoxidil — which helps some people but is not really a “cure.”

3. Histogen. A lot of people are anxiously waiting for Histogen’s Hair Stimulating Complex to finally be released… but it’s still a year or two away at best. Histogen’s product is a proprietary blend of growth factors that are surgically injected into the scalp to stimulate new hair growth.

4. Aderans. Aderans is attempting to develop a true hair cloning technology: Its Ji Gami process removes hair follicle cells from a patient’s neck… cultivates and multiplies new follicle cells in a laboratory… and then attempts to “re-seed” a bald head like a new lawn. The company is now in Phase II clinical trials all across North America. Aderans has said it should release its product in 2014 but we should begin to hear a lot more about it next year.

If I had to guess, I would say that hair cloning will turn out to be the treatment of choice going forward. It will not be a silver bullet but will be more like hair transplant surgery than a lotion. The difference is that, with hair cloning, doctors may yield a more cosmetic pleasing result than what is now possible with limited amounts of donor hair.

So, the question remains: What do hair loss sufferers do until hair cloning arrives? We’ve always said you should try a “kitchen sink” approach. You should visit a medical doctor who specializes in treating hair loss. Ask his or her advice on finasteride and minoxidil. Try some of the anti-DHT shampoos and conditioners on the market, like DS Laboratories Revita and Revita.COR. Try cold laser treatments (certified by the FDA as effective for stimulating hair regrowth). If you have extra cash and are willing to try an experimental treatment, you could try growth factor serums such as RegenRXx or Oxford Biolabs TRX2 (both of which we offer in our products section). You could also find a doctor willing to try Bimatoprost as an off-label treatment, although I would rather wait under the Allergan clinical studies are completed. I honestly believe that you should try to slow down the hair loss as much as possible… because some sort of viable hair cloning treatment may be just around the corner.

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Will New Prostaglandin Creams Be New Hair Loss Products

One of the leading pioneers in researching a stem cell treatment for hair loss, Dr. George Cotsarelis at the University of Pennsylvania’s Perelman Center for Advanced Medicine, just let slip that a new approach to growing new hair could be in the works: A topical cream designed to counteract the effects of a hormone-like substance, known as Prostaglandin D2, that may play a key role in baldness.

In the March 21 issue of Science Translational Medicine, Dr. Cotsarelis reported that his team discovered that Prostaglandin D2 is present in much higher levels in the bald areas of men’s scalp but not present in the hairier areas, such as on the side of the head. Dr. Cotsarelis’s team previously discovered that stem cells in hair follicles are not “dead,” as previously thought, but only dormant… and that something is preventing them from turning into the “progenitor cells” that actually produce hair.

In the past, medical researchers theorized that baldness is due to a genetic hypersensitivity to dihydrotestosterone (DHT). This potent sex hormone is a derivative of testosterone, made by the body with the help of an enzyme, 5-alpha-reductase. In addition to playing a major role in prostate enlargement, DHT also, in some men and women, triggers a miniaturization of the hair follicles in certain areas, causing a gradual thinning of the hair until the follicle ceases to produce any hair at all. One method of treating this is topical creams that remove excess DHT from the scalp. Another is through the prescription drug finasteride (Propecia), originally used to treat enlarged prostates. This drug is known as a 5-alpha-reductase inhibitor because it “inhibits” the action of the enzyme that produces DHT, thus reducing the amount of DHT in someone’s system… and that, in turn, can slow down and even reverse hair loss. Finasteride is effective about 50% of the time, but it comes with some risks: Recent studies warn that it may cause impotence, decreased sex drive and depression.

Now, Dr. Cotsaerlis’s team has thrown another complicating factor into the mix: Prostaglandin D2. The question they were confronting was: What causes the stem cells in hair follicles to become dormant? Is it the lack of something (growth stimuli) or the presence of something (an inhibitor)?

The team analyzed scalp tissue from men undergoing hair transplant surgeries. They discovered no fewer than 81 different genes with higher activity in the balding areas of the scalp compared to the hairier areas, and one of these genes produced Prostaglandin D2. The researchers concluded, therefore, that it was the presence of something, Prostaglandin D2, that was holding back hair growth. (To further complicate matters, however — nothing in science is ever simple — they discovered another prostaglandin, F2alpha, that appears to stimulate the growth of eyelashes.) The researchers tested their hypothesis in the lab with human hair follicles and on bald mice and, sure enough, Prostaglandin D2 definitely caused baldness when they applied it to skin.

Digging deeper, the researchers found that Prostaglandin D2 works on stem cells in combination with another protein, GPR44, which triggers a “biochemical chain reaction” when it encounters Prostaglandin D2. It might be possible, therefore, to develop a drug or cream that eliminates this other protein, GPR44, which renders Prostaglandin D harmless to stem cells in hair follicles.

Further proof that the scientists may be on the right track can be seen by the fact that Minoxidil — along with finasteride one of two drugs approved by the FDA for hair growth — activates an enzyme that produces… yes, you guessed it… prostaglandins!

So, where does all this leave us? What happened to DHT? The scientists’ best guess now is that hair growth is caused by a delicate balance of prostagladins. Prostaglandins are chemical messengers made from fatty acids, similar to hormones, present in every cell in the body. There are at least 16 different major types. It may well turn out that the old medical understanding of what causes baldness — a hypersensitivity to DHT — was correct but just too simplistic. In other words, it may be that what causes hair loss is an imbalance of prostaglandins — too much of one, not enough of another — and that all we have to do is restore that balance and voila! instance hair growth!

The creation in 1997 of a prostaglandin analog, latanoprost, and the subsequent discovery that it stimulates new hair growth in eyelashes, lends some credence to this theory.

Nevertheless, science proceeds at a snail’s pace and everyone associated with this research urges caution. As Yogi Berra put it, “it’s tough to make predictions, especially about the future.”

Dr. Cotsarelis told the BBC recently that the next step in his research is to search for compounds that have an effect on the “receptor” in the stem cells — presumably GPR44 — and then to figure out if blocking this receptor would merely prevent hair loss or could actually reverse it. However, he added that there are “several” drugs already in existence that target this “pathway” and that clinical trials are already underway.

Maddening, isn’t it? They seem to be inching closer and closer to understanding the biochemical basis for hair loss yet remain very far from having a practical, real-world treatment.

Yet we are much closer than we were even just a few years ago. You know what they say: growing old beats the alternative… a learning a little beats learning nothing.

Stay tuned!

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