Wednesday, September 9, 2015
Man, this is big news! As one website put it, “Are bald guys just stressed out?” Do the stress hormones your body releases trigger hair loss? And, more importantly, can a treatment that blocks those stress hormones reverse hair loss?
Those are the million-dollar questions scientists have been asking this past year after an accidental discovery involving stressed-out mice that lost their hair… and then grew it back with an anti-stress hormone:
Scientists studying a gastrointestinal disease recently discovered a medical breakthrough … in hair loss. The resulting treatment, discovered by accident, offers promising results in treatment and prevention of baldness and alopecia.
According to reports, researchers came across the discovery when testing a chemical compound on genetically-altered mice. The mice’s bodies had been programmed to overproduce a stress hormone, called corticotrophin-releasing factor (CRF), which, in addition to other things, caused them to lose their fur as they aged.
As part of the study, the balding mice were given five daily injections of a recently-developed anti-stress hormone, astressin-B, and then returned to their habitat. Three months passed, and when scientists returned to collect the rodents for follow-up studies they unexpectedly discovered the once-hairless subjects had re-grown their fur. Reports indicate the injections were 100 percent effective in re-growing hair.
“Our findings show that a short-duration treatment with this compound causes an astounding long-term hair regrowth in chronically stressed mutant mice,” said Dr Million Mulugeta of the David Geffen School of Medicine at UCLA.
“This molecule also keeps the hair colour (and) prevents the hair from turning grey,” he told the AFP news agency.
”This could open new avenues to treat hair loss in humans,” Dr Mulugeta added.
Here’s how MedPageToday characterizes the research:
The mutant mice bred to overproduce the stress hormone corticotrophin-releasing factor become bald on their backs as they age. But after a week of daily injections with a compound to block CRF — called astressin-B — developed by the group to treat gastrointestinal disease, the mice unexpectedly regrew their missing hair and were indistinguishable from controls.
The effect remained for up to four months, which the researchers pointed out in a press release is a long time in a mouse’s less than two-year life span. It far exceeded the mild regrowth produced by in the same mouse model, the group reported in PLoS One.
Since CRF is also expressed in human skin, the researchers expressed optimism that a similar approach could be a “breakthrough therapy for alopecia.”
And here’s what’s REALLY exciting: The biotech company Divine Skin, Inc., just announced the release of the first topical hair-growth treatment based on astressin-B!
Divine Skin becomes the first biotech developer to synthesize and commercialize the peptide for human use in a cosmetic product, to be marketed as Spectral.F7 under the DS Laboratories brand.
“Astressin-B is a very complex peptide that is difficult to synthesize,” said Divine Skin CEO Daniel Khesin. “So we are especially excited that the resulting product will be reasonably priced as well as cutting-edge, considering the extraordinary development schedule and cost.”
Astressin-B sparked extensive media coverage worldwide and excitement around the biotech industry after a clinical study, conducted by the University of California Los Angeles and the Veterans Administration, was published in February. By applying the peptide (a protein fragment) subcutaneously to mice that had gone bald due to overexpression of stress hormones, scientists showed that astressin-B blocked receptors for corticotropin-releasing factor, involved in the stress response, and led to hair regrowth.
“We think this technology is years ahead of its time,” continued Khesin. “It could provide significant benefits to many of our hair-loss customers. Spectral.F7 is another direct result of our relentless commitment to bring the latest technology to market first and always.”
Spectral.F7, a booster that can be combined with other treatments or used alone, should begin shipping in October. It comes less than two months after Divine Skin introduced Nanoxidil, a new molecule designed to stimulate follicles at the vertex of the scalp and surpass for efficacy and tolerability.
Divine Skin Inc. leads in the development of biotechnology for topical, nutritional, and pharmaceutical therapies. It markets worldwide through online and specialty retailers, cosmetics wholesalers, salons, and medical offices. The fast-growing company went public in 2009. The Before and After photos above are from a study of Spectral.DNC hair growth solution.
We’ve reserved for our readers just one hundred (100) sets of this Spectral.DNC Pack for the low price of just $281.80 (plus $14.95 shipping in the U.S. and Canada, $29 worldwide).
If you’d like to put your name on our “no obligation” interest list to get one of these packs, just fill in the form below. The company will not offer these for sale until it has the new batch of Spectral.F7 in hand, packed and ready to ship. We anticipate delivery around the end of September. When the product is ready to ship, we will let you know how to order, while supplies last. Limit one set per customer.