Losing hair can be particularly embarrassing for women. While this is something no woman wants to endure, it is an all too common problem. There are many causes of female hair loss. Before a woman can begin identifying solutions for attaining a full, healthy head of hair, she needs to understand the many factors that contribute to the loss of hair.

Women often experience hair loss due to variations in their hormone levels. Events such as excessive stress, pregnancy or illness trigger hormonal changes that can result in thinning or balding hair. Often, these changes are gradual, and it takes time for the symptoms of hair loss to become noticeable.

The most common cause of hair loss is the change in hormones that occur post-menopause. According to clinical studies, more than 30 percent of women experience some kind of hair loss during or after menopause when estrogen levels drop. Estrogen blocks androgen receptors, including DHT, or dihydrotestosterone, which is a form of testosterone. When estrogen decreases, the hair follicles become exposed to increased levels of DHT, resulting in a loss of hair.


Weight loss and nutritional deficiencies are also common causes of female hair loss. Like the rest of the body, healthy hair requires adequate nutrition. Undergoing a stressful situation, such as severe weight loss or illness, can put stress on the hair follicles, causing the follicles to begin shedding hair instead of continuing to grow hair.If the body’s immune system becomes weakened, this also affects the growth cycle of hair.

Traction alopecia is hair loss that comes from the constant breakage of hair. Certain types of hairstyles, such as tight braids, can damage the hair. The hair follicle can be injured to the point where hair stops growing or falls out completely. Once the hair follice recovers, hair growth can occur again.

An underactive thyroid should also be investigated as a possible culprit. Symptoms of an underperforming thyroid include dry skin, extreme sensitivity to cold, and hair loss or thinning. Proper medication can relieve the symptoms, including hair loss.

Hair loss after pregnancy is also something many women experience. As the body is adjusting to hormonal changes, the hair follicles are also affected. During these hormonal fluctuations, many women experience increased hair loss while the body is returning to its pre-pregnancy condition, which may take up to a year.

While hair loss for women is less common than it is for men, it still affects many women through a variety of life stages. Understanding the causes of female hair loss is the first step in solving the problem of thinning hair and hair loss. Suffering in silence is not the only option.

Many women look for advanced hair loss products to slow hair thinning and promote new hair growth.

Dear Friend,

Hello. My name is Julian Phillips. Some friends and I started StemCellBaldnessCures.com back in 2008 when the first news reports appeared about new stem cell treatment for hair loss.

At the time, it seemed as though the scientists were on the brink of a treatment for baldness. Since then, we’ve learned that, while the initial research that gave rise to those reports was real and truly revolutionary, the way to a practical, commercial treatment is littered with obstacles.

One of the companies that started the research stem cell treatments for hair loss, Intercytex, went out of business two years later… and another, Histogen, has been involved in court disputes over its technologies that have dragged on for years.

Yet the research is continuing… and is FINALLY beginning to bear fruit.

One of the companies that has been involved in stem cell research for hair loss is Aderans Research, and it is currently deep in its Phase II clinical trials for its new hair cloning technology that, if it works, could result in virtually limitless amounts of donor hair follicles being available for patients. Another company, Replicel Life Sciences of Vancouver, British Columbia, is also in clinical trials of a similar technology: the attempt to extract hair follicle cells from someone’s head, multiply them in a lab, and then re-inject the cells over bald areas of the same person’s scalp, like reseeding a lawn.

This website is dedicated to tracking these developments — and other new technologies and treatments for slowing and reversing hair loss in both men and women. Feel free to browse the links on this site for more information about stem cell and other advance treatments for hair loss, or sign up for our 12-part email course below, where you’ll receive one update per day in your email box.

In this FREE mini-course, you’ll learn:

The breakthrough discovery about hair follicles that is fueling million-dollar research projects…

The 7 steps you can take, right now, to slow hair loss men or women and perhaps even reverse it…

The differences between stem cell treatments, hair cloning, hair multiplication and follicular unit transfer…

What the government isn’t telling you about hair loss drugs that can leave men permanently impotent…

The #1 problem for hair transplant physicians — and why a new technology may eliminate it forever…

What teenage boys can do to stop a receding hairline before it’s too late to reverse it…

Why so many women suffer from thinning hair — and 4 new treatments designed just for them…

Julian Phillips

Webmaster

P.S. You may UNSUBSCRIBE and OPT OUT of any email signup at any time automatically by clicking on the “unsubscribe” link at the bottom of every email sent to you. Alternatively, you may send us an email at unsubscribe@stemcellbaldnesscures.com and we will manually delete your name and email address from our list. You will never hear from us again.

Articles

Biostem Seeks to Expand Its Stem Cell Hair Loss Products Worldwide

Video: Dr. Alan Bauman Uses Combination of Eyelash Growth Serum and Laser Cap to Stimulate New Hair Growth

Replicel Says Its Potentially Revolutionary Hair Cloning Technology Passed Its First Safety Test, Market Unimpressed

Aderans Research and Clinical Trials in Stem Cell Hair Regrowth Technology

Breakthrough: Japanese Scientists Use Stem Cells to Regenerate Hair Follicles in Bald Mice!

Dr. Coen Gho Demonstrates His Hair Stem Cell Transplant Technique in New Video

RepliCel Now Accepting Applications for Upcoming Clinical Trials of Hair Cloning Technology

Will New Prostaglandin Creams Be New Hair Loss Products?

Does Acell Matristem & PRP Result in Genuine Hair Regeneration?

ASHRS Chief: Hair Cloning or Hair Multiplication is Coming

Hair Cloning: RepliCel and the World of Cellular Hair Restoration

Histogen’s Hair Stimulating Complex for Hair Loss, Hair Growth

Recoverup’s Stem Cell Treatment for Hair Loss

The Shocking Truth About Follica’s Hair Follicle Neogenesis

Aderans Research and Clinical Trials in Stem Cell Hair Loss Treatments

What Really Causes Hair Loss: DHT and Hypersensitive Stem Cells that Refuse to Grow Up

Update on Aderans on Hair Cloning Technology

Stem Cell for Hair Loss: Dr. Coen Gho Pioneers Patented Hair Follicle Multiplication and Hair Growth Technologies

Baldness Cure: Replicel Develops Hair Loss Treatment for Cue Ball Heads!

How to Hair Growth for 2012: 7 Steps to Take Right Now

Bald Women: What to Do About Female Hair Loss

Wound healing and hair cloning

Can stem cell hair loss products give you 1,000 new hairs?

Earlier, the company had reported that participants had seen on average growth above 5%.  However, Replicel’s spokesman explained that the averages, especially in such small studies, are often deceptive.  For example, a number of participants actually saw a decrease in the number of hairs as hairs fell out from the trauma of the process itself… only to grow back after the study concluded.  When the scientists looked at the data more closely in recent days, the spokesman said, they noted substantially more growth than they had before.

According to the company, RepliCel’s technology involves the harvesting and implantation of autologous (the patient’s own) hair cells from their own healthy hair follicles. The hair cells are then multiplied in a lab and re-injected into balding parts of the scalp.


RepliCel is one of a number of companies attempting to develop viable hair cloning or follicle multiplication technologies for hair regeneration. The hope is that in the near future hair restoration doctors will be able to “re-seed” a person’s scalp the way gardeners reseed a lawn — and using cells taken from the patient’s own healthy hair follicles. RepliCel says it has won patents for its technology from the European Union and Australia and that other patents are pending in other international jurisdictions.

Stress related hair loss can occur after surgery or a severe illness. It is also associated with the stress of combat or living in a war zone. Others sources of stress include work-level overload and abusive relationships. The human body is a fragile eco-system teetering on the balance of the way in which you live. Hair falling out from stress can be treated using a combination of methods.

The severity of shedding and it’s permanency must first be determined before treatment begins. In some instances, hair falling out from stress is only temporary and will grow back on its own. In either case, the issues of poor nutrition needs to be handled as soon as possible. There are many unique ways to acquire the minerals and nutrients needed. One such way is by using a wider variety of herbs in cooking.


For permanent manifestations of hair falling out from stress, counseling is usually one of the treatments used. Sometimes, such counseling is minimal just to help you deal with the fear associated with the trauma experienced – such as a death in the family. Longer-term emotional counseling is used for those who have disorders such as posttraumatic stress syndrome. In either case, hair loss can be stopped by combining topical treatments.

Another situation where hair falling out from stress occurs is when you live with an abusive situation. This can mean emotional or mental abuse as well as physical confrontation. Often people who live in abusive situations do not realize that this is the case. Abuse happens slowly over a period of time and people adjust to it. One reaction is to attempt to be perfect and not disappoint the other party.

Hair falling out from stress in children nearly always requires some form of emotional counseling. Frequently, the abusive situation is discovered with children who habitually pull, tug or twist their hair to the point that it falls out. Abusive situations are not the only reason for children twisting and pulling their hair, however. Other reasons causing the stress may be the cause.

No amount of nutrition or treatment can change the reason for your stress. But, hair falling out from stress is a serious symptom that there is something medically wrong and deserves your attention to fix it.

Biostem Seeks to Expand Its Stem Cell Hair Loss Products Worldwide

Biostem U.S., which describes itself as a “technology licensing company” with hair regrowth treatment using using human stem cells, is seeking to expand its operations worldwide. The company, a NEvada corporation based in Clearwater, FLorida, recently announced the change of its stock symbol to HAIR. The company offers hair growth treatments that feature a combination of Platelet Rich Plasma (PRP) injections, the user of low level lasers, nutritional supplements and other hair products to stimulate new hair growth. The company is hoping to license its technology to private clinics around the world. Its first clinic outside of the Clearwater area is in Ohio.

Biostem was founded by two hair restoration doctors, Dr. John Satino and board-certified Medical Director Dr. Michael Markou, who work out of the Hair and Scalp Clinics in Clearwater, Florida.


It appears that the technique used by Dr. Satino and Dr. Markou is a variation on a technique used by some other hair restoration doctors around the world, which is to gently “wound” or irritate the scalp and then use injections of concentrated growth factors, taken from Platelet Rich Plasma, to stimulate hair follicle regeneration. Recent research has show that the “healing” process in skin seems to have this stimulating effect. Dr. Satino and Dr. Markou use special CO2 lasers to assist them in the gentle wounding of the scalp. They follow up the PRP process with other proven hair growth treatments, including low level lasers and nutritional supplements.

In addition to patients suffering from male pattern baldness, Dr. Satino and Markou have also used their techniques for patients suffering from alopecia areata and female hair loss.

If you would like additional information about Biostem and other new advanced treatments for hair loss, fill in the form below. You may “unsubscribe” at any time.

Replicel’s hair loss product involves the harvesting of hair cells from a patient’s hair follicles — technically known as autologous dermal sheath cup cells (DSCC) — multiplying them in a laboratory, and then re-injecting the new hair cells in bald areas of the patient’s scalp, like re-seeding a lawn.

The six-month assessment of the technology, the first ever involved human test subjects, was to determine whether the technology was safe so that testing could move on to even larger clinical trials.

There are 19 total test subjects in this trial, nine women and ten men. The researchers found that the injection sites of the participants showed very few signs of bleeding, infections, burning or itching, or the growth of cysts. Instead, the researchers found that the injections of DSCC cells directly into the scalp were well tolerated.


According David Hall, Replicel’s president, the safety findings were essential so the company can proceed with its far more ambitious Phase IIb clinical trials with a larger number of volunteers. Relpicel is currently taking names of people worldwide who might be interested in participating in its next found of clinical testing. (To get more information on these clinical trials, see below.)

The data from this latest assessment also supported the claim that Replicel’s technology is effective as a hair loss product. However, the initial results will no doubt disappoint hair loss sufferers because, while statistically significant, they show only mild hair regrowth. According to the company, total hair density in the areas injected with DSCC cells increased a total of 6.1% from baseline.

More precisely, vellus hair (light whispy hair) density increased approximately 12% and terminal (regular) hair density increased only 3.2%. Company officials, however, were encouraged. Calling the hair growth at DSCC injected areas of the test subjects’ scalps a “significant response,” Darrell Panich, the company vice president, said that RepliCel’s technology fully justified a much larger Phase IIb clinical trial. He added that the new testing will concentrate on “optimum dosing and treatment regimens.”

The announcement of the study’s results does not appear to have helped the company’s stock, however. Relicel Life Sciences (REPCF) was trading around $2.05 a share on May 1 but fell to $1.27 a share at close of trading on May 4 — a loss of 40% in just days.

ARI is in the second phase of developing cellular restoration products for hair regrowth applications. In November 2011, Aderans announced that it was opening new facilities for additional clinical trials in association with Radiant Research in four new cities across the nation. Some clinics are still accepting people who wish to participate in the study. To date, over 356 individuals have been joined the study as clinical subjects.

Aderans’ research develops rejuvenation using a subjects own hair stem cells eliminating the need for concerns about rejection. By cultivating stem cells from the subject, other complications such as infections or disease transmission is dramatically reduced. ARI studies include both regeneration of hair cells at the follicular level for both men and women.


A stem cell is any cell from any part of the body – skin, brain, fatty tissue, hair, or organs – which has the ability to replicate itself. This process is much like the stem of a plant which sprouts leaves along its length. These cells are one part of the ingredient in hair regeneration. The second part is the cell that acts an alarm clock waking dormant cells.

It has been known since the University of Pennsylvania’s study in 2004 that hair follicles include multiple cells. Some of these cells are hair replication cells, which control cyclical growth of hair. Other cells are communicator cells, which are necessary to wake the dormant cells when it is time for them to grow. People with certain types of hair loss are now known to lack the alarm clock cells. Unless there is a method to inform the dormant cells that it is time to activate, hairs are not generated.

In a Yale University research program, it was discovered that the communication cells, which instruct the hair cells to grow, is found in the fatty layer below the epidermis. The complete ramifications of the results are still not clear but hopes remain strong that this will lead to the ability of medical research to replicate other cells in the human body. Until this time, the value of the fatty layer was not understood.

With the latest breakthroughs in molecular endocrinology regarding communicator cells in the fatty layer beneath the skin and Yale Research in the importance of fat cells for hair growth, Aderans has developed products that are addressing these issues. However, this does not address issues with an underlying cause related to the contraction of hair follicles.

One of the major problems that medical transplants observed was the patchy effect of surgical transplants. The question of why one area of the scalp would allow hair regrowth while another in close proximity would not could not be explained. The Yale and University of Penn studies shed light on this problem. With that, researchers around the world have been working to develop methods to overcome the problem.

During Phase I conducted in the U.K., Aderans research has focused on pattern redistribution issues noted in traditional surgical transplants and medical treatments for regrowth. One of the problems documented was the limitation of distribution of hair regrowth in surgical transplants.

The process used by Aderans involves the reproduction or replication of hair cells taken from a subject. By removing hair samples from the subjects scalp, the stem cells from the follicle are stripped out and placed in a medium that incubates the cells. The medium contains nutrients that are necessary for the cells to replicate on their own. In this way, there are an unlimited number of hair follicles to replant in the subjects scalp. In addition, the fat cells that are a necessary part of the continuation of hair growth develop simultaneously during replication due to the medium used.

Part of the medium used by Aderans is a small amount of tissue removed from the nape of the subject’s neck. By using this method, the fat cells become an integral part of the cloning process and compatible with the subject. This tissue used with Wnt proteins stimulates the replication system of the cells in a natural way.

In January 2012, Dr. Ken Washenik participated as a presenter for the 2012 Winter Dermatology Conference in Maui. Speaking on “Emerging Therapies for Hair Loss,” Dr. Washenik discussed the treatments and new breakthroughs of molecular dermatology as well as the latest advances in Aderans’ Ji Gami product line. He stressed the advance in products still in the pipeline that are proving to be consistently stable.

If you want to receive updates on Aderans and its Stem Cell Hair Regrowth treatments, fill in the form below…

The furry mice surprise discovery led to studies on the reaction of hair follicles growth in signaling paths. The knowledge of how communication receptors interact with genes was not yet documented. One of the findings led to replicating the stem cells from healthy hair follicles in compound that included the fatty tissue found beneath the skin.

This fatty tissue carries hair stem cells, as well. Some research labs are using the tissue cells to replicate hair follicles growth studies. Sometimes referred to as “fat” stem cells, these tissue replications indicate that hair cells are a much more complex biosystem than originally thought.


Hair follicles growth has been assumed to be cyclical but the cycle mechanism was only realized during research into replication projects. Scientists expected that the cycle of growth and rest in hair growth was between 6 months and a year. The studies showed that there are millions of follicles at rest while others are in some phase of growth. The cyclical activity actually takes between 5 and 7 years.

This lengthy rest period explained why hairs were not immediately replaced when some fell out. In closer studies, it became evident that each cell within a follicle has a particular purpose for existing. In laymen’s terms, all cells are specialists. There are communicators and receptors. When the pathway between them is blocked by an overproduction of hormones, for example, the cells that are to initiate growth activity remains dormant.
The other issue that is discovered to exist in male pattern baldness, female pattern baldness and hypotrichosis simplex is the miniaturization of follicles. Scientists state that this is caused in part by the increase of the hormone, DHT. DHT is thought to create a blockage in the production of follicles by shrinking them. The other discovery by scientists is that a gene called APCDD1 has a lot to do with this miniaturization.

From that discovery, pharmaceutical projects are in process to use stem cells from this gene, from healthy sheath caps, and from tissue around the follicles in developing a stem cell solution to repair and replace hair follicles growth that has been damaged.

There are literally hundreds of identified growth factors from stem cells, and BioRegenerative Sciences describes those in its products as “natural human growth factors and other molecules” that include “TGF-b(1-3) [Transforming growth factor beta], PDGF [Platelet derived growth factor], GM-CSF [Granulocyte-macrophage colony-stimulating factor], and Interleukins (IL3, IL6-8), anti-oxidants, and other protein molecules” The company says that “by re-introducing these growth factors, antioxidants, and protein molecules through daily application” of its various products, particularly its Vital SerumTM, the result is that “damaged skin cells are repaired, and skin tissue is regenerated.” The company claims to have a unique patent-pending technology, which it calls its stem cell released molecules technology (S2RM TechnologyTM), which allows it to “capture a full and natural complement, or ‘system,’ of known molecules.”

As for Cygenx’s RegenRXx Hair Serum 90, it contains a far longer list of specific growth factors, including

• Basic Fibroblast Growth Factor(bFGF)
• Platelet-derived Growth Factor(PDGF)
• Transforming growth factor beta(TGF-beta)
• Interleukin 1-alpha (IL-1-alpha)
• Fibroblast growth factor type 5 (FGF5)
• Epidermal growth factor (EGF)
• Keratinocyte growth factor (KGF)
• Insulin-like growth factor I (IGF-I)
• Substance P
• Parathyroid hormone (PTH)
• 1,25 – dihydroxyvitamin D3

In addition, Cygenx says that its active ingredients (these growth factor molecules) are treated with what it calls its “nano-encapsulation technology” which allows the product to penetrate much deeper into the scalp than would normally be the case.

I will say this: Cygenx has a lot more scientific information on its website. Its explains the reason why this new stem cell hair growth product works this way: “[T]hese growth factors and cytokines function like a light switch, turning on lost or decreased function of the skin and scalp [and] restoring function to these aging tissues that have been previously lost or dulled by time, harsh environmental conditions and/or chemicals and genetics.”

If you’d like to comment on this product or any product, please visit our Facebook page. We’d love to hear from you.

Above is a rare video of Dutch hair restoration pioneer Dr. Coen Gho and his famous, and somewhat controversial, Hair Stem Cell Transplant technique. Dr. Gho offers his hair loss treatment through his Hair Science Institute, which operates clinics in Amsterdam, Maastricht, London and Vienna.

The Hair Stem Cell Transplant technique involves the transplantation of a new hair “substitute” created from the genetic material of existing human hair. According to Dr. Gho’s website “only a part of the follicle (a few hair stem cells, also called a ‘graft’)” are extracted from donor sites and used in the process. More traditional methods of hair transplant involve extraction of entire hair follicles.

The follicles are removed or harvested and then relocated to the balding area, where those follicles can be stimulated to produce new growth of hair. According to Dr. Gho, because his procedure uses on a portion of an existing hair follicle, and not the entire hair follicle itself, his procedure has the advantage of being able to transplant more hairs than could be accomplished when those hairs and follicles must be removed from another site on the body.


As a result, Dr. Gho is a de facto pioneer in what is sometimes called hair follicle cloning or hair multiplication. He claims to manufacture hundreds of new hair substitutes for use in a type of hair transplant operation using a single existing hair, thus eliminating the need to harvest hairs from donor sites. The availability of more hair substitutes with which to transplant may, in turn, make the hair transplant procedure itself more available to more clients.

According to an article published in 2010 in the Journal of Dermatological Treatment, Dr. Gho’s technique results in between 92.1% and 104.1% (mean 97.7%) of the partial follicular units in the donor sites” surviving and producing hair with the same characteristics. Dr. Coen and his co-author, H. A. Martino Neumann, concluded that “partial longitudinal follicular units transplanted to the recipient area can be used as complete follicular units to regenerate completely differentiated hair growth with the same characteristics as in the donor area.” The title of the article is “Donor hair follicle preservation by partial follicular unit extraction. A method to optimize hair transplantation.”

You can read the actual article by clicking Dr. Coen Gho’s Article on Hair Stem Cell Transplantation Technique

However, Dr. Gho’s treatment for hair has been criticized by some in the hair transplant community — for example, by Dr. William Rassman.

The limitations of HST, according to Dr. Gho, have to do with the number of follicles (approximately six hundred) that can be trans-located during a single procedure. With such a small number per procedure, the restoration of an entire bald scalp would take a great deal of time and expense. Having said that, the procedure’s supposed advantages include the fact that HST results in the least scarring or surgical soreness of any method available, and the assertion by Dr. Gho that nearly four fifths of the donated hairs regrow and can be reharvested for later procedures. If nothing else, Dr. Gho’s advancements offer hope in the arena of hair replacement, with the knowledge that new approaches and new technologies are being tested and tried with some success.
More traditional hair transplants are limited in scope by the limitations of donor sites; Dr. Gho’s innovative approach promises to circumvent that limitation, opening new possibilities for sufferers of male pattern baldness.

Unlike neogenesis, a process which creates entirely new hair follicles in the scalp, Dr. Gho’s procedure may have the potential to stimulate the shedding follicles to regenerate and reinvigorate the growth of natural hairs.

Hey, one favor: If you’ve enjoyed this article then please “FRIEND” us on Facebook or sign up to get our regular email updates. Onwards!

Despite the myriad delays, it appears that we are much closer to a realistic hair cloning or hair multiplication technology than many people thought! In a new study published April 18 in the journal Nature Communciations, Japanese scientists report that they successfully grew hair on bald mice by implanting specially bio-engineered adult stem cells into the dormant hair follicles on the mice.

According to Dr. Takashi Tsuji of Tokyo University of Science, the lead scientist on the project, the team was able to take extract two types of stem cells from the hair follicles of adult mice (epithelial stem cells and dermal papilla cells), cultivate the stem cells in a lab, and then transplant the cells into the scalps of hairless mice.

The result: Within three weeks, the new “bio-engineered” follicles began sprouting new hair! Not only that, but the new hair follicles continued to grow hair even when the hair was pulled out.

You can read the entire study by clicking here.

Needless to say, the research is yet another sign that a true cure for male and female pattern baldness may not be as far away as has been supposed. The scientists predict that soon hair specialist will be able to extract “tens of thousands” of stem cells from a patient, cultivated into healthy follicles and then injected back into the bald areas of a patient’s scalp.


In this study, we successfully demonstrate fully functional bioengineered hair follicle regeneration that produces follicles that can repeat the hair cycle, connect properly with surrounding skin tissues and achieve piloerection,” the Japanese scientists concluded. “This regeneration occurs through the rearrangement of various follicular stem cells and their niches. These findings significantly advance the technological development of bioengineered hair follicle regenerative therapy.”

At least two companies, Aderans Research and Replicel, are currently involved in clinical tests of similar technologies with human patients.

What appears to be novel with the Japanese technique is that it is using bio-engineered adult stems cells to “regenerate” existing but dormant hair follicles in a bald scalp. “Our bioengineered vibrissa follicle germ that was reconstituted using adult follicle-derived stem cells successfully regenerated the hair follicle following intracutaneous transplantation,” the scientists said. Other efforts have used the products of stem cells, such as cytokines and growth factors, in an effort to regenerate dormant hair follicles. But the Japansese technique appears to be a far more technical engineering of the stem cell materials themselves and then engrafting of them into the hair follicle “bulges.” “For hair follicle regeneration, the bioengineered hair germs were ectopically engrafted into the subrenal capsules of 8-week-old mice,” the scientists added.

The bottom line: As we have long insisted, research into a realistic stem cell cure for baldness is continuing worldwide. It is a slow, painful, frustrating process that is driving everyone crazy but, despite the understandable complaints of critics — who say we hear all these promises and then YEARS go by with no practical result — it appears that the research is paying off. Within the next 10 years, baldness, at least for the young, man be a thing of the past. I’m still not sure whether we will see the ultimate “Chia Pet Cure” — in which an adult man with a totally bald head sprouts hair like a Chia Pet — but even that may be possible!

Stay tuned, folks!

Well, that’s one of the claims that has been made for a stem cell approach to treating hair loss: 1,000 new hairs.

But before you run out and sign up, consider this: The average adult has approximately 100,000 to 150,000 hair follicles on his or her head and up to 5 million follicles on the entire body. (Yes, there are some variations between men and women.) But the point is this: 1,000 new hairs, while exciting, will not cover your head. It’s a start, but not enough for a cosmetically pleasing result.

We’ve recently posted on our site a very exciting research paper on stem cell treatments for hair loss. It’s the ground-breaking research that discovered that the hair follicles in bald men are not “dead” but only dormant… and that the trick to slowing down and reversing hair loss is to give these stem cells the chemicals signals they need (known as growth factors) to, in a sense, wake up. Click on the link below to read the paper…

Bald scalp in men with androgenetic alopecia
retains hair follicle stem cells but lacks
CD200-rich and CD34-positive hair follicle
progenitor cells

As for practicalities, right now there are only two ways to use this breakthrough research for yourself: (1) Sign up for a clinical trial for experimental stem cell treatments at research laboratories; or (2) try one of a tiny handful of topical stem cell growth serums that are derived from Human Fibroblast Conditioned Media (HFCM).

Growth factor serums are now being sold that take adult stem cells, usually from fat tissue, and culture them in laboratory media… allowing the stem cells to excrete what are called “growth factors.” It is these growth factors that scientists now believe are the key to reviving dormant stem cells.

However, here’s the big unanswered question: Can the use of TOPICAL growth factor serums penetrate deep enough in the scalp to revive the dormant stem cells? The manufacturers say that they do… and we have heard from delighted customers who claim it definitely has slowed down their hair loss. (We also heard from one customer, a totally bald man, who said it didn’t help him enough to make it worth while. As I said, 1,000 hairs sounds like a lot but, even if true, and I don’t know that it is, that’s not enough to cover a totally bald head.)

In the March 21 issue of Science Translational Medicine, Dr. Cotsarelis reported that his team discovered that Prostaglandin D2 is present in much higher levels in the bald areas of men’s scalp but not present in the hairier areas, such as on the side of the head. Dr. Cotsarelis’s team previously discovered that stem cells in hair follicles are not “dead,” as previously thought, but only dormant… and that something is preventing them from turning into the “progenitor cells” that actually produce hair.

In the past, medical researchers theorized that baldness is due to a genetic hypersensitivity to dihydrotestosterone (DHT). This potent sex hormone is a derivative of testosterone, made by the body with the help of an enzyme, 5-alpha-reductase. In addition to playing a major role in prostate enlargement, DHT also, in some men and women, triggers a miniaturization of the hair follicles in certain areas, causing a gradual thinning of the hair until the follicle ceases to produce any hair at all. One method of treating this is topical creams that remove excess DHT from the scalp. Another is through the prescription drug finasteride (Propecia), originally used to treat enlarged prostates. This drug is known as a 5-alpha-reductase inhibitor because it “inhibits” the action of the enzyme that produces DHT, thus reducing the amount of DHT in someone’s system… and that, in turn, can slow down and even reverse hair loss. Finasteride is effective about 50% of the time, but it comes with some risks: Recent studies warn that it may cause impotence, decreased sex drive and depression.


Now, Dr. Cotsaerlis’s team has thrown another complicating factor into the mix: Prostaglandin D2. The question they were confronting was: What causes the stem cells in hair follicles to become dormant? Is it the lack of something (growth stimuli) or the presence of something (an inhibitor)?

The team analyzed scalp tissue from men undergoing hair transplant surgeries. They discovered no fewer than 81 different genes with higher activity in the balding areas of the scalp compared to the hairier areas, and one of these genes produced Prostaglandin D2. The researchers concluded, therefore, that it was the presence of something, Prostaglandin D2, that was holding back hair growth. (To further complicate matters, however — nothing in science is ever simple — they discovered another prostaglandin, F2alpha, that appears to stimulate the growth of eyelashes.) The researchers tested their hypothesis in the lab with human hair follicles and on bald mice and, sure enough, Prostaglandin D2 definitely caused baldness when they applied it to skin.

Digging deeper, the researchers found that Prostaglandin D2 works on stem cells in combination with another protein, GPR44, which triggers a “biochemical chain reaction” when it encounters Prostaglandin D2. It might be possible, therefore, to develop a drug or cream that eliminates this other protein, GPR44, which renders Prostaglandin D harmless to stem cells in hair follicles.

Further proof that the scientists may be on the right track can be seen by the fact that Minoxidil — along with finasteride one of two drugs approved by the FDA for hair growth — activates an enzyme that produces… yes, you guessed it… prostaglandins!

So, where does all this leave us? What happened to DHT? The scientists’ best guess now is that hair growth is caused by a delicate balance of prostagladins. Prostaglandins are chemical messengers made from fatty acids, similar to hormones, present in every cell in the body. There are at least 16 different major types. It may well turn out that the old medical understanding of what causes baldness — a hypersensitivity to DHT — was correct but just too simplistic. In other words, it may be that what causes hair loss is an imbalance of prostaglandins — too much of one, not enough of another — and that all we have to do is restore that balance and voila! instance hair growth!

The creation in 1997 of a prostaglandin analog, latanoprost, and the subsequent discovery that it stimulates new hair growth in eyelashes, lends some credence to this theory.

Nevertheless, science proceeds at a snail’s pace and everyone associated with this research urges caution. As Yogi Berra put it, “it’s tough to make predictions, especially about the future.”

Dr. Cotsarelis told the BBC recently that the next step in his research is to search for compounds that have an effect on the “receptor” in the stem cells — presumably GPR44 — and then to figure out if blocking this receptor would merely prevent hair loss or could actually reverse it. However, he added that there are “several” drugs already in existence that target this “pathway” and that clinical trials are already underway.

Maddening, isn’t it? They seem to be inching closer and closer to understanding the biochemical basis for hair loss yet remain very far from having a practical, real-world treatment.

Yet we are much closer than we were even just a few years ago. You know what they say: growing old beats the alternative… a learning a little beats learning nothing.

Stay tuned!

As far back as World War II, doctors were documenting severe hair loss of men in battle and women in war zones. They suggested that hair fall out issues may be due to the materials used in ammunition that remained as particulates in the air. There is no evidence to date that this is or is not a factor.

With women nearer to the front lines than ever before, the phenomenon is being documented as an observation with them as well. In addition, women and children living in active combat areas display the same symptoms as the troops. It is now believed to be a symptom of posttraumatic stress syndrome.

Stress has been diagnosed as a cause of hair fall out disorders for several years but with so many soldiers returning home, researchers in cooperation with the U. S. Department of Defense have initiated studies to find an effective method to regrow the hair.


In developing medications for male pattern balding, researchers found that the chemical reaction in women produced negative results and side effects that were dangerous while in men the reversing of hair fall out was seen in approximately 60% of patients with minimal side effects. This was the first confirmed indication that the biological processes of hair loss while similar are not identical and that medications are not gender neutral.

Hair grafts and transplants have been the method of choice if there is sufficient remaining healthy hair to use for grafting. However, like medication that addresses male pattern balding, the success rate in women is minimal and not recommended for diffuse or widespread pattern hair loss.

The newest hair replacement method still in research and clinical trials may become the best and only permanent option for women and still an excellent choice for men. The research involving stem cell cloning methods is exhibiting spectacular progress.

The leader in the field with their clinical trial completed is the UK. Intercytex has announced successful results in a double blind study focusing on Tansgender Cloning methods. Not only is the method of reproduction of cells done using both genders but also either gender is able to receive the cells from the other without rejection issues. This major advancement for hair fall out disorders is exciting.

Besides genetic causes, there are environmental, commercial product, emotional, and physiological reasons that result in balding problems. Products such as vitamin enriched shampoos and FDA approved topical hair growth products produce better hair growth in some of these instances.

An emotional issue that has been confirmed is related to being in a war zone. Whether the loss of hair is due to stress or due to some chemical in the air has yet to be determined. A combination of changes in diet, emotional counseling and topical medication treatments generate better hair growth than one method alone.


Chemicals in such commercial products as shampoos, dyes, and hair gels are suspected of causing thinning hair and excessive shedding. The method of most success for this causation is to find the chemical that is behind your reaction and stop using any product that contains the chemical. Often, organic products are useful in restoring better hair growth.

One of the least talked about environmental cause is ringworm of the scalp. Ringworm is a fungus not a parasite. Nonetheless, the fungus feeds on the tissues where hair follicles grow and create hair loss. This is also the easiest to treat once diagnosed. The good news is that the treatment will not produce damage if the cause is not the fungus. Washing your hair with a vinegar-water solution will stop the fungus and better hair growth will ensue.

Physiological reasons unrelated to hair loss diseases such as alopecia, may see hair loss as a symptom of the underlying disease. One of the early symptoms of Lyme disease, Lupus and Thyroid disease is hair thinning and balding. These symptoms often mimic pattern baldness issues. The treatments for pattern baldness is ineffective for better hair growth because of the interaction of medications for the main disease. Low-level laser treatments may be the method of choice in such instances.

Regardless of the cause of hair shedding, thinning or loss, improving your intake of a balance of vitamins and minerals will assist in better hair growth under most circumstances.

For thousands of years, men and women who experienced balding had to live with it. Usually, they wore hats, bonnets, or headscarves to hide their hair. No one gave much thought to “follicles” or to cyclical growth. It was accepted – even when hair follicle growth was identified that losing your hair was part of aging or inherited. Empyreal evidence supports both assumptions.

Unfortunately, such evidence accepted as fact reduced inspiration to find out why these two factors seemed to be more prevalent in one family than in another. Modern scientists do not accept anything as written in stone fact. By the 1960s, the discovery of DNA molecules in the body was launching into genetic research. Part of this research involved hair follicle growth and the actual process.


What was found then has been expanded upon today. Hair follicle growth occurs in spans ranging from 5 to 7-year cycles. A single follicle may remain in remission for 7 years. When it is time to grow, a receptor is activated.

At some point, scientists discovered that some follicles shrunk and these were unable to grow hair of the same type seen on the rest of the head. Hair follicle miniaturization interrupted the receipt of messaging to the receptor. Some scientists theorized that these mini follicles were activating too early in the normal cycle. The hair that grows from these tiny follicles is similar to a baby’s peach fuzz.
In research studies of follicles, scientists were able to identify certain cells within the follicle. Cellular activity began being mapped and soon it became evident that only special cells were in charge of notifying the hair to grow. Within these cells are genes and now, it is known that only one gene within one special cell has the duty to launch hair growth of the follicles.

Science has come a long way in the last 50 years. At this time, three different genetic diseases are known to be involved with the gene interaction with hair follicle growth.

As long as your hair loss is not due to an underlying chronic disease, chances are that a method exists to make your hair grow back. Some methods regenerate hair growth on a temporary basis. Others, such as transplants, may be permanent. There are even newer methods on the horizon to give hope for permanent regrowth.

Some of the temporary hair regrowth treatments include a combination of change in diet where more protein and minerals are included in your eating regime and topical treatments such as Rogaine or other medicines. Other medical treatments that increase the growth of hair include Retin A, Prospecia, Nioxin and Aderans. Each works in a different way and each for some people. None works fore everyone even if the cause is the same. Finding the right treatment that lets your hair grow back is a matter of trial and error.


Massage therapy and low-level laser therapy have proven to work but are also temporary. Medical research studies have discovered that one of the processes of hair loss is due to the follicles sleeping past their wake up cycle. In these studies, stimulating these sleeping cells did activate them and initiate growth. These methods will let your hair grow back; this method is shown to be very successful when combined with grafting and transplants.

For permanent methods that make your hair grow back, there are surgical procedures that are effective for some people. Like other treatments, not everyone has satisfactory results from these methods. In addition, not everyone is a candidate for these methods.

Most successful candidates have small areas of hair loss instead of overall balding. For grafting techniques, there must be enough hairs on the rest of the scalp to take some without creating more bald spots. The same is true for transplants. The second important factor of success is the ability to implant the borrowed hair into areas where there is sufficient nutrients for hair regrowth. At this time, there is no test for this fatty tissue that follicles require for growth. When both factors meet correctly, it will make your hair grow back.

A bright horizon with new techniques involves cloning the stem cells from the hair follicles and from skin tissue stem cells. According to reports, these new methods of cloning make be the best methods that make your hair grow back.

Replical’s hair regeneration technology involves the harvesting and multiplication of what are called dermal sheath cup (DSC) cells located in a “bulb” at the base of the hair follicle.

In laboratory studies, RepliCel™ scientists have found that DSC cells both stimulate the development of mature hair follicles and the creation of new ones. The scientists discovered that the DSC cells are capable of actually regrowing the dermal papilla and hair follicles themselves.

The way the treatment works is this. Trained technicians harvest DSC cells at locations in the base of the neck, where they are plentiful. These harvested DSC cells are then placed in a special nutrient medium in a laboratory where they multiply.


Once there are a sufficient number of DSC cells taken from a patient’s own neck hairs, the new cells are injected directly into the scalp where hair loss has occurred. Like reseeding a lawn, the DSC cells “migrate” to hair papilla that already exist and effect an regenerative transformation. They also create brand-new hair follicles.

Most importantly, the harvested DSC cells are taken from hair follicles, at the base of the head near the neck, that are not as sensitive to male sex hormones (androgens) which, scientists believe, are what cause the hair follicle miniaturization that makes hair loss happen in the first place.

Also, because the DSC cells come from the patient’s own body, rejection of the cells is far less likely.

RepliCel™ is now accepting queries from individuals who might be interested in participating in its new round of clinical trials. If you’d like more information about possibly participating in its new Phase I/IIa clinical trial of its hair regeneration technology, fill in the form below:

A number of hair restoration surgeons are now claiming that they can effect genuine hair regeneration from dormant follicles through the combination of two medical therapies: So-called PRP (Platelet Rich Plasma) Injections and a product called ACell MatriStem. Acell MatriStem is “porcine urinary bladder matrix,” derived from pig bladder cells, that has proven to be very helpful in wound healing. And as readers of this website know, wound healing has been at the forefront of research into hair cloning and hair follicle regeneration.

At the 19th annual conference last year of the International Society of Hair Transplant Surgeons held in Anchorage, Alaska, Dr. Gary Hitzig presented evidence that Acell “attacts” adult stem cells to a “wound” and converts them into the progenitor cells that, in the case of hair follicles, actually grow hair. So, the idea is to combined Acell with large amounts of adult stem cells taken from the patient’s own body — which is where the Platelet Rich Plasma comes in — and then to inject this concoction into the bald areas of the scalp. The hope is that it will send signals to the adult stem cells lurking in the dormant hair follicles and, in essence, wake them up.


A number of clinics worldwide are now performing this procedure — apparently with some success. The pictures I’ve seen definitely show renewed hair growth but it’s not a panacea. It’s still a messy, bloody business that looks a lot like hair transplant surgery, but many people are more than willing to undergo it.

What is interesting is the proposed mechanism for how this works. In essence, the Acell and PRP combination floods the scalp area with growth factors that play a crucial role in jump-starting these comatose hair follicle stem cells.

This is a lot like what Histogen is proposing with its Hair Stimulating COmplex (HSC) and what Cygenx claims is the basis of its RegenRXx stem cell hair serum. A lot of different research strands are coming togehter, in other words, that point to growth factors as *the* key in basically curing baldness and coming up with a realistic stem cell hair growth treatment.

If this works… and it can be combined with a genuine hair cloning technology like that of RepliCel or Aderans, then we truly might see a realistic baldness cure — and sooner rather than later.

Researchers have yet to determine if a mutated gene produces the increased hormone that blocks the signal path in some cases of balding. The scientists have not concluded what the precise interaction between DHT and genes such as APCDD1 are in hair loss diseases or if there is any connection at all. What is concluded is that a single gene does create a single balding issue that is considered hereditary and that DHT blocks the signaling path that stops hair growing.

While APCDD1 is proven to miniaturize follicles and while follicle miniaturization is known to exist in three genetic hair loss diseases, the gene is confined to only one of the diseases. Follicular miniaturization does stop hair growing by replacing it with smaller, finer hairs that may be growing in an abnormal adult cycle.


This complex process of hair growth, which on the surface appeared to be quite simple is part of the reason that finding one cure for balding has been delayed. Currently, researchers are investigating the possibility that infusing replicated genetic materials will cure the majority of issues that stops hair growing. However, if DHT is caused by something other than genetic mutations, how reversing this increased hormone in the scalp remains a project to be studied in greater depth.

Could a cloned cell overpower the cells that stops hair growing? Or, will there need to be a combination of treatment procedures in order to improve success in this new technology? Scientists favor the concept of combination treatments where the cloned cells are infused with a specific medium solution that increases activity of the hair growth potential.

In a study using mice, Drs. Kevin McElwee and Rolf Hoffmann found that cells taken from the dermal sheath cup generated new follicles. The sheath cup is considered to be the reservoir of those stem cells that are responsible for follicular cyclical activity. The solution for cell replication is included in replacement treatments.

RepliCell was produced based on these findings and is currently in clinical trials around the world. Intercytex, a U.K. company, is about to release a topical product that replaces the mutated cells that stops hair growing.

The furry mice surprise discovery led to studies on the reaction of hair follicles growth in signaling paths. The knowledge of how communication receptors interact with genes was not yet documented. One of the findings led to replicating the stem cells from healthy hair follicles in compound that included the fatty tissue found beneath the skin.

This fatty tissue carries hair stem cells, as well. Some research labs are using the tissue cells to replicate hair follicles growth studies. Sometimes referred to as “fat” stem cells, these tissue replications indicate that hair cells are a much more complex biosystem than originally thought.


Hair follicles growth has been assumed to be cyclical but the cycle mechanism was only realized during research into replication projects. Scientists expected that the cycle of growth and rest in hair growth was between 6 months and a year. The studies showed that there are millions of follicles at rest while others are in some phase of growth. The cyclical activity actually takes between 5 and 7 years.

This lengthy rest period explained why hairs were not immediately replaced when some fell out. In closer studies, it became evident that each cell within a follicle has a particular purpose for existing. In laymen’s terms, all cells are specialists. There are communicators and receptors. When the pathway between them is blocked by an overproduction of hormones, for example, the cells that are to initiate growth activity remains dormant.
The other issue that is discovered to exist in male pattern baldness, female pattern baldness and hypotrichosis simplex is the miniaturization of follicles. Scientists state that this is caused in part by the increase of the hormone, DHT. DHT is thought to create a blockage in the production of follicles by shrinking them. The other discovery by scientists is that a gene called APCDD1 has a lot to do with this miniaturization.

From that discovery, pharmaceutical projects are in process to use stem cells from this gene, from healthy sheath caps, and from tissue around the follicles in developing a stem cell solution to repair and replace hair follicles growth that has been damaged.

1. Chronic vitamin deficiency is a common cause world wide for slow hair growth. This is seen in poor neighborhoods in the U.S, Canada and the U.K., as well as in third world countries where there is difficulty balancing the nutritional needs. The condition may be the first of several signals that other medical issues are on the horizon. Rickets, Chronic Anemia and Diabetes are some examples.

2. High levels of stress is a confirmed cause of slow hair growth. Stress comes in a variety of formats. Some types of stress related to slow growth include workaholics and high achievers. People who strive for perfection are prone to this condition, as well. Additionally, recent studies indicate that people who live in demanding, controlling or abusive situations display retarded hair growth. Usually, if this is severe, emotional or mental counseling is effective to reverse the symptoms.


3. Hypothyroidism is typically found as an underlying cause of slow hair growth in children. Other symptoms include retarded physical growth that is well below the norm expected for the age of the child; and, slowing of understanding common words and concepts for the age. Sometimes, this can be a symptom of mental retardation. The only way to know if your child does have this problem is to see your pediatrician; and, ask if this is a possibility.

4. Alopecia is the most common known factor for slow hair growth. This disease is seen in both men and women and has many forms to it. Women, more than men, notice that their hair is growing more slowly than it used to. Men notice it when thinning spots appear on the crown of the head or fuzzy hairs take the place of strong thicker hair. So far, researchers have concluded that the cause is related to a gene that is unable to communicate with other genes that direct the cycle of hair growth.

5. Genetic or hereditary baldness in men and women presents with slow hair growth because of an increase in a hormone that inhibits the messaging of hair receptors. This hormone is called DHT.

In both of the last two causes, medications on the market and in pipeline research are quite effective for stopping and reversing the effects of slow hair growth.

Technically, HSC is a simulated cellular material grown in a combination of Inhibin, Activin and Follistatin. These molecular genetic participants are developed in a stem cell simulator to generate new generations of the molecular parent cell.

For the purpose of clarity, stem cells are found in every part of the body. They are not limited to human or animal fetuses. Hair and skin cells have stem cells all their own. The scientific definition of “stem cell” describes an undifferentiated cell [any cell] of a multicellular organism [any life form over the single cell amoebic stage] capable of replicating itself.

Hair follicle stem cells are able to replicate themselves when placed in a conducive environment. The process of generating hair follicle stem cells involves the creation of niches. You could think of niches as incubators where the appropriate growth material allows the cell to duplicate as if in an embryonic condition.


It was in the late 1990s that researchers discovered that Wnt [also known as Follistatin] was the binding protein agent between all three. This discovery opened up new methods and techniques for a multitude of possibilities. In 2002, one of those studies resulted in a study of skin cell regeneration in mice with scarring. Not only did the severely damaged skin regenerate, so did the hair in the damaged skin area.

By 2004, reports in Science Daily reported on the discovery of hair growth cells at the base of the follicles that when properly stimulated or replicated had the potential to eradicate baldness in men and women.

Once the cyclical process was understood at the molecular level, scientists realized that abnormal follicles were at the root of the normal growth patterns. Each follicle has many types of cells and part of the process requiring the University of Penn researchers to first identify which cell did what.

That accomplished, they were able to test the theory of hair regeneration. To their amazement, it not only worked, but worked faster than anticipated. At the same time, other researchers were experimenting with tissues called fibroblasts.

Still, it was not until 2011 that molecular science understood the nature of dormant cells or the reason that these cells were not responding to natural growth. They discovered that in the fatty layer of skin, there are cells whose sole job is to communicate with the follicles and tell these dormant growth cells to get going and grow. These communicators were part of the problem. From this, the knowledge that stem cells need an outside source to wake them, some researchers began working toward stimulation techniques meant to wake the sleepers.

In the simplest of terms, Inhibin and Activin are protein compounds that need a third party protein attached to them in order to become activated. Both inhibin and activin have been studied since the 1930s and were known to be important proteins in the growth process. Unfortunately, scientists did not know what type of growth or what active their ability.

The most necessary stimulant agent became known as Follistatin. Three elements are required to shake up these dormant cells: Inhibin, Activin and Follistatin. This combination became nicknamed HSC. Follistatin was the one element that was necessary to bind the other two together to create the communication between cells.

Since then scientists have been testing and developing products utilizing this basic premise. By substituting simulated cell development, the company focused on the ability to provide a product that is able to be used by more than one person. In traditional stem cell hair regeneration, the treatment involves implanting the cells into the scalp. However, this can only be done using the cells of one source for one person.

Histogen was one of the products developed for use by a large group of people without the need for transplanting cells or hair follicles. The advantage is two-fold. Because it does not use actual human or animal cells, cross contamination and rejection issues are eliminated. Since the product can be distributed on a wide scale, it reduced the cost of services and time constraints of those people at the clinics trained to use it.

The product is a liquid that is injected in tiny amounts into the fatty layer just below the skin. Histogen essentially takes the position of the communicators and wakes up the sleeper cells that cause hair to grow. While it may not be a one-time process, it is not a lengthy as a hair transplant. Implantation of stem cells is still years away, at best.

Founded in 2006, Follica is a subsidiary of Pure Tech Ventures in Boston, Ma. Pure Tech Ventures is an investment firm identifying scientific breakthroughs and supporting the research in order to develop new biotech methodologies for medical applications.

Dr. Chuong’s research originally focused on ways to help heal severe wounds from battle to burns. In his lab, he had experimented with several techniques designed to heal deep wounds that went below the epidermis and were splayed open. After years of almost successes, he used a technique discovered by other researchers that showed regeneration of hair follicles. He had no particular reason to believe that such methodology would be successful in his study but expected that he would be able to eliminate one more route.

As is true in nearly all cases, scientists do not operate in a vacuum and attempt new concepts without some stimulus from another research preceding it. In this case, Dr. George Cotsarelis used Dr. Chuong’s information and redirected his own interests. Dr. Cotsarelis discovered that traumatic disruption of the skin under certain circumstances is able to regenerate spontaneously.

In the 50s and 60s, there were sporadic reports of this self-regeneration connected with wound healing during the Korean War and after. With the lack of knowledge on the part of the scientific community about molecular biological structures, about the genetic composition of all life, and the existence of stem cells, the incident reports were shelved.


In the interim, science has caught up with the nature of biological structuring. With nanotechnology on the rise, many new identifiers are being shared across the scientific world. Dr. Cotsarelis was able to demonstrate manipulative techniques that worked consistently to regenerate hair growth in damaged skin.

By manipulating the key signaling pathways that communicate follicle formation, Dr. Cotsarelis and Dr. Chuong were able to prove what until then had been no more than a theory. There are several pathways and several methods of manipulation that have been discovered. Some companies are using drug compounds in order to wake up sleeping stem cells within the fatty layer of tissue beneath the skin. Follica is taking a different approach. Instead of regeneration, Follica is researching multiple schemes of neogenesis – regenerating hair and skin cells where none exists.

Rather than waking dormant cells that are present, Follica is studying methods of developing new cells that had previously been destroyed. One of the newest patents that Follica has applied for includes Lithium treatments there have been research studies over the last 25 – 30 years that reveal a specific form of lithium when used in treatments for skin regeneration have shown a modicum of success. Whether this is what Follica is doing with their patent is not able to be confirmed.

Rather than referring to Follica as hair regeneration, it should be called by the term Dr. Chuong applied to it 2009 – hair engineering. This method focuses on morphogenesis – the study of how cells are assembled into functional forms. It is through this basic understanding of cell formation and assignment of what those cells are designed to do leads to a more complete understanding of how skin cells and hair follicles are able to regenerate on their own.

One of the most important discoveries by Dr. Chuong was that by tuning the balanced activity of a molecular pathway, it becomes possible to alter the shape, size and number of the ectodermal organs … skin cells.

Another exciting development in the research resulting from studies in hair loss regeneration involves the understanding of the cells in the fat layer of the skin. This research was reported by Yale University in the fall of 2011. What these researchers discovered was that without fat cells hair will not grow. Prior to this study, little credit was given to fat cells beyond the need to regulate body heat systems. The study has yet to go as far as to confirm that this could be the key to a cure for baldness but hopes in medical endocrinology are high that it will lead to a cure. This Yale Study did emphasize that this is not related to genetic causes for hair loss to their knowledge. It may lead to an understanding in how wounds heal or tumors grow.

Helping people through researching the many ways in which cells interrelate is the current focus of Follica’s mission. In the future, Follica is planning on production of several trademarked products, which are currently undergoing human testing in Asia. A surprising result of this cellular research being done worldwide includes the discovery that loss of hair in the ear, possibly related to some forms of baldness, is connected to hearing loss. Growing hair stem cells in cochlea material could lead to hair regeneration and reversal of baldness.

Researchers have yet to determine if a mutated gene produces the increased hormone that blocks the signal path in some cases of balding. The scientists have not concluded what the precise interaction between DHT and genes such as APCDD1 are in hair loss diseases or if there is any connection at all. What is concluded is that a single gene does create a single balding issue that is considered hereditary and that DHT blocks the signaling path that stops hair growing.

While APCDD1 is proven to miniaturize follicles and while follicle miniaturization is known to exist in three genetic hair loss diseases, the gene is confined to only one of the diseases. Follicular miniaturization does stop hair growing by replacing it with smaller, finer hairs that may be growing in an abnormal adult cycle.


This complex process of hair growth, which on the surface appeared to be quite simple is part of the reason that finding one cure for balding has been delayed. Currently, researchers are investigating the possibility that infusing replicated genetic materials will cure the majority of issues that stops hair growing. However, if DHT is caused by something other than genetic mutations, how reversing this increased hormone in the scalp remains a project to be studied in greater depth.

Could a cloned cell overpower the cells that stops hair growing? Or, will there need to be a combination of treatment procedures in order to improve success in this new technology? Scientists favor the concept of combination treatments where the cloned cells are infused with a specific medium solution that increases activity of the hair growth potential.

In a study using mice, Drs. Kevin McElwee and Rolf Hoffmann found that cells taken from the dermal sheath cup generated new follicles. The sheath cup is considered to be the reservoir of those stem cells that are responsible for follicular cyclical activity. The solution for cell replication is included in replacement treatments.

RepliCell was produced based on these findings and is currently in clinical trials around the world. Intercytex, a U.K. company, is about to release a topical product that replaces the mutated cells that stops hair growing.

Hair cloning is generally considered to be any technique that attempts to harvest hair follicle cells from a patient, multiply them in growth media in a lab, and then use the new cells to “reseed” bald scalps. Dr. Barusco added that hair cloning will make possible transplants for people who couldn’t have them in the past because they lacked a sufficient amount of donor hair. At least four companies are now actively engaged in hair cloning research – RepliCel Life Sciences, Aderans Research, Follica and Dr. Coen Gho’s Hair Science Institute. They differ slightly on which type of cells they harvest and use in their process.


In 2008, hair cloning was in the news because of pioneering trials being conducted by a British company, Intercytex, that subsequently had financial difficulties and was sold. The hair challenged public became discouraged by the frequent delays so that many today believe that hair cloning is all hype and that the technology will never arrive.

However, Dr. Barusco doesn’t feel that way. He is encouraged by the research done so far and by the fact that companies such as Aderans and RepliCel are moving on to Phase II clinical trials of hair cloning with greater numbers of subjects.

Hair cloning is not the same thing as stem cell treatments. Other companies, such as Histogen in San Diego, are attempting to develop products that restore and reactivate existing hair follicles on balding heads that have been, in a sense, shut off. The hope is that a unique combination of special growth factors and cytokines will be able to “wake up” these dormant hair follicles so that they once again produce hair on a regular basis. Histogen’s Hair Stimulating Complex, which is currently in development, will be an injectable treatment performed in a medical clinic under a doctor’s supervision.

Cygenx currently produces a growth factor hair growth serum, which it calls RegenRXx, that is available now as a topical lotion. It is applied either alone or with the aid of a dermaroller.

In 2003, Dr. McElwee and Hoffman at Phillips University in Marburg, Germany discovered dermal sheath cup cells had the ability to initiate mature hair follicles cell growth. Dermal sheath cup cells or DSC cells are the portion of the hair bulb located at the lower pole that appears to surround the bulb in a distinct cup like shape. These particular cells are capable of formation of new hair when grown in a proper medium. In their experiments, the researchers used Green fluorescent protein as the growth medium.

Part of their research discovered a method of identifying mesenchyme cells by use of these DSC cells. Mesenchyme is the embryonic tissue derived from the derma level and differentiates connective tissues. These MSCs are multipotent cells from tissues such as adipose tissue, adult muscle or dental pulp from baby teeth. These cells display a direct correlation to the cyclical process of hair cell growth. This was a tremendous breakthrough that coupled with other researchers findings became one of the baselines for medical research into hair regeneration.

This discovery led to applications worldwide for patents to produce a variety of products and to continue research in hair growth procedures. RepliCel has patented the process for claiming the DSCs and preparing them for replication. Once these cells have replicated in the thousands, they are injected into the necessary areas of the patient’s scalp.


There are several types of alopecia related causes of balding in men and women. This method of treatment is believed to be on track to treat many of these. The most common alopecia is androgenetic alopecia or pattern baldness. This is seen in men and women and is a genetic predisposition disorder. In some cases, it is believed that the follicle shrinks, which disallows the natural replication of hair in adjacent cells.

Yet, with the wars in Iraq and Afghanistan and the civil outbreaks across the Middle East, the research for trauma induced alopecia. This is caused by burns, chemical trauma, scarring from skin cancer surgery and other surgical procedures. While RepliCel is thought of more in the field of hair regeneration, the research and product development applies to far more.

Traction alopecia is another common form of hair loss. Seen in men, women and children, this is caused by pulling on the hair. Some people do this when under stress and others when sleeping. The RepliCel procedures are working to regenerate hair in severe cases of this disorder.

Once the replicated cells are injected into the subject’s scalp area, researchers anticipate that they will produce follicles that match the patients’ cells. At that point, these follicles will initiate natural hair growth that is identical to the hair of the subject. There is early evidence that this particular process results in the hair-producing cells migrating into follicles that are adjacent to the new ones. What has also been revealed is that this migration only seeks out follicles that are in need of some kind of repair.

There is evidence that one of the causes for shrinking follicles is related to lack of or an overabundance of testosterone hormone indicators called androgens. Research has already shown that the injected replicated cells are not affected by the androgen process. This means that the new hair will not undergo shrinkage again. There is every hope that this methodology will become a permanent solution for this disease.

One of RepliCel’s proudest achievements is the current testing on human volunteers at the Scientific Research Institute for Skin and Venereal Disease in Tblisi, Ga. These clinical trials are focusing on the specific regenerative effects of DSC cell treatments in humans. In these trials the effort is for the purpose of replacing skin tissue by growing new skin from a patients own cellular structure. Additionally, the replication of hair growth in those with androgenetic alopecia is underway in the same study.

The primary purpose of these studies is to ascertain the safety of these injections in human bodies and if there are unexpected consequences or rejection issues as yet undiscovered. All of the volunteers at the Tblisi clinic undergo biopsies in order to properly document any issues before, after or during the process. RepliCel is not a drug treatment therapy. Yet, for the purpose of documentation RepliCel is following procedures outlined for pharmaceutical research studies. It is estimated that this formula for its research will allow the necessary FDA approval to be expedited when the research is completed.

Technically, HSC is a liquid that is made up of stem cell products, Inhibin, Activin and Follistatin, that are then injected into the scalp of balding men and women to stimulate new hair growth. Recent research has revealed that people who suffer from genetic pattern hair loss do not have fewer stem cells or hair follicles than normal people. What is appears to be different in bald people is that, in a sense, the growth of existing stem cells is stunted in some way. The stem cells are not able to develop into what are called “progenitor” cells which are the cells that actually produce hair on an ongoing basis. In the past few years, therefore, the question that has nagged scientists is this: What will stimulate these stem cells into further growth?

Histogen’s Hair Stimulating Complex is one answer to this question. Researchers at Histogen and other companies have focused on a special class of proteins known as growth factors that appear to “jump start” stem cell development in hair follicles. There are hundreds of growth factors, however, and the question is now: which growth factors and in what combination?


The development of Histogen’s Hair Stimulating Complex was delayed for years by a patent infringement lawsuit; however, in late 2011 a federal judge dismissed the lawsuit and concluded that Histogen’s product does not infringe on existing patents.

Cygenx’s RegenRXx product is also made up of growth factors and cytokines derived from Human Fibroblast Conditioned Media, and it is meant to be applied topically, on the scalp. To aid penetration of the product into the hair follicles, Cygenx also sells and recommends use of a dermaroller.

Histogen, however, plans on marketing its Hair Stimulating Complex as an injectible — which means that it will only be available in a clinical setting, such as a doctor’s office or medical hair treatment facility. It is not clear when this product will be available but it will no doubt be a few years at least. Histogen has enrolled patents in its Phase I/II clinical trial in the Philippines.

For the purpose of clarity, stem cells are found in every part of the body. They are not limited to human or animal fetuses. Hair and skin cells have stem cells all their own. The scientific definition of “stem cell” describes an undifferentiated cell [any cell] of a multicellular organism [any life form over the single cell amoebic stage] capable of replicating itself.

Hair follicle stem cells are able to replicate themselves when placed in a conducive environment. The process of generating hair follicle stem cells involves the creation of niches. You could think of niches as incubators where the appropriate growth material allows the cell to duplicate as if in an embryonic condition.

It was in the late 1990s that researchers discovered that Wnt [also known as Follistatin] was the binding protein agent between all three. This discovery opened up new methods and techniques for a multitude of possibilities. In 2002, one of those studies resulted in a study of skin cell regeneration in mice with scarring. Not only did the severely damaged skin regenerate, so did the hair in the damaged skin area.

It was not until 2011 that molecular science understood the nature of dormant cells or the reason that these cells were not responding to natural growth. They discovered that in the fatty layer of skin, there are cells whose sole job is to communicate with hair follicles and tell the dormant growth cells within them to get going and grow. In a sense, baldness is all a failure to communicate — or rather, a failure of special communicator cells to tell stem cells to grow up. From this the knowledge that stem cells need an outside source to wake them up, researchers began working toward stimulation techniques meant to wake the sleepers.

In the simplest of terms, Inhibin and Activin are protein compounds that need a third party protein attached to them in order to become activated. Both inhibin and activin have been studied since the 1930s and were known to be important proteins in the growth process. Unfortunately, scientists did not know what type of growth or what active their ability.

The most necessary stimulant agent became known as Follistatin. Three elements are required to shake up these dormant cells: Inhibin, Activin and Follistatin. This combination is the basis of HSC. Follistatin was the one element that was necessary to bind the other two together to create the communication between cells.

Since then, scientists have been testing and developing products utilizing this basic premise. By substituting simulated cell development, the company focused on the ability to provide a product that is able to be used by more than one person. In traditional stem cell hair regeneration, the treatment involves implanting the cells taken from the patient’s own scalp (autologus). This is both time consuming, somewhat technical… and expensive.

Histogen is attempting to develop products designed for use by a large group of people without the need for transplanting cells or hair follicles. The advantage is two-fold. Because it does not use actual human or animal cells, cross contamination and rejection issues are eliminated. Since the product can be distributed on a wide scale, it reduces the cost of services and time constraints of those people at the clinics trained to use it.

The details of Recoverup’s treatment protocol are fairly clear. It involves a two-step procedure. First, the patient’s stem cells are extracted from a patient’s own adipose tissue (fat) with a liposuction-like procedure and using a local anesthetic. Approxinmately 200 ml of fat cells are removed. After that, the stem cells are then separated out using a centrifuge and alleged cultured in media until a certain concentration is met — although the “treatment” is minimal and is performed in a single day. The second phase of the treatment involves the “application” of the isolated stem cells to the scalp. The stem cells are injected into the scalp using a micro needle. The removal of the fat cells and the re-application can be done in a single day, the company says.

The cost is between USD $8,000 and $13,000.

Recoverup claims that patients see results in just two weeks. It adds that 40% of treatment areas will see either darker, thicker or faster growing hair or more hair per follicle.

We asked one of our regular writers, D.A. Leatherman, to comment on this treatment. Full disclosure: Dr. Leatherman is the CEO of Cygenx which markets a stem cell-based topical hair serum based on growth factors. We receive commissions on sales of Dr. Leatherman’s products.


“I had this exact procedure performed on my scalp three years ago with no visible improvement in hair growth. I had injected into my scalp adult autologous adipose derived stem cells with other regenerative cells (referred to as stem cell soup) that were collected from my own stem cell pellet known as the stromal vascular fraction (SVF). No hair developed, not even vellus hair.

“Although I do not know the cost of this treatment, it is a medical procedure and therefore undoubtedly expensive. Furthermore, it has no real science to lend support for any need of adding stem cells via injection into the scalp.

“The reason why I am skeptical of this treatment is because we now know that lack of stem cells is NOT the reason why people lose their hair. The University of Pennsylvania has published documented scientific data that a balding persons scalp has adequate stem cells in the scalp. So one must question, why implant more stem cells derived from your own fat?

“It is not stem cells, but progenitor cells, that are deficient in the balding scalp.

“The University of Pennsylvania did identify that what was needed to actually grow hair was to ‘wake up’ the dormant stem cells. So even if stem cells are injected subcutaneously under the scalp, how do you ‘wake up’ these stem cells? They will still need to differentiate into the hair ‘organ’ of a hair follicle, that includes, glands (both sweat and oil), muscle, nerve, hair bulb, hair shaft, and several different types of skin tissues.

“Remember, this procedure calls for the injection of stem cells, not the implantation of actual hair follicles. The growth of hair requires the actual transitioning growth from the stem cell into the entire hair organ not just a simple single cell tissue type. Regenerative medicine may have added value in the future when we can grow actual hair follicles from our own scalp in vitro (no DNA rejection) and can successf ully transplant those in vitro grown follicles into our scalp. To date, this ability alludes regenerative researchers.

“Now, let us pose the most important and essential question to shed light on identifying a real remedy for hair loss: How can we wake up the stem cells that are already in the balding scalp? Answer: growth factors, cytokines and interleukins. These signaling and communicating molecules are the normal constituents found within the body that direct the differentiation of cells and signal their associated stem cells to transform into progenitor cells with the needed receptors to form muscle, glands, hair bulbs, hair follicles and eventually hair shafts. Does this sound like a fast process? I assure you, it is not. However, science and positive outcomes are validating every day that this is the answer to correcting hair loss conditions. The sooner the candidate identifies a hair loss condition and commences use of these growth factors, the better and faster the results. The longer the condition has been present the longer it takes to reverse it.”

If you would like more information about Cygenx or wish to contact Dr. Leatherman, click here.

Well, that’s a doozy of a question, so let me try to answer it as best I can.

It’s true, the dominant theory for what causes male and female pattern baldness is a genetic hypersensitivity (like an allergy) to dihydrotestosterone (DHT), a derivative from the male sex hormone testosterone.

Make no mistake: DHT is potent stuff. It causes hair follicles to shrivel up and stop producing new hair. It’s also the hormone that causes benign prostatic hyperplasia, or BPH, also known as an enlarged prostate.

Your body converts testosterone into DHT by means of an enzyme, 5-Alpha-reductase, which comes in two forms.

So, we have three elements in this equation: the male sex hormone testosterone… the enzyme 5-Alpha-reductase… and the product of the two of them, dihydrotestosterone (DHT).


You could try to reduce the amount of DHT by reducing the amount of testosterone in your body, but that has all sorts of negative consequences, such as impotence. You can try to reduce the amount of DHT on your scalp by means of anti-DHT lotions. Or, finally, you can try to block the action of the enzyme 5-Alpha-reductase.

This latter approach is known as 5-Alpha-reductase inhibitors… and these potent drugs, available by prescription only, were first used as a treatment for BHP until patients and doctors noticed the unexpected side effect of reduced hair loss.

So far, so good. But about a year ago, cutting-edge stem cell research threw a monkey wrench into the scientific consensus. Dr. George Cotsarelis at the University of Pennsylvania Medical School discovered that hair follicles in the scalps of bald men are not “dead,” as previously thought, but actually merely dormant. More precisely, Dr. Cotsarelis discovered that the hair follicles of bald men contain as many immature stem cells as healthy hair follicles but these stem cells don’t produce as many mature progenitor cells, also known as “workhorse cells,” that actually produce hair.

The key research question right now is: How do you re-active these dormant stem cells and get them to turn into the progenitor cells that grow hair? That’s the million dollar question (literally). At the moment, it looks like the answer involves chemical signals known as growth factors and cytokines – the key ingredients in products like RegenRXx and Histogen’s upcoming Hair Stimulating Complex – but which growth factors, in which combination, and delivered how?

But before answering that question, there is another one: What is the role DHT plays in this process?

And right now, the best guess seems to be that it is DHT that keeps hair follicle stem cells from growing up and becoming progenitor cells that grow hair. In other words, it’s not so much the hair follicle itself that has a genetic hypersensitivity to DHT but the stem cells in the hair follicles.

So, what are the practical implications of this research?

FIRST, 5-Alpha-reductase inhibitors are still effective although increasingly it looks like the side effects may be worse than we thought.

SECOND, protecting hair follicle stem cells from the baleful effects of DHT may not be as difficult as we thought.

In the fall 2011, scientists at Yale University discovered chemical signals from fat cells can stimulate hair follicle stem cells to “grow up” and become the much-wanted progenitor cells that grow hair.

In an article in the scientific journal Cell, the Yale researchers reported that, at least in mice, a special kind of stem cell found in fat – known as adipose precursor cells – was necessary for hair follicles to produce hair. More specifically, fat stem cells produce chemicals known as platelet-derived growth factors (PDGF), and it is these growth factors that may be the missing “on switch” that tell stem cells in hair follicles to turn into mature progenitor cells that grow hair. That’s one of the reasons why we’re so excited about Cygenx.

In other words: We’re pretty darn close to figure out the chemical mechanism that causes male and female pattern baldness. This is huge!

That’s why, despite all the cynicism you hear on the various hair loss forums – in which many denounce all research and leads as “scams” and con games – the research into stems cell hair treatments is truly moving forward. The problem is that science moves at a snail’s pace… and we’re all understandably impatient.

So, to summarize: It looks increasingly like DHT somehow acts like pixie dust on Peter Pan and keeps hair follicle stem cells from growing up and becoming the progenitor cells that produce hair. The result is that the follicles shrink, the hair gets thinner and thinner and eventually stops growing altogether.

If we can figure out how to counteract that process, and send the hair follicle stem cells the chemical signals they need to restart their engines, so to speak, we may at last have a realistic treatment for hair loss in our lifetimes.

If you have any questions about any of this, feel free to contact me.

ARI is in the second phase of developing cellular restoration products for hair regrowth applications. In November 2011, Aderans announced that it was opening new facilities for additional clinical trials in association with Radiant Research in four new cities across the nation. Some clinics are still accepting people who wish to participate in the study. To date, over 356 individuals have been joined the study as clinical subjects.

Aderans Research’s signature treatment involves using a subject’s own hair stem cells, thus eliminating concerns about rejection. By cultivating stem cells from the subject himself or herself, other complications – such as infections or disease transmission — are dramatically reduced. ARI studies regeneration of hair cells at the follicular level for both men and women.

A stem cell is any cell from any part of the body – skin, brain, fatty tissue, hair, or organs – which has the ability to replicate itself. This process is much like the stem of a plant which sprouts leaves along its length. These cells are one part of the ingredient in hair regeneration. The second part is the cell that acts an “alarm clock” for waking dormant cells.

It has been known since the University of Pennsylvania’s study in 2004 that hair follicles include multiple cells. Some of these cells are hair replication cells, which control the cyclical growth of hair. Other cells are communicator cells, which are necessary to wake the dormant cells when it is time for them to grow. People with certain types of hair loss are now known to lack the alarm clock cells (also known as progenitor cells). Unless there is a method to inform the dormant cells that it is time to activate, hairs are not generated.


In a Yale University research program in November 2011, it was discovered that the communication cells, which instruct the hair cells to grow, are found in the fatty layer below the epidermis. The full ramifications of this discovery are still not clear but hopes remain strong that this will lead to the ability to replicate other cells in the human body. Until this time, the value of the fatty layer was not understood.

With the latest breakthroughs in molecular endocrinology regarding communicator cells in the fatty layer beneath the skin and with the Yale research demonstrating the importance of fat cells for hair growth, Aderans has developed products that taking advantage of these new breakthorughs. However, this does not address issues with an underlying cause related to the contraction of hair follicles.

One of the major problems that hair restoration doctors face is the patchy effect of surgical transplants. The question of why one area of the scalp would allow hair regrowth while another in close proximity would not could not be explained. The Yale and University of Penn studies shed light on this problem. With that, researchers around the world have been working to develop methods to overcome the problem.

During Phase I of Aderans’s clinical studies, conducted in the U.K., Aderans focused on pattern redistribution issues noted in traditional surgical transplants and medical treatments for regrowth. One of the problems documented was the limitation of distribution of hair regrowth in surgical transplants.

The process used by Aderans involves the reproduction or replication of hair cells taken from a subject. By removing hair samples from the subjects scalp, the stem cells from the follicle are stripped out and placed in a medium that incubates the cells. The medium contains nutrients that are necessary for the cells to replicate on their own. In this way, there are an unlimited number of hair follicles to replant in the subjects scalp. In addition, the fat cells that are a necessary part of the continuation of hair growth develop simultaneously during replication due to the medium used.

Part of the medium used by Aderans is a small amount of tissue removed from the nape of the subject’s neck. By using this method, the fat cells become an integral part of the cloning process and compatible with the subject. This tissue — used with Wnt proteins — stimulates the replication system of the cells in a natural way.

In January 2012, Dr. Ken Washenik participated as a presenter for the 2012 Winter Dermatology Conference in Maui. Speaking on “Emerging Therapies for Hair Loss,” Dr. Washenik discussed the treatments and new breakthroughs of molecular dermatology as well as the latest advances in Aderans’ Ji Gami product line. He stressed the advance in products still in the pipeline that are proving to be consistently stable.

Founded in 2006, Follica is a subsidiary of Pure Tech Ventures in Boston, Ma. Pure Tech Ventures is an investment firm identifying scientific breakthroughs and supporting the research in order to develop new biotech methodologies for medical applications.

Dr. Chuong’s research originally focused on ways to help heal severe wounds from battle to burns. In his lab, he had experimented with several techniques designed to heal deep wounds that went below the epidermis and were splayed open. After years of almost successes, he used a technique discovered by other researchers that showed regeneration of hair follicles. He had no particular reason to believe that such methodology would be successful in his study but expected that he would be able to eliminate one more route.

As is true in nearly all cases, scientists do not operate in a vacuum and attempt new concepts without some stimulus from another research preceding it. In this case, Dr. George Cotsarelis used Dr. Chuong’s information and redirected his own interests. Dr. Cotsarelis discovered that traumatic disruption of the skin under certain circumstances is able to regenerate spontaneously.
In the 50s and 60s, there were sporadic reports of this self-regeneration connected with wound healing during the Korean War and after. With the lack of knowledge on the part of the scientific community about molecular biological structures, about the genetic composition of all life, and the existence of stem cells, the incident reports were shelved.

In the interim, science has caught up with the nature of biological structuring. With nanotechnology on the rise, many new identifiers are being shared across the scientific world. Dr. George Cotsarelis was able to demonstrate manipulative techniques that worked consistently to regenerate hair growth in damaged skin.


By manipulating the key signaling pathways that communicate follicle formation, Dr. Cotsarelis and Dr. Chuong were able to prove what until then had been no more than a theory. There are several pathways and several methods of manipulation that have been discovered. Some companies are using drug compounds in order to wake up sleeping stem cells within the fatty layer of tissue beneath the skin. Follica is taking a different approach. Instead of regeneration, Follica is researching multiple schemes of neogenesis – regenerating hair and skin cells where none exists.

Rather than waking dormant cells that are present, Follica is studying methods of developing new cells that had previously been destroyed. One of the newest patents that Follica has applied for includes Lithium treatments there have been research studies over the last 25 – 30 years that reveal a specific form of lithium when used in treatments for skin regeneration have shown a modicum of success. Whether this is what Follica is doing with their patent is not able to be confirmed.

Rather than referring to Follica as hair regeneration, it should be called by the term Dr. Chuong applied to it 2009 – hair engineering. This method focuses on morphogenesis – the study of how cells are assembled into functional forms. It is through this basic understanding of cell formation and assignment of what those cells are designed to do leads to a more complete understanding of how skin cells and hair follicles are able to regenerate on their own.

One of the most important discoveries by Dr. Chuong was that by tuning the balanced activity of a molecular pathway, it becomes possible to alter the shape, size and number of the ectodermal organs … skin cells.

Another exciting development in the research resulting from studies in hair loss regeneration involves the understanding of the cells in the fat layer of the skin. This research was reported by Yale University in the fall of 2011. What these researchers discovered was that without fat cells hair will not grow. Prior to this study, little credit was given to fat cells beyond the need to regulate body heat systems. The study has yet to go as far as to confirm that this could be the key to a cure for baldness but hopes in medical endocrinology are high that it will lead to a cure. This Yale Study did emphasize that this is not related to genetic causes for hair loss to their knowledge. It may lead to an understanding in how wounds heal or tumors grow.

Helping people through researching the many ways in which cells interrelate is the current focus of Follica’s mission. In the future, Follica is planning on production of several trademarked products, which are currently undergoing human testing in Asia. A surprising result of this cellular research being done worldwide includes the discovery that loss of hair in the ear, possibly related to some forms of baldness, is connected to hearing loss. Growing hair stem cells in cochlea material could lead to hair regeneration and reversal of baldness.

As a result, Dr. Gho claims to manufacture hundreds of new hair substitutes for use in a type of hair transplant operation using a single existing hair, thus eliminating the need to harvest hairs from donor sites. The availability of more hair substitutes with which to transplant may, in turn, make the hair transplant procedure itself more available to more clients. Many men facing male pattern baldness are waiting anxiously for the release of the approved new process, although some hitches in technical research have delayed the release and availability of this newest procedure.


Dr. Gho’s treatment for hair has been criticized by some in the hair transplant community — for example, by Dr. William Rassman.

Thus Dr. Gho’s currently available procedure, referred to as Hair Stem cell Transplant, or HST, combines elements of hair transplant and hair multiplication. The limitations of HST, according to Dr. Gho, have to do with the number of follicles (approximately six hundred) that can be trans-located during a single procedure. With such a small number per procedure, the restoration of an entire bald scalp would take a great deal of time and expense. Having said that, the procedure’s supposed advantages include the fact that HST results in the least scarring or surgical soreness of any method available, and the assertion by Dr. Gho that nearly four fifths of the donated hairs regrow and can be reharvested for later procedures. If nothing else, Dr. Gho’s advancements offer hope in the arena of hair replacement, with the knowledge that new approaches and new technologies are being tested and tried with some success.

More traditional hair transplants are limited in scope by the limitations of donor sites; Dr. Gho’s innovative approach promises to circumvent that limitation, opening new possibilities for sufferers of male pattern baldness.

Unlike neogenesis, a process which creates entirely new hair follicles in the scalp, Dr. Gho’s procedure may have the potential to stimulate the shedding follicles to regenerate and reinvigorate the growth of natural hairs.

Thankfully, you do not have to just suffer through it. There are many products out there that can help reduce the effects of slow hair growth, and actually make your hair grow faster. With most of these products, you will see the best results when you catch it early on. However, results can be had even if you have been experiencing slow hair growth for some time. It may just take longer to see results in those cases. Be patient, and you will see results once you find the right treatment for you. Not every treatment works for everyone, but the following list of treatment products should get you started in the right direction.

One of the treatment options you have available to you is the natural herbal treatments. There are many of these out there. InHairIt is one of these products. It can be found at InHairIt.com. Another of these products is Hair Formula 37. Verseo.com also offers an herbal shampoo and conditioner that claims to increase hair growth by 123 percent within twenty eight days. Most of these herbal products have similar ingredients, such as saw palmetto. These products have been shown to help some people with slow hair growth.

Whorush: 4 sites by this AdSense ID

Whorush: 4 sites by this AdSense ID

Whorush: 4 sites by this AdSense ID

Whorush: 4 sites by this AdSense ID

There are also chemical and medical treatments that can help you combat slow hair growth. The Bosley system consists of medical treatments that stimulate the hair follicles and increase hair growth. You can learn more about Bosley and get information about doctors in your area that provide the service at Bosley.com.

Whether you go for the natural or chemical route, there are many options for stopping slow hair growth. In some cases the ingredients lists are so close that the only difference is in the price you pay for the product. Shop around and make sure you are getting the best possible deal for the treatment type you are interested in.

Whorush: 4 sites by this AdSense ID

Whorush: 4 sites by this AdSense ID

Whorush: 4 sites by this AdSense ID

Whorush: 4 sites by this AdSense ID

Thus far, the injection treatment has only been tested on lab mice. That is an important distinction to remember. The FDA admits that approval for actual human testing for the purpose of using this compound as a hair loss and regrowth product may be 5 to 10 years away.

It was these same researchers at UCLA that discovered the effects of antihypertensive medications on mice prior to its approval by the FDA. If the rate of growth detected in mice during the earlier study and in humans holds true, the preliminary results of Astressin-B in mice could signal a huge break through in the treatment for hair loss in women and men.


What interested the scientists most was how few treatments for hair loss and regrowth were needed and how long the treatments lasted. They injected mice with the chemical compound once a day for five days. They set them aside for three months speculating that this would be sufficient time to notice any change in the brain-gut interaction and what changes may have taken place. This is when they discovered that the bald mice had regrown all their hair. Additionally, the treatment was not needed again for four months.

There are currently topical creams on the market that have Astressin-B included in their ingredients. It has come to the attention of some medical specialists and the researchers, that some people are injecting these topical medications. The researchers have issued repeated warnings that these creams and ointments contain other chemical compounds that are designed to interact as a topical application. When hair products are not used as directed, they may be dangerous.

The research on Astressin-B is encouraging for all those with stress related hair loss and regrowth hopes. This blocker is not a stem cell product. This means that approval from the FDA may arrive more quickly since the hoops are not so many.

When you have hair loss, you want someone to talk to who understands what you are going through. You can learn a lot from other people who have been there and done that. In addition, it helps to vent your feelings and frustrations to people who understand them. This is why there are so many hair loss talk websites. These websites were designed for people just like you.
There are many hair loss talk websites out there, but not all of them are created equally. It is best to look around, check the forum posts and see if the community will be a good fit for you before posting. To help you on your way to your own hair loss talk, a list of the seven best websites for this purpose are listed below.

HairLossTalk.com – This website provides forums and a vast community of people who are also facing hair loss. People post their experiences and treatments they have tried. It can be a great place to gather information, or just a place to vent.

BaldTruthTalk.com – This hair loss talk website offers forums and a community for people who are going bald, or who are bald. It is a great place to make friends and share your feelings and frustrations with others.


HairLossHelp.com – Another website that offers forums, you will find a number of treatments reviewed by real people on this site. Learn what has worked for others and what might work for you.
ProgressiveHealth.com/HairLossTalk.htm – This is another forum where you can learn from the experiences of others as well as share your own experiences and feelings about your hair loss. You can easily overcome obstacles when you have a support group like this one.

HairLossBlues.com – This website features a wealth of information about hair loss, including a hair loss talk forum. You will get a number of responses from any post you make, and you will find support of all kinds within this online community.

HairLossForums.org – This website features many hair loss talk forums, based on what type of support you are looking for. Information from what causes hair loss to what can cure the condition is available from people who have really been there.

Hair-Loss-Guide.org – This website also has a lot of information as well as forums. A general hair loss talk forum is available for you to vent your frustrations and fears, while subject specific forums are also available for you to glean information from others in your situation.

Hair loss in aging men and women is characterized by these “damaged hair follicles.” Normal hair growth depends on a cycle in which periodic regeneration of the underlying hair follicle occurs through a process directed by stem cells.

Within the follicle, normal stem cell function is essential for hair follicle regrowth. What has been discovered in just the past few years, through studies of wound healing in burn victims and other patients, is that it is possible to actually grow new hair follicles and, as a result, new hair. The formation of new follicles and hair growth was shown to be associated with a cascade of cellular and biochemical events during the wound healing process.


By studying wound healing at the cellular and molecular levels, the skin was observed to have the ability to revert to a more primitive or “embryonic” state as progenitor cells “migrate” to the wounded area, restoring the regenerative capacity of the skin not previously thought to occur in adults.

The regenerative response includes new hair follicle formation, allowing new hair to grow at the restored site.

A major part of the wound healing cascade is the release of growth factors and cytokines from stem cells into the layers of the scalp at the site of the wound. These growth factors and cytokines function like a light switch, turning on lost or decreased function of the hair follicle.

Although dihydrotestosterone (DHT) is only one factor, and a minor one, in causing the unhealthy minaturization of the follicle in male pattern baldness process, it has received much attention. Several products are now on the market that attempt to restore hair growth based on interacting with the DHT pathway. These DHT specific products have demonstrated limited efficacy in growing new hair yet can show debilitating side-effects, including sexual dysfunction.

Based on the similar etiologies of male pattern baldness through DHT, it was thought that naturally occurring growth factors may also benefit the treatment of hair loss through the DHT pathway, but without the side-effects seen with other products. More importantly, the direct effects of topically applied cytokines and growth factors to the hair follicle restores the normal physiology and anatomy of the hair follicle and is the critical factor in restoring hair growth.

Below is the first example of a placebo-controlled, double-blind study undertaken to examine the benefit of these naturally occurring growth factors in the treatment of hair loss.

Objectives: The goal of this study was to test naturally occurring growth factors in the treatment of AGA.

Subjects included in this study were males between the ages of 25 and 65 years of age, in good health, with mild to moderate AGA.

Results: The results of this study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that over 90% of study subjects dosed with the active study formulation were rated as improved at the final visit. Patient self-assessment demonstrated that 94% of the patients saw significant improvement in hair growth and prevention of hair loss.

Conclusions: This study establishes the effectiveness of naturally occurring growth factors for the first time in the treatment of hair loss. Growth factor technology has been used to generate completely new hair follicles for the first time in normal adult males. The researchers were able to induce the regenerative response, including new hair follicle formation, by applying a combination of factors to the scalp. This work showed that the application of these growth factors resulted in skin triggered molecular pathways, allowing a new topical treatment option for re-growing hair.

Caution: the application of any artificially created or synthesized signaling molecule is discouraged for two reasons; they lack potency and they may cause unnecessary secondary side effects. A good rule of thumb is to stay as natural as possible.

Very qualified people, who have hair loss issues, experience the look of distaste on an employers face when they meet in person for that first interview. It comes as a momentary flash across the face that borders on distaste or disappointment. Women are more vulnerable than men. Women applying for a position where they are in direct public contact with the customers may not be hired because of this problem.

Approximately 45 million men and 10 million women in the United States have pattern baldness. Studies show that pattern baldness is caused by two factors coming together -= inherited genes and age of person. An Australian research project reported that the chance of inheriting the gene is 4 in 7 and comes from both parents. Because Pattern baldness is the foremost type of hair loss studied, the chances of growing hair again is better than in some other causes.


That is only one cause of hair loss. Other known causes are childbirth, major surgery, traumatic incidents, wearing ponytails or pulling the hair tightly, and diabetes. Those are only a few of the triggers that are confirmed. Regardless of the cause, most people would like to have hair again.

Several treatments for hair loss are available. Some work better for men. Others work better for women. Often, a combination of treatments is what it takes to grow hair again. All treatments in the United States require FDA approval before it can be made available to the public. There are surgical and non-surgical methods now proven successful.
Topical treatments, such as Minoxidil and Rogaine, work for approximately 20% of the people who use it. However, when combined with other treatment methods, the success rate increases by an additional 40% on average.

Another non-surgical method that has a proven record of accomplishment is low laser therapy. In some instances, this treatment is done at the clinic using a medical device. Other methods use a laser comb.

Hair transplants are effective for 90% of patients. Transplants may include either direct root transplanting or cloning methods. Cloning is the latest method and the results are less patchy in most instances. If you want information about how you can have hair again, fill in the form below:

The company is pushing ahead with its research despite increasing public skepticism that cellular regeneration of hair follicles will ever be a reality. Men and women who suffer from hair loss have been following the promise of hair cloning or hair regeneration for years now, with researchers always promising that each breakthrough will lead to a viable treatment soon. After the demise of the British company Intercytex, the hair loss community put its hopes in Follica, Histogen, Aderans and other companies promising a stem cell based approach to treating hair loss… all, so far, to no avail. The cynicism and bitterness among hair loss sufferers is reflected in the many hair loss websites in which every new treatment proposal is routinely derided as a “scam.” To date, the research that appears to be farthest along is that of Aderans, which recently enrolled its 300th subject in Phase 2 of its clinical trial of its Ji Gami™ process. According to the company, the treatment involves removing a small piece of tissue from a subject’s neckline. Hair follicle cells are then cultivated in controlled conditions where they are encouraged to multiply by the addition of proprietary growth media. When enough new cells are formed, they are returned to the scalp, where they are injected and elicit new hair growth and thickness, ultimately producing more hair than the client had before. The goal is to create a virtually limitless supply of new hair follicle cells that can be used for extensive hair transplantation.


It is into this murky research bog that RepliCel has launched itself. The company’s proposed solution sounds remarkably similar to that of Aderans. “A small biopsy is taken from the lower back area of a person’s scalp since these hair follicles are immune to androgen hormones in men, and through that, about 20 to 25 hair follicles are extracted,” explains one website. “The dermal sheath cup cells are then isolated from the hair follicles and replicated in a proprietary blend of culture media for as long as three months. The cells are then re-injected into balding areas on the patient’s scalp, and the procedure is essentially complete.”

In August, the company injected the final participant (9 women and 10 men) in its first Phase I clinical trial being conducted, strangely, in Tsibli, Georgia. If the trial is successful and RepliCel proves “efficacy” and safety by as early as March 2012, the company can then proceed to a Phase II clinical trial. The procedure produced an efficacy rate of 50% in mice and hopes to achieve an efficacy rate of 20% in people.

“The hypothesis for humans, which we’re now testing in Phase I, is that isolating and replicating autologous dermal sheath cup cells and then injecting them back into the patient will lead to not just follicular hair growth, but the rejuvenation of the existing quiescent hair follicles that have been miniaturized and essentially stopped cycling due to the androgens overwhelming the receptors on those cells,” explains CEO David Hall. “That’s what we’re trying to achieve.”

In the meantime, bald men and women who suffer from thinning hair wait… and wait… and wait.

We try to tell people that the research is exciting and new and continuing apace… that there are four or five major research efforts going on and that a major breakthrough in hair loss treatment may be only a few years away… but few people believe us.

Still, there is a very good reason for optimism: greed. Hall estimates that the overall hair loss treatment industry is worth about $2 billion, with micro-transplants accounting for over $1.2 billion and hair loss drugs accounting for about $1 billion. T”here hasn’t been a drug proven to effectively treat female pattern baldness, and Hall says women don’t typically elect to undergo hair transplant surgery,” notes Equities.com in its note on the company. “This translates into a significant opportunity for a safe, minimally invasive treatment to serve this unmet market. Given that RepliCel’s autologous cell-based procedure is designed to be a one-time treatment that requires very little involvement from the actual patient, it could be a much more attractive option than what is currently available.”

On November 30, the company announced that it would convert all 13 million shares of Class C stock into 2.6 million shares of common stock. All told, this will bring the total shares of common stock in RepliCel up to 43,150,006 shares, currently selling for $2.55 per share.

One of the primary ingredients in both ReGenrXx Hair Serum 90 and Luminessce Anti-Aging Serum is “Adipose Derived Stem Cells Conditioned Medium (ADSC-CM)”. This potent ingredient stimulates both collagen synthesis and migration of fibroblasts, and accelerates wound healing. Adipose derived stem cells are captured by extracting fat cells from human adults. In conditioned medium, the stem cells secrete growth factors (today there are 378 known growth factors that have been identified). Two major benefits of these growth factors contribute to both anti-aging and hair growth enhancement.

Visible aging of the skin occurs when collagen is diminished. However, collagen applied to the skin cannot penetrate the skin due to its molecular size ( they are too big to pass through the skin) and therefore can yield no beneficial outcome to slow or stop the aging process. Insulting the skin can and does increase collagen production as observed in deep phenol peels. However, growth factors formulated in cosmetic products are so small that in conjunction with “Penetration Plus Technology” they can penetrate through the outer layer of the skin and as signaling molecules they indirectly influence the growth or stimulation of collagen in the skin, potentially slowing, halting or even reversing the aging process.


In hair enhancement, the ability to influence fibroblast migration enables the release of more cytokines and growth factors in the scalp that act to wake up dormant stem cells in the hair follicles. These two major discoveries promise ongoing skin and scalp enhancement that may stop the aging and/or hair loss processes. Additionally, ADSC-CM shows promise for the treatment of cutaneous wounds and accelerates granulation formation during the healing process.

CyGenX captures these potent growth factors from the conditioned medium in their natural form without any alterations and formulates them in potent concentrations in all CygenX cosmetic products.
In my next article I will address why the introduction of these growth factors to the skin (the perfect human bio-reactor) via the CyGenX skin and hair serums, amplifies the potency and efficacy of these products yielding unmatched outcomes.

Signaling molecules, sometimes referred to as growth factors, are natural and naturally occurring secretions from stem cells that are assigned this communication task to stimulate the development and function of the progenitor cells that grow hair.

Many physicians and medical researchers agree that “potent” stem cells and their normal and normally secreted signaling molecules are the future of medicine. Many believe that this FUTURE is here TODAY. Many doctors and researchers also believe that stem cell derived growth factors and signaling molecules may hold the key to unlocking a permanent solution for hair growth and balding.

One of the recent discoveries that evolved from stem cell research is the isolation of powerful molecules that work like “light switches”. As these signaling molecules that are natural and naturally secreted from the stem cells come into proximity with “non” or “sub” functioning tissues and organs of the human body they “almost magically” repair the cells and tissues that were malfunctioning and restore them to their intended function.

New research has revealed that stem cells secrete a natural communicating or signaling molecule (BDNF) that improves synaptic communication. Now we know even more: for example, that there are more than 200 of these powerful molecules secreted by stem cells in the form of growth factors, cytokines and other communicating molecules, Wnt proteins, sonic hedgehogs, and so on, that perform similar functions in cells throughout the body.

These stem cell secretions that are “squirted” onto mal-functioning cells do so to heal the unhealthy cells and restore normal function. It appears not to be necessary, in most instances, to actually replace the cell.

Think for a moment about the complex organ of the hair follicle. It consists of many tissue types:  muscles, glands, skin (ectoderm and mesoderm), nerves, the hair bulb with stem cells. Each hair follicle is an organ and on the scalp there are hundreds of thousands of hair follicles.

When hair loss or balding occurs it is because this hair organ has been compromised. There are many reasons for this compromise but we will focus on one: the diminishing of the number of progenitor cells. Suffice it to say that the cause does not matter as much as the solution.

A study of stem cells has revealed something unheard of prior to knowledge of this advanced science. The body’s components have seemingly infinite abilities to heal all specialized cells in the body. When a tissue malfunction occurs, the medical physician performs a diagnosis and then prescribes a drug to combat that diagnosis. Sometimes this exercise results in the prescription of multiple different medical prescriptions because what one medicine relieves that medication can subsequently create new side effects that again may require yet another medical prescription and so on.

We tend to chase symptoms. The body focuses on solving the underlying problem. Stem cell researchers uncovered a small part of this big picture: that the natural secretions and naturally occurring secretions of stem cells can “squirt” the proper growth factor(s) in proper amounts to overcome and heal the tissue malfunction. If the researchers had waited to answer the question, “What caused this malfunction,” we would still be waiting for this valuable information. This does not mean to infer that the cause is not important. It is. However, it is not necessary to know the answer to that question in order to benefit from his discovery.

Stem cells are primitive cells that work like natural “little pharmacies” within the body that are standing by to heal the body’s damaged cells and tissues. These secretions are collected from Human Fibroblast Conditioned Media (HFCM). These secretions are generally referred to as growth factors, but they are more. In reality they are signaling proteins that communicate to enhance or repair a damaged cell or combination of cells. (NOTE: Human Fibroblast Conditioned Media (HFCM) is classified as a “0” risk as to safety in cosmeceuticals. This means that they are universally considered “safe” for human use.)

Hair growth is maintained through a process that includes stem cell regeneration of hair follicles. The hair cycle consists of three defined stages: growth (anagen), followed by regression (catagen) and rest (telogen). Growth of a new hair requires re-entry into the anagen phase, a process involving activation of multipotent stem cells in the hair bulge.  Activating signals originate from the dermal papilla, directing stem cells to regenerate the hair bulb, the structure from which a new hair will emerge. Multiple signaling pathways, including Wnts, Sonic hedgehog (Shh), and TGF-beta family members have been shown to promote anagen initiation. Gene’s interfere with this process and can result in premature balding. The external application of these signaling molecules from Human Fibroblast Conditioned Media (HFCM) appear to reconnect the lost signaling capabilities restoring the health to the impotent hair follicle.

Androgenetic alopecia (AGA) is characterized by the miniaturization of the hair follicles in susceptible individuals and occurs in a defined pattern on the scalp. Hair loss in aging men and women is characterized by these “damaged hair follicles.” Normal hair growth depends on the hair cycle where periodic regeneration of the hair follicle, occurs through a stem cell directed process. Within the follicle normal stem cell function is essential for hair follicle regeneration. In studies of wound healing in burn victims and other patients there were observed the formation of new hair follicles and associated new hair growth. The formation of new follicles and hair growth was shown to be associated with a cascade of cellular and biochemical events during the wound healing process.

By studying wound healing at the cellular and molecular levels, the skin was observed to have the ability to revert to a more primitive or “embryonic” state as progenitor cells migrate to the wounded area, restoring the regenerative capacity of the skin not previously thought to occur in adults. The regenerative response included new hair follicle formation, allowing new hair to grow at the restored site. A major part of the wound healing cascade is the release of growth factors and cytokines from stem cells into the layers of the scalp at the site of the wound. These growth factors and cytokines function like a light switch, turning on lost or decreased function of the hair follicle.

“If we can get these fat cells in the skin to talk to the dormant stem cells at the base of hair follicles, we might be able to get hair to grow again,”
– Dr. Valerie Horsley, Assistant Professor of Molecular, Cellular and Developmental Biology, Yale University

We now know that the hair follicles in balding men and women are not “dead” but merely sleeping. What’s more, we’re beginning to discover how to wake them up — which, despite all the delays and frustration, means we really are getting closer to a realistic stem cell treatment for hair loss. The key may lie in our fat cells. Here’s the scoop.

Researchers at Yale University recently discovered that men with male pattern baldness still have the stem cells that are necessary for hair growth. The hair stem cells lie in their follicle roots, but the cells are dormant and can’t spur growth. The researchers also discovered that the hair follicle stem cells need signals from within the skin to grow hair. The question is, where do the signals come from?

The answer: special proteins (growth factors) from stell cells deep in the fatty layer of the skin. The Yale researchers have been able to use these special proteins like a chemical switch and “turn back on” the hair stem cells in mice.

“[The Yale team] said there was a four-fold increase in the number of “precursor” fat cells in the skin around a hair follicle when it started to grow.
They looked at defective mice, which could not produce these fat cells. Hair normally grows in cycles, but in the defective mice, the follicles had become trapped in the dormant phase of the cycle.
Scientists injected fat cells from healthy mice into the defective mice. Two weeks later, hair follicles had started to grow.”

The researchers also found that the “precursor fat cells” were producing a platelet-derived growth factor — at 100 times the level of surrounding cells — that appeared to be kick-starting the follicles to grow hair. Injecting the growth factor into the skin of defective mice could trigger hair growth in 86% of follicles.

Of course, the researchers still have to show that the cellular signaling involved in human baldness are the same as they are in mice. If they are, the findings could help scientists develop a new stem cell baldness treatment.

There are a handful of companies that are actively pursuing a commercial viable stem cell therapy for hair loss or at least a stem cell treatment for hair loss. In no particular order, here are the top seven:

1. Follica: Stem Cell Hair Regrowth. Co-founded by George Cotsarelis, M.D., chair of the Department of Dermatology at the University of Pennsylvania School of Medicine, Follica has found that hair follicle stem cells are preserved in bald scalp from men. These findings, based on studies of human cell samples from bald scalp and non-bald scalp, showed that bald areas had the same number of stem cells as normal scalp in the same person, but lacked a more mature cell type called a progenitor. These findings support Follica’s approach towards treating androgenetic alopecia, which targets activation of stem cells to induce hair follicle neogenesis (re-growth).

2. Histogen: Hair Treatments for Hair Loss. Histogen, Inc., a regenerative medicine company developing solutions based on the products of newborn cells grown under embryonic conditions, is in the midst of clinical trials of its Hair Stimulating Complex (HSC. Statistically significant new hair growth was seen in HSC-treated subjects at this follow-up time point, one year after their single treatment with HSC. They are currently testing the safety and efficacy of their HSC product as an injectable for hair growth.


3. Aderans: Combatting Hair Loss in Men. Aderans Research Institute (ARI) is currently in the middle of Phase II trials of its much-anticipated, much-delayed new cellular hair regeneration technology. The company hopes to “encourage” follicular cells to reproduce themselves via a method ARI calls the Ji Gami™ process, resulting in a virtually unlimited number of hair-generating cellular units produced. During this process, a small piece of tissue is removed from the neckline. Cells are cultivated in controlled conditions where they are encouraged to multiply by the addition of proprietary growth media.

4. RepliCel: Regrow Hair. The Vancouver-based biotech company RepliCel Life Sciences is forging ahead with its clinical trials for hair regeneration therapies. The company was established on the research foundations of two scientists, Kevin McElwee and Rolf Hoffmann, who have done pioneering research into what are called dermal sheath cup cells. These cells are located in hair follicles and contain stem cell-like characteristics that, the scientists believe, have the potential to stimulate regrowth of non-producing hair follicles or regeneration of existing ones. The company’s proposed solution sounds remarkably similar to that of Aderans. “A small biopsy is taken from the lower back area of a person’s scalp since these hair follicles are immune to androgen hormones in men, and through that, about 20 to 25 hair follicles are extracted,” explains one website. “The dermal sheath cup cells are then isolated from the hair follicles and replicated in a proprietary blend of culture media for as long as three months. The cells are then re-injected into balding areas on the patient’s scalp, and the procedure is essentially complete.”

5. CygenX Treatment for Hair. Cygenx is one of the few companies now actively marketing hair growth serums based on growth factors ethically derived from adult stem cells. The stem cell lines are placed in conditioned media where cytokines, complex proteins and growth factors are secreted in a cultured laboratory environment. The company insists that its Tri-Mix Blend of Conditioned Media is novel and CyGenX® products are the only products made with this proprietary blend and concentration of follicle stimulating and enhancing growth factors.

]]> http://stemcellbaldnesscures.com/stem-cell-hair/stem-cell-hair-treatments-7-hair-stem-cell-companies-to-follow-in-2012/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-genesis-an-all-natural-hair-loss-treatment/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-genesis-an-all-natural-hair-loss-treatment/#comments Tue, 10 Jan 2012 20:11:52 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8547

Quite simply, Hair Genesis is an all natural hair loss treatment program. It combines vitamins for hair growth, a shampoo, and a serum treatment to provide a whole performance hair growth treatment program. However, Hair Genesis is anything but simple.

In fact, it is a complex combination of five alpha-reductase inhibitors. These all-natural ingredients have been scientifically tested and proven to “assist” in the treatment of hair loss in men, and thinning hair in women. In fact, according to the company, Hair Genesis is allegedly the first and only natural hair loss treatment program to test positively in double blind, placebo controlled study and in other scientific clinical trials.

Although the patent is still pending on this hair loss treatment program, Hair Genesis is available through its own website as well as several others around the internet. It is relatively inexpensive when compared to other hair loss treatment solutions. In addition, Hair Genesis is all natural, without the chemicals that can be found in other products.


There are four products in the hair loss treatment program. The first is the oral soft gels, which contain vitamins for hair growth such as saw palmetto, grape seed oil, and green tea extract. The second product in the program is the topical serum, which contains a number of herbs, vitamins and acids that stimulate hair growth. Finally, the program contains a special shampoo and conditioner, which are also formulated to stimulate hair follicles, generating thicker, fuller hair.

Recently, Hair Genesis was featured in a study that was published in a peer reviewed magazine. The study showed that the program could potentially outperform single product treatments. The article found in the Evidence-Based Complimentary and Alternative Medicine publication also purported that Hair Genesis is validated as a naturally delivered hair loss treatment product. It pointed out that the research, conducted since 1995, has continuously validated the product and the latest version of the product, Hair Genesis Five, and is the most advanced combination of natural ingredients yet.

Many consumers prefer natural ingredients and believe natural products are preferable for the health of the patient. In addition, some people are attracted by the multi-modal approach that Hair Genesis takes — using a combination of vitamins, shampoos and serum. Finally, the people who prefer Hair Genesis do so because they believe it works — which isn’t the same thing as saying it works for everyone, however. The company says that while you may begin to see benefits and improvements quickly, full hair growth can take several months.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-genesis-an-all-natural-hair-loss-treatment/feed/ 0 http://stemcellbaldnesscures.com/baldness-cure/replicel-how-to-grow-hair-even-if-youre-cue-ball-bald/ http://stemcellbaldnesscures.com/baldness-cure/replicel-how-to-grow-hair-even-if-youre-cue-ball-bald/#comments Sun, 08 Jan 2012 23:35:56 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8540 Replicel Life Science Inc. is developing a technology that may become the world’s very first, minimally invasive, permanent baldness cure. Replicel’s founders and researchers are from established universities in Canada and Germany and have studied immunology, hair biology and hair growth for more than two decades.

In 2000s, Dr. Kevin McElwee and Dr. Rolf Hoffman discovered that dermal sheath cup-derived stem cells could potentially induce the formation of new hair follicles in animals as well as better quality hair growth. A patent for this discovery was filed in 2003, and is accepted in Europe and Australia and is now pending in the Canada, Japan and the United States. Replicel’s current work involves translating this discovery into a permanent hair loss treatment, perhaps even a baldness cure. The procedure has been in the development phase for the past nine years.

This hair loss treatment works by using autologous cell implantation technology; dermal sheath cup cells from a patient’s own healthy hair follicles and are replicated into the millions over a three-month period. These cells are reintroduced into areas affected by hair loss and theoretically this should cause the development of new hair follicles.

Currently Replicel’s treatment can potentially be used as a baldness cure for both men and women, trauma induced hair loss, traction alopecia, chemotherapy induced hair loss, scarring alopecias, congenital alopecia and congenital hypotrichoses.


The hair loss treatment was first tested on mice and proved to be safe and effective. Human clinical trials are being carried out at the moment. The primary aim of these trials is to determine whether this treatment can provide a safe and reliable hair growth solution. The trials will be divided into two phases, the efficacy and safety of the treatment will be studied in the first phase and the second phase will involve a larger number of participants and the amount of dose will be manipulated.

If it is found to be effective and safe in the human trials, Replicel’s stem cell hair loss treatment may not only provide hope for those suffering from different types of balding, but it can also be very profitable. It being a non-invasive treatment and not involving any animal products will make it popular among people with different religious beliefs.

In conclusion, Replicel’s procedure as a permanent hair loss treatment does seem promising in the light of the research that has been carried out but more human clinical trials need to be carried out before a final verdict can be given.

]]> http://stemcellbaldnesscures.com/baldness-cure/replicel-how-to-grow-hair-even-if-youre-cue-ball-bald/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/what-is-prp-and-how-does-it-grow-hair/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/what-is-prp-and-how-does-it-grow-hair/#comments Sat, 07 Jan 2012 22:04:52 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8525 What is PRP exactly? And how does it grow hair? And what does Acell Matristem have to do with all this? Well, those are all good questions.

Let’s start with Acell Matristem first. Accel Matristem is a Food and Drug Authority cleared extracelluar matrix (ECM), wound-healing powder from pig bladders developed by ACell Inc. It is used for tissue regeneration and the end result looks more like normal skin rather than a scar. In 2010, CNN reported that a woman in the United States managed to regrow her finger by using this particular treatment. Since then, ACell Matristem has gained a lot of popularity and many people have reportedly used it for tissue regeneration.

In recent years, scientists and researchers have started speculating whether ACell Matristem can be used to grow hair. Theoretically, it works by converting the site of injury into active progenitor cells. It also sets up non-cross linked temporary scaffolding for the tissue regeneration that mimics the surrounding damaged tissue. This scaffolding contains and slowly releases growth factors. The ACell also contains necessary materials for remodeling including Collagen 4.


Moreover, ECM has been shown to promote rapid tissue remodeling by promoting growth of new blood vessels and recruiting host-derived cells that lay down collagen and potentially promote the formation of hair. This results in quicker healing of wounds and less scarring.

Hair growth studies using ACell Matristem have been carried out and have shown increased hair density in participants. Although ACell Inc. did not originally create this treatment for hair growth; it seems to be useful in that aspect and definitely looks promising. According to Dr. Gary Hitzig, if ACell Matristem works as predicted the hair loss treatment industry may be changed forever.

However, like any other scientific research, ACell Matristem is not without critics. Dr. John Cole, a surgical hair treatment expert, critiqued that though there is evidence that ACell can regenerate hair in extraction sites, more work is necessary to ensure that this will always happen. Furthermore, there is no evidence regarding the ability of ACell to improve the growth of plucked hair or improving the growth of transplanted hair.

Overall, the usefulness of such a hair loss treatment cannot be denied but one must take into account that this particular treatment involves the use of healing powder that is obtained from pigs’ bladder and as a result certain religious factions may not support this treatment and will not be able to utilize it. Hence, this matter should be looked into. However, from a purely scientific point of view ACell Matristem is a great way for triggering new hair growth.

As for what is PRP, it stands for Platelet-Rich Plasma (PRP) — blood plasma that has been “enriched” with platelets and that contain several different growth factors and other cytokines that stimulate healing of bone and soft tissue. Some doctors claim that PRP can also stimulate additional hair growth when used in conjunction with hair transplant surgeries.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/what-is-prp-and-how-does-it-grow-hair/feed/ 0 http://stemcellbaldnesscures.com/products-for-hair/products-hair/aderans-research-institute/treatment-for-hair-loss-aderans-research-reports-on-hair-cloning-technology/ http://stemcellbaldnesscures.com/products-for-hair/products-hair/aderans-research-institute/treatment-for-hair-loss-aderans-research-reports-on-hair-cloning-technology/#comments Thu, 05 Jan 2012 19:07:43 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8221

Aderans Research Institute (ARI) is currently in the middle of Phase II trials of its much-anticipated, much-delayed new cellular hair regeneration technology. The company hopes to “encourage” follicular cells to reproduce themselves via a method ARI calls the Ji Gami™ process, resulting in a virtually unlimited number of hair-generating cellular units produced. During this process, a small piece of tissue is removed from the neckline. Cells are cultivated in controlled conditions where they are encouraged to multiply by the addition of proprietary growth media. When enough new cells are formed, they are returned to the scalp, where they are injected and elicit new hair growth and thickness, ultimately producing more hair than the client had before. Candidates for hair regeneration may no longer be limited by the number of hairs on their head. ARI envisions a time when crowns (vertex) can be covered with full, natural hair regardless of the degree of hair loss.

The cell multiplication process, which involves a proprietary technology and “cooking” process, takes about 10 to 20 days. The cells are produced in ARI’s 8,000-square-foot laboratory facility in Atlanta, Georgia.


Conventional hair loss treatments, including hair transplants, run into a common problem: The limited amount of hair on a person’s head limits the degree of “redistribution” possible with transplants. For men with severe male pattern baldness especially, there is often an insufficient amount of hair remaining on the back of the head to provide a cosmetically satisfying result.

ARI’s new hair cloning technology could solve this problem… if it works. Several attempts have been made to create a viable hair cloning technology but the results, so far, have been limited. A common problem is that the hair that results tends to be very fine which also does not provide a cosmetically pleasing result.

ARI’s Phase II trial, which began in late 2008 and concludes in 2012, monitors patients for a full year after they have been injected with the regenerated cells. More than half the study participants so far have shown “significant” hair growth one year after administration, the company says.

“Interim data from the early stage of Phase II shows that about 50 to 70 percent of trial subjects are responding at a level that’s at least as good as anything that’s out there for growing hair, and we expect the later stage to get even better,” CEO Ken Washenik, Ph.D., said.

ARI treatments are entirely autologous. That means that ARI only attempts to generate hair growth using the participant’s own hair cells. No foreign growth media, such as plant- or animal-derived growth factors, are involved. When the cultivated follicles are restored to the participant’s scalp, he or she is receiving only his or her hair cells. This serum-free process delivers a degree of safety from complications unique to the field, the company says.

So far, Aderans has invested an estimated $100 million in its follicle cell multiplication technology and expects to spend an additional $50 million. The company is owned by the Japanese conglomerate Aderans Co., Ltd., the world’s largest manufacturers of wigs, which also owns the hair transplant giant Bosley.

To see more on ARI’s hair cloning technology, watch the update on the company’s hair multiplication technology presented by Dr. Ken Washenik during the 4th International Congress Research Against Hair Loss.

]]> http://stemcellbaldnesscures.com/products-for-hair/products-hair/aderans-research-institute/treatment-for-hair-loss-aderans-research-reports-on-hair-cloning-technology/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/the-truth-about-sulfate-shampoo-and-hair-loss/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/the-truth-about-sulfate-shampoo-and-hair-loss/#comments Thu, 05 Jan 2012 05:15:43 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8434 There are many misconceptions about sulfate shampoo and hair loss. Most shampoos contain a combination of a surfactant and an antisurfactant, which act together to create the cleansing lather which most people associate with a good shampoo. The surfactant itself is a molecule that can “grab onto” water with one end and grease with the other, allowing grease and dirt to be rinsed away in water. The surfactant most commonly used in most shampoo brands is a compound called sodium lauryl sulfate, which for most people is a harmless substance, but which can cause skin irritation in some cases. Particularly for people with very sensitive scalps, and those who are experiencing hair loss, it might be advisable to switch to one of the many available varieties of shampoo which don’t contain sodium lauryl sulfate, and see if the switch seems to provide relief.

The truth about this compound, with regard to its effect on hair loss, is actually that opinions are divided and no one has been able to offer definitive proof either that sodium lauryl sulfate is or is not a contributing factor to hair loss. It is a fact that the compound is used in some laboratory environments specifically as an irritant in cases where responses to skin irritation are being measured in lab animals. Having said that, the levels of the compound being used in these cases are considerably more concentrated than what a person would find in any shampoo. The idea that irritation caused by sodium lauryl sulfate could contribute to balding is certainly a feasible one from a physiological standpoint. If hair follicles in the scalp are reacting to an irritation, they may shed hairs as part of that reaction, resulting in exacerbated hair loss and balding.


It is unlikely that any shampoo would be a primary cause of balding, but it could be an aggravating factor which could accelerate the loss of hair. A person who is experiencing hair loss–and who wishes to avoid any measures which might worsen the problem—would do well to switch to a sulfate free hair product or sulfate free shampoo which doesn’t include sodium lauryl sulfate among its ingredients. Many products now offer alternative ingredients which perform the surfactant function in place of sodium lauryl sulfate, so a person who may be oversensitive to the compound can find a substitute easily, and at little to no extra expense. It may be that the sodium lauryl sulfate hadn’t been contributing to hair loss at all, but a person can cover those bases without losing anything.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/the-truth-about-sulfate-shampoo-and-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/progress-report-2012-hair-loss-research-and-studies/ http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/progress-report-2012-hair-loss-research-and-studies/#comments Thu, 05 Jan 2012 01:22:14 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=9389 Hair loss research has really taken off since reports of several studies done independent of each other emerged in 2007 and 2008. When the news of stem cell research for hair restoration became news, millions of men and women wanted to know how long it would be before they could get it.

Stem cell research is not the only major project developing for 2012 in this area. Transgender hair cloning, allows the implanting cells from any person and either gender — as opposed to using one’s own cells (autologous). Studies for topical solutions for women are in the works and treatment to block DHT. All said, 2012 appears to be an exciting year for hair loss restoration.

Last year, the testing of stem cell implantation had been substantially completed on mice but no human testing was on the front burner. In Late November 2011, a major financial magnet decided to fund human trials for stem cell research. The study is called Project Norma and further information will be forthcoming by mid-2012 with specific details. This method is expected to be less invasive and more effective for hair loss victims.


Intercytex, a U.K. company, announced limited success in a small human trial in hair cloning research. The research focuses on Transgender Hair Cloning. Unlike any other methods being developed, this method allows anyone to act as donor of the original follicular cell for reproduction. Additionally, the implanted follicular cell grows the natural hair color of the recipient, which is unseen in other research. There have been no reported issues of rejection.

In Germany, a team of researchers have reported remarkable success using melatonin treatment for women with diffuse or androgenetic hair loss. This was developed as a topical solution applied once daily in a double blind study using 40 women. They documented both anagen and frontal hair regrowth with a success rate of 90%. Likewise, it had no effect on male balding.
In the hair transplantation arena, Restoration Robotics is designing and manufacturing new surgical equipment that would allow for faster and cheaper traditional transplants. The cost of hair loss restoration using hair for transplants currently costs between $12k and $25k for the entire procedure.

Not to be outdone, pharmaceutical companies such as Johnson & Johnson, Merck, and Pfiser are improving the hair loss reduction products that they already have on the market. Add to that the DHT blocker that AndroScience, Corp. has in the pipeline and 2012 looks to be a year of major progress for hair loss victims.

]]> http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/progress-report-2012-hair-loss-research-and-studies/feed/ 0 http://stemcellbaldnesscures.com/hairs-lost/when-the-daily-number-of-hairs-lost-is-significant/ http://stemcellbaldnesscures.com/hairs-lost/when-the-daily-number-of-hairs-lost-is-significant/#comments Wed, 04 Jan 2012 01:15:56 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=9387 On average, a human scalp sheds approximately 100 hairs per day. When the number of hairs lost in continuous and significantly more than that, you should be concerned. The root cause may be a temporary condition that needs no treatment at all. On the other hand, if it continues for more than a month, a doctor’s diagnosis is needed.

Hairs lost after childbirth is a normal temporary increase. It may also occur as a side effect of some hormonal birth control medications. When it lingers after a few months, it may indicate a disease known as female hair pattern baldness. This can be treated in a variety of methods including low-laser treatment with topical solutions.

Women’s pattern baldness is usually seen as thinning in the early stages followed most often by hair clumping. The hairs lost during clumping may be enough to actually fill your hand. This type of hairs loss requires professional medical treatment rather than home remedies.

In temporary issues, a high protein diet may restore part of the protein being drained from the hair follicles to feed the rest of the body. However, this dietary change is unlikely to restore the hairs lost already.


A recent study by doctors in Jena, Germany, has discovered that melatonin replacement therapy is very successful in women’s balding issues. If there are large areas of hairs lost due to alopecia diseases, this could be an effective cure. The commercial production is expected to be released sometime in late 2012.

Younger women who wear hair styles that pull the hair tightly back, as well as women who wear wigs frequently, experience significantly higher numbers of hairs lost due to the pulling of the hair. Another common reason for temporary increase in shedding, especially with children, is high anxiety and stress.

Doctors are seeing more and more increase in hairs lost with children who live in abusive environments. This symptom may be a signal to teachers and doctors that cursory investigations by them should be considered. The other reason that this is showing up in children is because they pull and twirl their hair when bored or nervous.

The bottom line is that paying attention to when and how often huge amounts of your hair falls out when brushed or combed is important. The earlier balding issues are diagnosed, the better success current treatments produce. When you run your hands through your head, if the numbers of hairs lost in the action are more than you can count, get help.

]]> http://stemcellbaldnesscures.com/hairs-lost/when-the-daily-number-of-hairs-lost-is-significant/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/how-to-hair-growth-for-2012-7-steps-to-take-right-now/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/how-to-hair-growth-for-2012-7-steps-to-take-right-now/#comments Tue, 03 Jan 2012 20:55:40 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8417

Hair Fall Remedies – How to Hair Growth for 2012 can be outline in just 7 easy steps.

Step #1: Stop using shampoos with sulfates! Chemical additives in shampoos known as sulfates (sodium laureth sulfate and ammonium laureth sulfate) are what cause the lather most people expect when they use shampoos. Sodium Lareth Sulfate (SLS) is a powerful degreaser that is also used to clean garage floors and car engines. Unfortunately, these chemicals tend to dry out your hair, strip it of its color and, worst of all, may damage delicate hair follicles in people with a genetic predisposition to hair loss. The evidence suggests that sulfates irritate the skin and should only be used sparingly and in small concentrations. The problem is, most people in developed countries wash their hair often and use copious amounts of shampoo. What sucks is that virtually 98% of all commercial shampoos use sulfates. The exception are shampoos designed specifically for people who have their hair dyed. Many brands imply that they are sulfate-free but are not. I personally like the Coloresse brand of volume shampoo “for fine, thin, color-treated hair.” Buy it or something like it. Throw all your other shampoos and conditioners in the garbage.

Step #2: Begin taking biotin and other hair vitamin immediately. Research suggests that the top vitamins for hair growth are Biotin, Folic Acid, Vitamin B-6, Zinc Oxide and Pantothenic Acid. In otherwise healthy individuals, nutritional factors appear to play a role in people with persistent increased hair shedding. The role of the essential amino acid, l-lysine in hair loss also appears to be important. Double-blind data confirm the findings of one study in women with increased hair shedding, where a significant proportion responded to l-lysine and iron supplements. Bottom line: Take a good general “hair and nail” vitamin supplement such as those available at Costco and many other discount pharmacies.

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Step #3: Begin using a laser for hair growth. Low level laser therapy (LLLT) is among the most exciting new options in the treatment of hair loss. European studies have shown that LLLT stops hair loss in 85% of cases and stimulates new hair growth in 55% of cases. As a result, in 2007 the FDA approves the use of LLLT as a treatment for hair loss. A 2009 study of the HairMax Lasercomb found significant improvements in overall hair regrowth were demonstrated in terms of patients’ subjective assessment after 26 weeks of using the product.

Step #4: Use a good anti-DHT topical agent for hair growth. DHT, or dihydrotestosterone, is believed by most experts to be one of the principal causes of hair loss. More precisely, doctors people that people who suffer hair loss may have a genetic hyper-sensitivity (a kind of allergy) to DHT that causes the minaturization of hair follicles that leads, eventually, to hair loss. One strategy for dealing with this problem (at least in men) is the use of an oral medicine that limits DHT throughout your entire system. However, this approach has drawbacks because there is some evidence that some men can experience negative side effects from many hair fall remedies, such as impotence. Another approach, therefore, is to use anti-DHT topical agents directly on the scalp… and this has shown some success.

Step #6: Consider using a dermaroller with a doctor’s supervision. A doctor’s supervision is required because of the possible risk of infection in the scalp. In recent trials, over a 3 month period men treated with a dermaroller experienced an increase in hair growth. Some experts warn against this. Talk to your doctor. We do not recommend anyone use a dermaroller (which puts tiny holes in your scalp) without consulting a physician first.

 

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/how-to-hair-growth-for-2012-7-steps-to-take-right-now/feed/ 0 http://stemcellbaldnesscures.com/ovation-hair/ovation-hair-not-the-best-choice-for-hair-loss-or-thinning-hair/ http://stemcellbaldnesscures.com/ovation-hair/ovation-hair-not-the-best-choice-for-hair-loss-or-thinning-hair/#comments Mon, 02 Jan 2012 20:22:57 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8404 Ovation Hair, the company behind Mega-Tek and Ovation Hair Therapy, created quite a buzz in the hair treatment community with their aggressive marketing and radio ad campaigns in 2008. In the end, it seemed like much ado about nothing and the Ovation Hair Therapy did not prove to be as successful as its counterpart Mega-Tek, which was meant for horses but is reportedly used by people.

Ovation Hair Therapy system promotes a shampoo, hair therapy hair treatment and a cream rinse moisturizer regime. Following this regime reportedly causes hair to grow at an increased rate. The product that causes the hair growth is the Ovation Hair Therapy hair treatment. The active ingredient in the treatment formula is Panthenol, a pro vitamin that is a natural constituent of healthy hair. According to research, Panthenol has a moisturizing effect and can repair damaged hair but does not support hair regrowth.

Due to its promising claims, many women have turned to this product in hopes of improving their hair condition. However, a point to be considered is that this hair growth product is not FDA (Food and Drug Administration) approved which makes one question its claims. Overall the product has received mixed reviews, with many negative reviews along with positive. Some users have reported positive short-term outcomes but negative long-term results.


Moreover, the American Hair Loss Association does not recommend this product. Hence, it should be used with caution because there might be a plethora of problems waiting to erupt. The company’s site also does not clearly indicate if the product prevents hair loss and causes growth or whether it leads to regeneration and subsequent growth. In addition, not enough evidence is available regarding whether the hair growth product can be used on it own or must it be used with the whole package, including the shampoo and the cream rinse moisturizer.

Since the relevant associations have yet to approve this product, some other points that need to be considered are whether this product can be used in conjunction with products from other companies or will that cause allergic reactions. At the moment some side effects to the hair growth treatment product reported by consumers include dry scalp and excessive hair loss.

Overall the product has failed to deliver its promises of causing hair growth. Consumers have to keep in mind that an effective marketing campaign and a well organized website are not the main ingredients of a product and it is important for a product to be approved by the relevant authorities.

Susan Thompson writes about hair loss issues.

]]> http://stemcellbaldnesscures.com/ovation-hair/ovation-hair-not-the-best-choice-for-hair-loss-or-thinning-hair/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/will-2012-finally-see-stem-cell-cure-for-hair-loss/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/will-2012-finally-see-stem-cell-cure-for-hair-loss/#comments Sun, 01 Jan 2012 20:07:17 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8402 Stem cell research has been the center of attention in the scientific world for the past few decades. This promising yet highly controversial research has also been the subject of many scientific debates. While it may hold the key to many incurable diseases, there is still a long way to go before a stem cell cure may be made available to the public.

For many years, a stem cell cure was completely out of question due to the controversies surrounding the topic because of its extensive use of embryonic stem cells and low success rate. However, more recently, scientists have been trying to revert differentiated cells from adult donors into their pluripotent form for the purpose of their research. However, to date, success rate of such research remains low.

A lot of research has been done regarding stem cells including their ability to cure hair loss. In a study conducted by the Hair and Scalp Clinics in Clearwater, Fla. researchers showed some promising results in people suffering from Alopecia Areata. The basis of this study is stem cell research and it uses the patient’s own platelet-rich plasma. Although, the study has shown some positive immediate effects, long-term effects and side effects remain unknown.


Another recent study reported by the Journal of Clinical Investigation has shown that some signals need to be sent to the stem cells for them to regenerate hair. In the event that scientists can do this, a cure may become possible. Currently though, this study has only been conducted on men, and it is not known as to how females may respond to this treatment. The aforementioned research may seem promising but before one has to consider the plethora of research that has already been done yet yielded no concrete stem cell cure for hair loss. Case in point, the research done by University of Pennsylvania’s school of Medicine in 2004, which managed to isolate stem cells responsible for hair follicle growth treatments. At that point of time, it was considered very promising and was featured in various scientific journals. However, so far it has not resulted in a practical hair loss treatment.

In conclusion, it’s unlikely that 2012 will see a stem cell cure for hair loss. However, the research is continuing slowly but steadily. Stem cell research is slowly uncovering the actual mechanisms behind hair loss… and the more scientists discover about what causes the minaturization that leads to baldness, the sooner they will be able to develop treatments that stop these mechanisms in their tracks and even reverse them.

That is why most experts still believe that stem cell research to cure hair loss still looks promising. The “cure” we are all searching for will NOT come this year, in 2012, but may well arrive in this decade, before 2020. Stay tuned!

Susan Thompson is a health writer who blogs about hair loss technologies.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/will-2012-finally-see-stem-cell-cure-for-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/products-for-hair/what-teenagers-should-do-to-stop-hair-loss/ http://stemcellbaldnesscures.com/products-for-hair/what-teenagers-should-do-to-stop-hair-loss/#comments Sat, 31 Dec 2011 18:46:09 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8400 Hair loss is a fairly common problem among adults but it can also affect teenagers and, unlike adults, teenagers have a harder time dealing with it due to peer pressure and the unsaid need to look good. With a myriad of cures and medications available in the market, looking for a solution to hair loss may sound easy but finding a solution that will work for you is not as easy as it seems.

A normal teenager loses about 70 hairs a day and excessive hair loss is the body’s way of telling us that there may be a lack of nutrients or medical help might be required. To find a solution, one must first identify the root cause of the problem. There are four major types of hair loss that can occur in teenagers and each requires a different remedy.

Tinea Capitis, also known as scalp ringworm, is a contagious fungal infection and is one of the only types of hair loss in teenagers for which medication is necessary. Individuals suffering from this disease have small circular patches of hair falling out of random spots on their scalps. Due to the contagious nature of the disease, immediate medical help should be sought.


Traction Alopecia, occurring mainly in girls, is due to excessive use of hair products, treatments and tight hairstyles like cornrows. To prevent this type of hair loss, teenagers should avoid experimenting with hair products and treatments. Like adults, teenagers may also experience hair loss due to a poor diet, hormonal imbalance and stress. The solution to that would be to eat healthy and to minimize stress.

Other types of baldness such as male patterned baldness, characterized by a receding hairline or a thinning crown, may be genetic and occur in some teenagers around the age of 14. Medications and surgical treatments are not advised for teenagers due to ill side effects. Instead, teens should consider using non-sulfate shampoos, as a start. After consultation with a family doctor, they may be advised to consider products that contain topical anti-DHT agents.

In a nutshell, teens experiencing early hair loss should seek medical advice immediately. The exact cause should be identified and dealt with. Eating healthy, exercising, getting proper rest and decreasing stress are some of the basic ways to deal with hair loss. Some doctors also recommend using baby hair products as they are softer on the scalp and cold laser therapy. If excessive hair loss persists, expert medical attention, such as that provided by trichologists, should be sought.

Susan Thompson is a freelance health writer who writes frequently about hair loss issues.

]]> http://stemcellbaldnesscures.com/products-for-hair/what-teenagers-should-do-to-stop-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/gene-identified-in-male-pattern-baldness-may-lead-to-new-treatments/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/gene-identified-in-male-pattern-baldness-may-lead-to-new-treatments/#comments Wed, 28 Dec 2011 00:19:43 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8349 Thanks to researchers at Columbia, Stanford and Rockefeller Universities, a new treatment for hair loss that could result in hair regrowth may be on the horizon. The gene called APCDD1 is found to be the cause of a progressive form of hair loss that begins in childhood.

The hair loss is caused when the follicles go through a miniaturization process. The follicles shrink and become very narrow which results in the normal hair being replaced by fine hair sometimes referred to as “peach fuzz”.

Dr. Angela M. Christiano was the lead researcher from Columbia University and author of the study. She explained that by identifying the gene, researchers are able to better understand the process involved. Researchers are considering the possibility that this may also be a factor in Androgenic Alopecia, which may be the reason for hair loss in women, as well as men. She went on to say that even though the two diseases share certain similar processes physiologically that the cause of male patterned baldness is very complex and this may only be the tip of the iceberg.


The research involved analyzing data from a small number of families. The families were from Pakistan and from Italy and all had male patterned baldness in their hereditary line. The researchers discovered that the gene had a mutation in those that were affected by the disease. The gene is located on the genetic marker known as Chromosome 18.

It is this gene that blocks or inhibits the signals from one stem cell to another by causing a disruption in the signaling pathway. Prior to now, the pathway called a Wnt signaling pathway was only known to exist in mice. This is the first time it has been associated with human biology and linked to hair loss and regrowth. This means that hair growth patterns in mice and humans are more closely aligned than was thought previously.

Dr. Chritiano, who specializes in dermatology, genetics and development at Columbia University, was encouraged by this finding because it would suggest that a non-hormonal treatment for hair regrowth possible. She suggested that by learning to manipulate the Wnt pathways that treatments may help many more people than other treatments have been able to do so far.

The complexities of hair loss and hair growth is one that requires much more study. However, researchers are excited about the many new developments that have been discovered in the last year.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/gene-identified-in-male-pattern-baldness-may-lead-to-new-treatments/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/alopecia-areata-is-there-one-treatment-that-works/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/alopecia-areata-is-there-one-treatment-that-works/#comments Sun, 25 Dec 2011 23:41:51 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8335 Hair loss and the ability to regenerated hair growth has become an important study in genetics and stress related diseases in the last 30 years. Is there one treatment that really works is the question that most people that experience this highly emotional issue ask.

The short answer is maybe.

According to medical specialists in various fields, the treatment is dependent on the type of hair loss and regrowth ability within that causative issue. For example, Alopecia Areata is an acquired skin disease that is exacerbated by stress, which causes the autoimmune system to attack the hair follicles in those who have a pre-existing genetic predisposition to this specific attack.


There are a combination of treatments that may be helpful. However, it is common for the hair to return on its own in about a year. Dermatologists have used steroid injections, creams and prescribed shampoos as hair treatment for hair loss somewhat effectively. Still, because of spontaneous remission in so many cases, there is no clear evidence of the exact effectiveness of the treatments.

This chronic disorder is associated with hair loss in women as well as men. It is commonly seen after childbirth when the hair starts shedding more profusely. It is also seen in men. One of the distinguishing factors for both is that it does follow family members and suggests that there is a genetic link to this type of hair loss. Occasionally, a biopsy needs to be done to determine the precise diagnosis.

In September 2011, the report of recent studies by Yale researchers have discovered that there are stem cells in the fatty tissues of the scalp that communicate with the stem cells in the hair follicles and tell the hair to grow.

To date, there is no definitive method for preventing the disease. Additionally, in spite of rumors there are no known hair care products or treatments that have been shown to induce onset.

Hair treatment for hair loss is not a one size fits all proposition. Many of the reasons for this is because of the cause for that hair loss. Even though some products they may not work at all for the next. Researchers are leaning that hypertension may cause hair loss in some but may not affect others. Stress is showing that it is a significant factor regardless of the causative agent involved. The more scientists research hair loss, the more that they discover the reasons are many.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/alopecia-areata-is-there-one-treatment-that-works/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-multiplication-a-treatment-for-hair-loss/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-multiplication-a-treatment-for-hair-loss/#comments Fri, 23 Dec 2011 17:11:08 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=8323 Hair multiplication for hair loss/hair regrowth treatment is not the same as hair cloning. The hair cloning procedure is not approved for human testing or research at this point. The primary difference between cloning and multiplication is that cloning is done outside the body and multiplication is done in the scalp. Cloning uses genes and multiplication uses plucked hair or fragments of hair.

There are two methods for hair multiplication to stimulate hair regrowth. Both require implantation of donor hairs. In the first method, the idea is that when the donor hair is surgically placed into the scalp, the follicular cells in the scalp would regenerate. By doing this, the cells would activate the cells in the hair and cause multiplication of additional hair growth. In the second method, the same procedure is completed. The difference is that a stimulating drug is used activate additional cell growth. One problem seen in the second method is that the new growth come from the skin and not the hair follicle. The process has not been used long enough to determine if miniaturization will take place over time and kill the new hair.

What is being called “hair cloning” is in fact “hair cell implantation” if we want to be accurate. This method of hair regrowth has been developed by Dr. Amanda Reynolds and Dr. Collin Jahoda described this procedure in their paper “Trans-gender Induction of Hair Follicles.” The dermal sheath cells are removed and isolated from one person and then implanted into another person using injection techniques. These cells then stimulate creation of normal hair follicles. This treatment for hair loss can be done in greater numbers than the hair multiplication method.


The good news is that this treatment can be used for hair loss in women and the sheath cells can come from men. This is a huge breakthrough for women who experience hair loss disease. Repeat injections did not produce the anticipated rejection that is seen in other forms of multiplication methods – even when there was significant differences in genetic profiles.
Additionally, there were indications in the dermal sheath cell implantation that suggested that the skin of the recipient has some factor in the appearance of the hair. The hair regrowth may resemble the recipient’s natural hair more than that of that of the donor. This type of cell multiplication means that even those who are totally bald have the potential to regrow a full head of hair.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-multiplication-a-treatment-for-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/are-copper-peptides-a-legit-hair-loss-treatment/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/are-copper-peptides-a-legit-hair-loss-treatment/#comments Thu, 15 Dec 2011 22:18:12 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8316 Copper peptides are a natural complex consisting of three different amino acids called a tripeptide. This copper affinity can be found in human plasma, urine, and even saliva. The extraction of it can have significant positive effects for skin care and especially hair growth. The active ingredients found in copper peptides are folligen and tricomin. It helps to improve defenses in the skin and increase the supply of nutritional copper.

Copper peptides are typically expensive because it can offer a healthy environment to encourage hair growth. This stimulant is efficient and studies show it is non-toxic and does not irritate the scalp. This natural copper complex is so beneficial that research of copper peptides has extended to the areas of repairing DNA, regenerating nerves, and has positive effects on stem cell problems. A number of popular hair loss treatments, such as DS Laboratories Spectral.DNC and Revita and Revita.COR shampoos, incorporate copper peptides in their formulas.

Other uses of copper peptides include healing wounded animals, preventing cancer, and specifically, preventing further hair loss. Many traditional baldness remedies only work to decrease the dying of hairs but provide no attempts to increase the number of growing follicles. Copper peptides are continually researched because human trials have proven that there are health benefits and this natural copper complex can work extremely well for a variety of uses.


The unique benefit of copper peptides in relation to hair growth is that it can improve the overall health of the skin on the scalp by increasing blood circulation to the follicles. As men and women age, hair follicles become smaller and prevent vital amounts of oxygen and important nutrients to flow smoothly.

If the complexion of the skin itself is improved, hair growth will be affected because the two are interrelated. Furthermore, copper peptides can increase the size of the hair follicles thereby allowing faster growth and increased thickness of the hair shafts. Research has proved that as people get older, the fat accumulation under healthy follicles begins to diminish. Supported by multiple animal trials, copper peptides can drastically reduce and even eliminate this natural process.

The unique effects of copper peptides have prompted various patented hair loss products. It does not only prevent hair loss from continuing but it can actually reverse the natural process of follicle decomposition and eliminate pattern baldness in both men and women. Many studies have also concluded that copper peptides can restore hair for cancer patients who have baldness from chemotherapy. This natural complex is an affinity of copper and has definite benefits for treating hair loss.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/are-copper-peptides-a-legit-hair-loss-treatment/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/spectral-f7-astressin-b-topical-hair-growth-booster-now-available/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/spectral-f7-astressin-b-topical-hair-growth-booster-now-available/#comments Fri, 21 Oct 2011 14:52:42 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8272 DS Laboratories, the makers of the immensely popular Spectral DNC hair loss product, may have a full-blown blockbuster product on the horizon: The first-ever topical hair regrowth solution based on the recent discovery of the peptide Astressin-B, which was able to regrow hair on bald mice. The company’s first batches of the product sold out almost immediately… and is difficult to obtain.

The discovery of Astressin-B in February launched a flurry of media interest. Scientists at the University of California Los Angeles and the Veterans Administration announced that by applying a special peptide ( protein fragment) under the skin of mice that had gone bald due to overexpression of stress hormones they were able to regrow hair in almost all cases. The scientists believed that astressin-B blocked receptors for corticotropin-releasing factor, involved in the stress response, and led to hair regrowth. The data “support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress.” Translated: The scientists believe that Astressin-B can actually “reset” the mechanism that grows hair.

You can read the results of the study by clicking here.


The implications were not lost on observers. As one British blogger put it:

Apparently just a single daily shot of astressin-B for for five days maintains hair on a genetically-stress-bald mouse for up to four months – nearly a quarter of the mouse’s lifespan. If the same kind of effects are seen in humans, a course of anti-baldening pills or injections might maintain a luxuriant uptop rug for 15 or 20 years – at any rate where baldness results from the action of CRF-style stress related hormones. Encouragingly, CRF and associated compounds are found in human skin.

It remains to be seen whether Astressin-B will work as well for humans in the real world as it did for bald mice in the laboratory. Judging by how difficult it is to acquire DS Laboratories’s new product, however, it seems that people are willing to give it a try.

NOTE: You can see more information on a 3-month Spectral.DNC and Sprectral.F7 starter pack by clicking here.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/spectral-f7-astressin-b-topical-hair-growth-booster-now-available/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-transplant-restoration-with-follicular-unit-transfer/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-transplant-restoration-with-follicular-unit-transfer/#comments Fri, 21 Oct 2011 14:14:00 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8266 A standard follicular unit transfer operation requires the removal of donor strip of hair from the rear of the head from where the follicular unit grafts are examined under a microscope. These grafts are then preserved in saline and are then transplanted on a hair loss area on the crown area of the scalp.

Given the time consuming and exacting nature of this operation, a FUE surgeon is often able to transplant only about 400 to 600 follicular unit grafts per day. However, thanks to the FUE advances, this technique is often replaced by the follicular unit extraction (FUE). The cost per graft of FUE is approximately twice the cost of the standard operation discussed above but it is comparatively faster and minimally invasive.

Some FUE advances
In a FUE operation a small round punch is made in the donor area to directly extract 1, 2, 3 and 4 hair follicular unit grafts. The follicular units extracted using this process is ly referred to as “blunt dissection” where a punch is made to envelope the entire follicular unit separating it from the surrounding soft tissues.


Once the underlying follicular unit is separated from the surrounding tissues, it is easily extracted using a small forceps. The small holes left behind after the follicular unit extraction gradually heal over the next few days and are not detectable to the naked eye once the patient’s hair grows out. The healing time is much less than the donor strip extraction operation.
While the FUE operation has been adopted by most FUE hair replacement centers, the standard strip removal method is still the most popular FUE operation because it is more economical than the FUE.
Moreover, due to some FUE advances such as the use of trichophytic closure technique, the donor scar created by the strip removal operation is now often rendered almost undetectable to the naked eye. This advancement in the follicular unit transfer technique has made FUE operation relatively less appealing.

Follicular unit transfer research
Besides the FUE advances in the transplantation operations, a lot of research is also underway to clone the hair. If the follicular unit transfer research is successful it will be possible to make several copies of donor hair in the laboratory. The application of this technique would be used in the form of follicular unit transfer. In the traditional operations, the biggest limitation is often the donor which is not able to meet required density. However, hair multiplication promises to overcome this problem by having the amount of hair required to be grown in a laboratory from a single donor hair and then implanting it into the scalp.

Follicular unit transfer research for hair multiplication is very difficult and there are many hurdles that have to be overcome regarding the safety and cosmetic characteristics of the cloned hair. Some follicular unit transfer research has also provided breakthrough for some hair loss medication like Dutasteride.

There is no doubt that FUE procedures provide the best hair restoration possible… if the candidate has enough donor hair and is willing to bear the time and expense. Many people want to try non-surgical methods first, such as the new Spectral.F7 Astressin-B hair regrow serum recently announced. (For more information, click here.)

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-transplant-restoration-with-follicular-unit-transfer/feed/ 0 http://stemcellbaldnesscures.com/treatment-for-hair-2/capixyl-astressinb-new-hair-regrowth-ingredients-gaining-attention/ http://stemcellbaldnesscures.com/treatment-for-hair-2/capixyl-astressinb-new-hair-regrowth-ingredients-gaining-attention/#comments Wed, 19 Oct 2011 19:03:51 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8257

A Quebec cosmetics company, Unipex, has begun marketing a new hair loss ingredient that, it says, can stimulate new hair growth. The incredient, Capixyl, is a “biomimetic peptide” combined with a red clover extract. Based on the combined and synergistic action of its two ingredients, Capixyl supposedly prevents hair miniaturization, favors a better hair anchoring, and reduces inflammation, an aggravating factor in hair loss.

The company claims that clinical tests demonstrate Capixyl’s effectiveness in increasing the hair density by 46%. This makes Capixyl more effective for hair regrowth than many other products on the market, the company adds, and without causing side effects.


Unipex launches its Capixyl-based products in March. Unipex is a privately held company specializing in the development, production, marketing and distribution of active ingredients and specialty chemicals for world-class producers in the cosmetics, pharmaceutical, specialty chemical and nutrition industries.

More recently, another company, Divine Skin, launched the first product based on the peptide Astressin-B, a “hormone antagonist” that caused a lot of excitement earlier in 2011 when studies showed it regrew hair in stressed out mice. Astressin-B is meant to be used in conjunction with Divine Skins’s Spectral.DNC hair regrowth product and “nanosome” shampoo and conditioner. The first batches sold out within days. (The product will be available at the end of October. You can add your name to a no-obligation waiting list for a 3-month starter pack by clicking here.)

“Astressin-B is a very complex peptide that is difficult to synthesize,” said Divine Skin CEO Daniel Khesin. “So we are especially excited that the resulting product will be reasonably priced as well as cutting-edge, considering the extraordinary development schedule and cost.”

Astressin-B sparked extensive media coverage worldwide and excitement around the biotech industry after a clinical study, conducted by the University of California Los Angeles and the Veterans Administration, was published in February. By applying the peptide (a protein fragment) subcutaneously to mice that had gone bald due to overexpression of stress hormones, scientists showed that astressin-B blocked receptors for corticotropin-releasing factor, involved in the stress response, and led to hair regrowth.

“We think this technology is years ahead of its time,” continued Khesin. “It could provide significant benefits to many of our hair-loss customers. Spectral.F7 is another direct result of our relentless commitment to bring the latest technology to market first and always.”

Spectral.F7, a booster that can be combined with other treatments or used alone, should begin shipping at the end of October. It comes less than two months after Divine Skin introduced Nanoxidil, a new molecule designed to stimulate follicles at the vertex of the scalp and surpass hypertensive remedies for efficacy and tolerability.

]]> http://stemcellbaldnesscures.com/treatment-for-hair-2/capixyl-astressinb-new-hair-regrowth-ingredients-gaining-attention/feed/ 0 http://stemcellbaldnesscures.com/products-for-hair/receding-hairline-treatment-new-topical-astressin-b-hair-loss-treatment/ http://stemcellbaldnesscures.com/products-for-hair/receding-hairline-treatment-new-topical-astressin-b-hair-loss-treatment/#comments Thu, 22 Sep 2011 22:48:07 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8250

The biotech company Divine Skin Inc.announced the release of the first topical receding hairline treatment based on astressin-B, a peptide newly discovered to regrow hair on bald mice. Divine Skin becomes the first biotech developer to synthesize and commercialize the peptide for human use in a cosmetic product, to be marketed as Spectral.F7 under the DS Laboratories brand.

“Astressin-B is a very complex peptide that is difficult to synthesize,” said Divine Skin CEO Daniel Khesin. “So we are especially excited that the resulting product will be reasonably priced as well as cutting-edge, considering the extraordinary development schedule and cost.”

Astressin-B sparked extensive media coverage worldwide and excitement around the biotech industry after a clinical study, conducted by the University of California Los Angeles and the Veterans Administration, was published in February. By applying the peptide (a protein fragment) subcutaneously to mice that had gone bald due to overexpression of stress hormones, scientists showed that astressin-B blocked receptors for corticotropin-releasing factor, involved in the stress response, and led to hair regrowth.


“We think this technology is years ahead of its time,” continued Khesin. “It could provide significant benefits to many of our hair-loss customers. Spectral.F7 is another direct result of our relentless commitment to bring the latest technology to market first and always.”

Spectral.F7, a booster that can be combined with other treatments or used alone, should begin shipping in October. It comes less than two months after Divine Skin introduced Nanoxidil, a new molecule designed to stimulate follicles at the vertex of the scalp and surpass other remedies for efficacy and tolerability.

Divine Skin Inc. leads in the development of biotechnology for topical, nutritional, and pharmaceutical therapies. It markets worldwide through online and specialty retailers, cosmetics wholesalers, salons, and medical offices. The fast-growing company went public in 2009.

DS Laboratories, its flagship brand, offers high-performance topical solutions to restore growth and radiance to hair, suppress dandruff and unwanted hair, control acne, improve hygiene, and reduce cellulite and wrinkles. Bioavailability is enhanced through encapsulation.

For more information on ordering Spectral-F7 when it becomes available on December 26, 2011, click here.

]]> http://stemcellbaldnesscures.com/products-for-hair/receding-hairline-treatment-new-topical-astressin-b-hair-loss-treatment/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-news/new-treatments-for-baldness-scientists-find-stem-cells-that-tell-hair-its-time-to-grow/ http://stemcellbaldnesscures.com/hair-loss-news/new-treatments-for-baldness-scientists-find-stem-cells-that-tell-hair-its-time-to-grow/#comments Thu, 01 Sep 2011 17:46:46 +0000 http://www.sciencedaily.com/releases/2011/09/110901134641.htm Researchers have discovered the source of signals that trigger hair growth, an insight that may lead to new treatments for baldness.

]]> http://stemcellbaldnesscures.com/hair-loss-news/new-treatments-for-baldness-scientists-find-stem-cells-that-tell-hair-its-time-to-grow/feed/ 0 http://stemcellbaldnesscures.com/products-for-hair/hair-remedy-video-hightlights-acell-matristem-technology/ http://stemcellbaldnesscures.com/products-for-hair/hair-remedy-video-hightlights-acell-matristem-technology/#comments Fri, 05 Aug 2011 01:55:07 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8150

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]]> http://stemcellbaldnesscures.com/products-for-hair/hair-remedy-video-hightlights-acell-matristem-technology/feed/ 0 http://stemcellbaldnesscures.com/products-for-hair/my-hair-is-falling-out-why-is-my-hair-falling-out/ http://stemcellbaldnesscures.com/products-for-hair/my-hair-is-falling-out-why-is-my-hair-falling-out/#comments Fri, 05 Aug 2011 01:16:56 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8134 When I started to see that my hair is falling out, I naturally sought out hair loss treatments that other people have found useful. Here is what I found out.

Androgenetic alopecia (male and female pattern balding) is by far the most common cause of hair loss amongst men and a serious problem for many women. There are three important components which are responsible for both female and male balding:

1. A genetic predisposition for balding to occur.

2. Excessive presence of male hormones.

3. Aging – enough time for the first two factors to occur.

Both men and women produce male hormones that have a useful role to play in both sexes; but the fact that androgens occur in much higher concentrations in men explains why male pattern baldness is more common than the female balding.

What is making my hair fall out? It is metabolism of male hormones (androgen/testosterone) which is main cause of hair loss and male and female pattern balding both in men and women.

The metabolism of androgen involves an enzyme called 5 alpha reductase which combines with the hormone (testosterone) and converts it to DHT (Dihydro-testosterone). DHT is a natural metabolite of our body.

Why is my hair falling out? Some individuals, both men and women, are genetically pre-disposed to produce more DHT than the normal individuals. It is this accumulation of DHT and its effect on the cells inside the hair follicle and root which is one of the primary causes of male and female pattern balding.

When DHT gets into the hair follicle and root, especially a region called the dermal papilla, it changes the cell’ activity and prevents necessary proteins, vitamins and minerals from providing nourishment needed to sustain life in the hairs of those follicles. Consequently, hair follicles are reproduced at a much slower rate. This shortens their growing stage (anagen phase) and or lengthens their resting stage (telogen phase) of the follicle. DHT also causes hair follicle to shrink and get progressively smaller and finer. This process is known as miniaturization and causes the hair to ultimately fall. DHT induced androgenetic aloepcia is responsible for 95% of all hair loss.

Blocking the synthesis of DHT at the molecular level forms the basis for the treatment of MPHL (male pattern hair loss) and FPHL (female pattern hair loss). There are many natural DHT blockers and a number of drugs which are used for medical hair restoration.

There has been a great deal of progress in the field of hair replacement and restoration in the past few years. Surgical techniques have improved greatly from the days when hair replacement first began. All hair replacement techniques involve the use of your own hair; therefore, hair replacement candidates must have some healthy hair, usually at the back and sides of the head. The process is a relatively safe procedure when performed by a qualified surgeon, however as with any surgery there are risks. Candidates must be checked for uncontrolled high blood pressure, blood-clotting problems, or skin that scars excessively, as these conditions may make healing difficult. Small pieces of hair growing scalp grafts are removed from areas of the scalp with healthy hair and are placed where hair is thinning. There are three major types of grafts: punch grafts, mini-grafts, and micro-grafts. Punch grafting takes about 10-15 hairs and places them in the scalp. This was the first type of technique to be developed, and when first developed caused a patchy look in many candidates. The technique has been improved since the first days of being developed, and the new mini-graft technique has also been added as an option. Mini-grafts contain only 2-4 hairs per graft, and therefore look much more natural. Micro-grafts are still smaller grafts that contain one to two hairs each. To maintain healthy circulation of the scalp, grafts are placed 1/8th of an inch apart. Local anesthesia is usually sufficient for these procedures, and several procedures are usually required to achieve the desired result. Post-surgery, a period of approximately 10 days of no sexual or strenuous activity is recommended, as strenuous activity may cause bleeding from the graft areas.

Of course surgery is a serious option, and often an expensive one as well. For those not wishing to undergo surgery for either reason, the option of non-surgical hair additions is often explored. Many professionals have developed techniques to add hair to existing hair on your scalp that look very natural. Weaves, fusions, bonding, cabling and micro linking are some of the techniques used to bond hair to the existing hair or scalp non-surgically.

Many jokes were made in the past about wigs and toupees, and they have gained an unfavorable light amongst many people because they were so obvious on the wearer. Today’s toupees and wigs are often made of real hair and are very well styled, causing them to look ore natural on the wearer. These hairpieces are held in place by affixing adhesive to the scalp and stay in place through vigorous exercise. Of course you will need to seek a professionally made toupee in order to make it worth your while, and you should purchase at least two so that you can maintain them properly, servicing one while wearing the other. A professionally styled and fitted toupee is expected to cost upward of $600 to $1000 in today’s market. Of course no one wants to go through the embarrassment of wearing the obvious “rug” on top of your head, so if you are not willing to spend the money it takes to purchase a professional toupee then it is probably best to not wear any hairpiece at all.

Structured hairpieces as they are called are a semi-surgical approach that permanently attaches hair to the scalp by stitching the hair to the bald scalp. This procedure is not recommended, as it is a process that involves introducing a foreign material to the scalp. Most ethical surgeons do not perform this procedure any longer as they are generally deemed to be ethically inappropriate. If this procedure is recommended to you, get a second opinion from a trusted physician.

A much safer procedure is hair weaving, yet this can only be used if hair is thinning and large balding areas are not present. The process is also called hair intensification or hair integration. Strands of synthetic or real hair are braided or weaved into your own existing hair giving an appearance of a full head of hair. This procedure does have its drawbacks, because it can make the scalp difficult to access, interfering with proper hair and scalp maintenance necessary for the health of your remaining natural hair, and this method can also stress existing hair since the artificial hair introduced through weaving is attached to it. This method is usually expensive, costing several thousand dollars per application, and being that because of the aforementioned drawbacks it can only be left in for a few weeks at a time it is usually impractical for the average person.

It is highly recommended that one seek professional assistance with these procedures from licensed beauticians or barbers, and have a patch test done to the skin if using adhesives to test for skin sensitivities. Extra care must be taken to maintain cleanliness of the hair and scalp when wearing added hair in order to maintain the health of existing hair and the scalp in general. Of course, if you are undergoing chemotherapy or are in the early stages of diagnosed alopecia areata then these procedures should be avoided as the hair they are connected to is likely to fall out as well. Either waiting for a period of time or obtaining a full prosthesis is recommended in these cases.

Yet still there is another type of treatment which is a spray of micro fibers made up of the same substance that hair is made of: keratin. If your hair is simply thinning, while you are investigating a more permanent solution to your hair loss problems or in the process of employing a particular process that takes some time, you can use these substances to cosmetically produce the appearance of thicker and fuller hair. The substance is marketed under several different names, one such being Topik®. Being a temporary solution it is relatively inexpensive, and can provide some immediate aesthetic results to bolster confidence and optimism as you work on more permanent solutions.

]]> http://stemcellbaldnesscures.com/products-for-hair/my-hair-is-falling-out-why-is-my-hair-falling-out/feed/ 0 http://stemcellbaldnesscures.com/treatment-for-hair-2/treatment-for-hair-recoverup-uses-stem-cells-for-better-transplant-results/ http://stemcellbaldnesscures.com/treatment-for-hair-2/treatment-for-hair-recoverup-uses-stem-cells-for-better-transplant-results/#comments Wed, 27 Jul 2011 17:05:20 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=7907

Recoverup offers a new ethical, safe and effective long-lasting treatment for hair stem cell hair regeneration treatment that is the revolutionary solution to hair loss; taking stem cells from your own body and transforming them into enduring new hair. The treatment is available today.

The treatment uses Autologous Adipose Adult (A.A.A.) stem cells. Using A.A.A. derived stem cells helps you avoid ethical and moral barriers to stem cell usage by using stem cells taken from your own body. However, not only are A.A.A. stem cells more ethically preferable, they are also safer and more effective than other stem cells, such as those taken from human embryo’s or animals sources.

The procedure stimulates the growth of brand new hair, by placing the A.A.A. stem cells, in pores under the surface of the scalp. The treatment is minimally invasive and can be done in a day.

 

]]> http://stemcellbaldnesscures.com/treatment-for-hair-2/treatment-for-hair-recoverup-uses-stem-cells-for-better-transplant-results/feed/ 0 http://stemcellbaldnesscures.com/products-for-hair/researchers-report-on-latest-findings-on-astressin-b/ http://stemcellbaldnesscures.com/products-for-hair/researchers-report-on-latest-findings-on-astressin-b/#comments Mon, 04 Jul 2011 19:17:48 +0000 Paul Martin http://stemcellbaldnesscures.com/?p=7809 Hello guys, we are sorry for taking so long to follow up on our tests but it’s been a hectic and exciting time for us. So far we are hitting the 1 month and 2 weeks of our trials, and I must say that in all of my investigations I have never seen anything so promising.

We have not been able to replicate the exact ideal conditions for the tests, but we have been working well with what we have.

I don’t want to elaborate on specifics yet as it’s very early to say, but there is no doubt that Astressin has an unusual impact on stopping further hair loss on our subjects.


It’s important to note that the mice we are testing have strong levels of stress present in the system, the main culprit for their present conditions; this inequitably proved the overwhelming impact of stress in the hair growth process, it can potential mean that we have found an amazing compound that counteracts this effect and can potentially be used in future treatments.

Now we have been receiving a lot of emails asking how astressin would affect specific Androgenic Alopecia patients. Would love to have an answer but it’s really too early to say, what I can say for sure is that while stress can trigger an onset of MPB, it is not certainly the only factor, so a lot testing still needs to be conducted.

The next 2 months will be crucial, as we will be changing the testing environmental conditions but most importantly test on subjects with different conditions, some of which don’t involve a pre-existing elevated stress levels.

Will keep you updated, and to everyone that is feeling down and on the downside of advantage, there is hope, and I wouldn’t be saying this if I did not strongly believe we were dealing with a potentially game changer here.

]]> http://stemcellbaldnesscures.com/products-for-hair/researchers-report-on-latest-findings-on-astressin-b/feed/ 0 http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/wnt-signaling-may-end-grey-hair-baldness/ http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/wnt-signaling-may-end-grey-hair-baldness/#comments Mon, 04 Jul 2011 18:44:37 +0000 Paul Martin http://stemcellbaldnesscures.com/?p=7800 A new study by researchers at NYU Langone Medical Center has shown that, for the first time, Wnt signaling, already known to control many biological processes, between hair follicles and melanocyte stem cells can dictate hair pigmentation.

The study was published in the June 11, 2011 issue of the journal Cell. The research was led by Mayumi Ito, PhD, assistant professor in the Ronald O. Pereleman Department of Dermatology at NYU Langone.

“We have known for decades that hair follicle stem cells and pigment-producing melanocycte cells collaborate to produce colored hair, but the underlying reasons were unknown,” said Dr. Ito. “We discovered Wnt signaling is essential for coordinated actions of these two stem cell lineages and critical for hair pigmentation.”


The study suggests the manipulation of Wnt signaling may be a novel strategy for targeting pigmentation such as graying hair. The research study also illustrates a model for tissue regeneration.

“The human body has many types of stem cells that have the potential to regenerate other organs,” said Dr. Ito. “The methods behind communication between stem cells of hair and color during hair replacement may give us important clues to regenerate complex organs containing many different types of cells.”

Using genetic mouse models, researchers were able to examine how Wnt signaling pathways enabled both hair follicle stem cells and melanocyte stem cells to work together to generate hair growth and produce hair color. Research also showed the depletion (or inhibition or abnormal) Wnt signaling in hair follicle stem cells not only inhibits hair re-growth but also prevents melanocytes stem cell activation required for producing hair color. The lack of Wnt activation in melanocyte stem cells leads to depigmented or gray hair.

The study raises the possibility that Wnt signaling is a key pathway for the regulation of melanocyte stem cells and shows how melanocyte behavior is associated with hair regeneration.

 

]]> http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/wnt-signaling-may-end-grey-hair-baldness/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/stem-cell-injection-therapy/will-stem-cell-treatments-be-a-cure-for-hair-loss/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/stem-cell-injection-therapy/will-stem-cell-treatments-be-a-cure-for-hair-loss/#comments Thu, 19 May 2011 17:30:20 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=8590

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/stem-cell-injection-therapy/will-stem-cell-treatments-be-a-cure-for-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/hair-loss-in-korea-hair-cloning/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/hair-loss-in-korea-hair-cloning/#comments Fri, 13 May 2011 16:54:06 +0000 Paul Martin http://stemcellbaldnesscures.com/?p=7771 A study published online last October appears to show that South Korean researchers are pushing ahead on hair cloning research. The study, published in the Journal of Dermatological Science (Volume 60, Issue 2) concerns the use of mesenchymal stem cells to stimulate new hair growth. The stem cells used in the study were derived from bone marrow and umbilical cord sources.

“We isolated and cultivated MSCs from bone marrow and umbilical cord in vitro,” the study authors reported. “After propagated MSCs underwent preconditioning in dermal papilla forming medium (DPFM), then subcultured MSCs formed self-aggregated DPLTs. We compared real human scalp dermal papilla cells (hDPCs) with DPLTs employing DPCs, DPLTs employing hBM-MSCs and DPLTs employing hUC-MSCs.”


Rough translation: The stem cells were able to produce hair-like structures similar to ordinary scalp hairs.

“The DPLTs have the same hair bulb structure inductive ability as natural DPLTs in vitro,” the authors write. “Transplanted DPLTs can induce new hair follicle in athymic mice. As a result, UC-MSCs and BM-MSCs may be an applicable and novel cell source for the generation of human hair cell therapy.”

Of course, no practical therapy has been created as a result of this study. As always, “more research” — and funding! — is needed. But it shows that the Koreans have started investigating hair cloning in a serious way.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/hair-loss-in-korea-hair-cloning/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-2/hair-loss-what-research-has-shown-causes-hair-loss/ http://stemcellbaldnesscures.com/hair-loss-hair-2/hair-loss-what-research-has-shown-causes-hair-loss/#comments Fri, 25 Feb 2011 01:12:21 +0000 Susan Thompson http://stemcellbaldnesscures.com/?p=9385 When we think of hair loss issues, we automatically picture balding middle-aged men.

During the first medical study of hair loss, there were 100 participants of Middle Eastern and Italian decent. Of those 100, 99 were men and 1 was a woman. Researchers were operating on a theory that balding was a genetic disorder that was more predominant in some nationalities than others were. All bonding was diagnosed as alopecia. This has changed over the years.

This study confirmed for the first time that genetics did have a major part in alopecia. Today, the hair loss related to inherited causes is called androgenetic alopecia. You probably hear this referred to as male pattern balding. The study also revealed that these genes did not occur solely along the lines of nationality. Additionally, the myth that this disorder followed the lines of the paternal grandmother was dispelled.

At the time, hair loss in women and children was largely dismissed as stress or traumatic events. When researchers did take note that such conditions existed more readily than believed, a few studies were undertaken to determine the causes. Due to the findings of the first study with the one female participant, the assumption was held that all baldness was due to inherited factors. Keep in mind, this was before the ability to test for DNA.


In more recent years, a new approach was taken at the University of Pennsylvania. Doctors studied how hair actually grows. For the first time, they established that the follicles exhibited growing and resting cycles. During the resting cycles in some instances would shrink while in other cases, they would expand. The follicles that shrunk did not produce healthy hair roots and the hairs that did grow would be very fine. From these studies, it was deduced that alopecia was caused by this shrinkage.

Simultaneously, more women became medical researchers and began investigating the reasons behind female hair loss and thinning. Wondering if it had the same root cause. The second phase of their study included whether the treatments used for men was effective for women. In the course of their projects, these researchers stumbled upon several other causes for balding in both men and women.

Additional causes of hair loss include diabetes, medications for chronic illness, severe chronic illness and childbirth. Other substantiated causes – especially in children – id related to severe stress or long-term anxiety. In some cases, the hair does not regrow on its own. Hair loss in men, women and children requires diagnosis before appropriate treatment methods are tried.

]]> http://stemcellbaldnesscures.com/hair-loss-hair-2/hair-loss-what-research-has-shown-causes-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/growth-serum-2/new-growth-serum-for-hair-loss/ http://stemcellbaldnesscures.com/growth-serum-2/new-growth-serum-for-hair-loss/#comments Sat, 19 Feb 2011 20:48:07 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=9371 What if I told you that there is actually HOPE for a stem cell technology that actually grows NEW hair… new hair that, unlike that produced by some drugs, actually lasts?

Well, many of our readers know about Follica, Histogen and other companies that are attempting to develop practical hair growth serums using stem cells. We’ve all heard the promises… and we’ve all seen the countless delays. We launched this website to follow these developments…and we’ve grown increasingly frustrated by the delays.

Dr. George Costarellis of the University of Pennsylvania Medical School discovered that stem cells could actually be reprogrammed to regenerate hair follicles through a process similar to what happens in wound healing. He set up a company, Follica, that is attempting to develop a commercial application of his discovery… but after several years, nothing has happened yet.

Another company in San Diego, Histogen, has received a gob of funding and is farther along in producing a practical treatment. Its Hair Stimulating Complex (HRC) is a proprietary blend of hair growth factors, taken from stem cells, that it says will be an injectible hair growth serum. Again, there have been promising reports but nothing concrete yet… Delay, delay, delay.

Well, here’s the news. More than a year ago, we were approached by a doctor who has developed a topical stem cell product that, he claims, is producing results far beyond those reported by other companies — and it’s a topical hair growth serum, not an injectible one.

And get this: The newest version will finally be available in a matter of a few WEEKS!

The bad news is that it takes MONTHS to work… and it’s expensive. The cost is around $299 for a five month supply or around $60 a month.

But here’s the GOOD news: It apparently works! According to the doctor who has developed this (who I have NOT revealed before), the clinical results so far are:

Grow New Hair Starting Right Now

• Hair Thickness: Improved by 33%
• Hair Length: Improved by 58%
• Hair Strength (Tension): Improved by 61%
• Hair Loss Prevention: Improved 72%
• Scalp Rejuvenation: Improved 58%
• Overall Growth: Improved 41%

This doctor has been losing his hair for 40 years and has worn a hair piece for 27 years. Yet to his astonishment, he is growing NEW hair again. And unlike many drug-based solutions, which must be continually applied or the “peach fuzz” quickly disappears, the new hair lasts.

I am so excited by this I can barely sit still!

We will be reporting on this new breakthrough in detail over the coming several weeks. They are producing 1,000 boxes of the new serum in the first batch… and they will launch a website to take advanced orders in a week or two. I know they will sell out in a matter of HOURS. That’s why we’ve reserved 200 boxes for our subscribers and will sell them to whomever wants them on a first come, first served basis.

Anyway, I just thought I’d let you know that some exciting developments are happening. The big companies are proceeding at a snail’s pace… but individual physicians and hair growth specialists are taking action on their own, in private labs. They are building on the recent discoveries and developing new hair growth serums that could be the breakthrough we’ve all been looking for.

If you’d like more information on this exciting new hair growth serum, fill in the form below…

Best wishes,

Julian

]]> http://stemcellbaldnesscures.com/growth-serum-2/new-growth-serum-for-hair-loss/feed/ 0 http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/tampa-bay-man-tries-experimental-stem-cell-hair-replacement/ http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/tampa-bay-man-tries-experimental-stem-cell-hair-replacement/#comments Thu, 03 Sep 2009 00:48:16 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=1431 A Tampa Bay area TV station did a story recently on a man undergoing a highly experimental stem cell treatment for hair replacement. The man, Russell Gibson, had the treatment at the Hair and Scalp Clinics located at 13555 Automobile Boulevard #110 in Clearwater, Florida.

“This treatment involves drawing the blood of the patient, their own blood,” explained the clinic’s medical director, John Satino. “It’s then separated. It’s called PRP or Platelet Rich Plasma which contains stem cells and growth factors.”

Satino added that those growth factors then are injected into the scalp in the affected area. Satino said that a laser is used to “agitate” the skin so the stem cells can migrate into the hair follicles.

John Satino says if you’re losing your hair there are several other treatment options available but first he recommends patients who are losing their hair take a DNA test. It’s a simple mouth swab taken to determine whether you have male pattern baldness. It costs about 100 dollars and you can see your lab results online before following up with a doctor.

He adds that injections of cortisones or steroids can work for some but may only have temporary results. Laser treatments are another option that may work and then there’s the stem cell treatment which is the procedure Russell Gibson is undergoing.

]]> http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/tampa-bay-man-tries-experimental-stem-cell-hair-replacement/feed/ 0 http://stemcellbaldnesscures.com/cloning/hair-cloning-cloning/scientists-discover-signal-that-turns-hair-growth-cells-back-on/ http://stemcellbaldnesscures.com/cloning/hair-cloning-cloning/scientists-discover-signal-that-turns-hair-growth-cells-back-on/#comments Fri, 15 May 2009 18:37:11 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=9659 Science Daily reports that scientists from Rockefeller University and the Howard Hughes Institute have identified the signaling molecule that ratchets up and clamps down the activity of key genes in dermal papilla, a type of skin cell whose unique collection of proteins ultimately instruct epithelial stem cells to make hair.

The research, which was published in Genes & Development, highlights how this signaling molecule, a protein called BMP, is crucial for the future reprogramming of hair follicles.

Epithelial stem cells nest in the upper portion of the adult hair follicle, and dermal papilla reside nearby in the mesenchymal layer below them. It is thought that the communication signals between the two cell types instruct the stem cells to form hair follicles during embryogenesis, and then, when these follicles have matured, regulate their cycles of hair growth and regeneration.

“Scientists don’t know how dermal papilla cells are programmed to provide the instructive signals to stem cells, but now we know that BMP signals play a crucial role,” says Michael Rendl, who conducted this work while he was a postdoc in Elaine Fuchs’s Laboratory of Mammalian Cell Biology and Development.

For several years, it has been known that BMP signaling must be reduced in order to activate follicle stem cells. “Michael has now uncovered a new twist to the story,” says Fuchs, who is Rebecca C. Lancefield Professor at Rockefeller and an investigator at the Howard Hughes Medical Institute, “namely that dermal papilla cells appear to receive BMP signals from their surrounding microenvironment and this signaling is required for these two cell types to maintain cross talk.”

Fuchs conducted the study with Rendl, who found that BMP6, a member of the BMP family of proteins, orchestrates dermal papilla’s signature genes to turn on and off, thereby giving these skin cells their unique collection of proteins and features.

Fuchs’s team developed a clever strategy to delete several genes in vitro, ones that encode for the receptor onto which several BMPs bind. They then grafted these genetically engineered dermal papilla cells onto the backs of bald mice to see if these mice would grow hair.

Well, the mice didn’t. When dermal papilla cells lacked this receptor, their signature proteins were not expressed and the key signaling that occurs between epithelial stem cells and dermal papilla was impaired. Without this exchange, the hair follicles did not grow or make hair.

Nearly all of the signature proteins that Rendl and Fuchs tested in dermal papilla cells decreased when they deleted the BMP receptor. The exception: BMP6 itself. This increase in BMP6 expression levels suggests that BMP6 is necessary for both locking in dermal papilla’s molecular identity as well as maintaining the crosstalk that allows stem cells to receive hair-inducing signals, but it itself is not the signal that stem cells await. This finding also provides clues to the type of signals that follicle stem cells may send to dermal papilla.

What’s more, BMP6 specifically maintains the molecular identity of dermal papilla cells. When Rendl and Fuchs induced the BMP pathway in other cell types that respond to BMP signaling, they found that these cells continue to produce the normal amount of their signature proteins. “This was really interesting,” says Rendl. “It is likely the case that different signaling pathways, or a combination of them, regulate different sets of genes to give each cell type in the hair follicle its characteristic properties.”

Fuchs speculates that “this complex circuitry in BMP signaling may set the foundations for a BMP regulatory clock that drives the hair cycle. If so, we may be one step closer to unlocking nature’s secrets to hair growth.”

This research was supported in part by the Tri-Institutional Stem Cell Initiative, a collaborative program of three New York City biomedical research institutions — Memorial Sloan-Kettering Cancer Center, The Rockefeller University and Weill Cornell Medical College.

]]> http://stemcellbaldnesscures.com/cloning/hair-cloning-cloning/scientists-discover-signal-that-turns-hair-growth-cells-back-on/feed/ 0 http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/dermal-papilla-dp-cells/the-mysterious-hair-growth-and-hair-treatment-technology-of-dr-gho/ http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/dermal-papilla-dp-cells/the-mysterious-hair-growth-and-hair-treatment-technology-of-dr-gho/#comments Fri, 01 May 2009 23:53:45 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=34 Anyone concerned with hair growth, hair cloning, alopecia, hair treatment and so on is probably familiar with the controversial work of Dr. Coen Gho, a Dutch medical doctor and dermatologist who has been a pioneer in efforts to develop practical hair regrowth treatments for male pattern baldness and alopecia.

Dr. Gho’s research has been followed closely by numerous experts in the field of hair transplantation and rejuvenation. He has been criticized, however, for not submitting his research to the rigorous scrutiny of peer-reviewed scientific journals.

Throughout the 1990s, Dr. Gho developed specialized techniques of hair follicle extraction and transplantion. The GHO Clinic was established in 1994 with offices at various places around the world, with head offices in Prague. In 2005, Dr. Gho resigned from the GHO Clinic and launched a new venture, The Hair Science Institute (HSI), located at the World Trade Center in Amsterdam.

According to HSI’s own website, the technology that Dr. Gho has developed — which he terms “HairStemcell Transplantation” (HST) — differs from other types of hair restoration techniques in that it does not redistribute existing hair but “ensures that your own hair generates new hairs in a desired area.”

One of the transplantation techniques Dr. Gho developed – the Follicular Multiplication – was established as a restorative method to treat burn wounds. In the clinical facilities of Hair Science Institute, this method has alleged been improved and is now refined to the advanced and patented technique that is now known as HairStemcell Transplantation.

Apparently, the way the technology works is that hairs from a patient are removed from the back of the head and then analyzed. Only those hairs with particular characteristics (bigger bulb size, shape and strong pigmentation) are used for cloning purposes. Then, epithelial cells from these hair bulbs are propagated in vitro in a specialized culture medium (serum-free keratinocyte culture media with antibiotics and growth factors, such as EGF). Once these cells have propagated, they are removed from the culture and injected into skin pores of the balding area. This procedure is carried out with the aid of special needles or injectors. According to HSI, Dr. Gho’s method differs from other hair cloning techniques, such as Follicular Unit Extraction (FUE) or Follicular Multiplication (FM) techniques. Dr. Gho’s clinic insists that the Hair Science Institute approach is the most sophisticated of all attempts to transplant hair follicle by follicle. In FUE, HSI says, the whole follicle is removed with a needle of 0.75 to 1.0 mm diameter (0.45 – 0.8 mm), which results, HSI claims, in a considerable likelihood of scarring and a minimum re-growth of the removed hair.

The Follicular Multiplication (FM) technique attempts to remove only the upper part of the hair follicle with the help of a much smaller needle measuring only 0.7 mm in diameter (0.4 mm). Because of this the chance of scarring is less but re-growth is still limited. With Dr. Gho’s HairStemcell Transplantation (HST) method, the company claims, a part of the follicle is taken away in a longitudinal direction with a smaller needle still, just 0.5 mm or 0.6 mm diameter (0.2 – 0.3 mm_). This results in almost no chance of scarring and, most important of all, the re-growth of hair in the donor area is higher than with the other two methods. The company’s website has some very frank photographs of patients immediately before, during and one-day after treatment. How does Dr. Gho’s technique compare with the approaches being developed by companies such as Aderans and Intercytex? In an online interview in 2005, Dr. Gho insisted that his technology is based on the follicular stem cells and not on the Dermal Papilla cells. “In my opinion, these cells [Derma Papilla cells] are able to produce a hair; however, after a period, they will die and will not produce a hair again,” he told the interviewer. “Even Colin Jahoda revealed in his studies that human Dermal Papilla cells cannot produce a hair but an outer root sheath…”

]]> http://stemcellbaldnesscures.com/hair-loss-hair-hair-loss-hair/hair-loss-in/dermal-papilla-dp-cells/the-mysterious-hair-growth-and-hair-treatment-technology-of-dr-gho/feed/ 0 http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/stem-cell-technique-to-clone-hair-may-help-hair-loss-sufferers/ http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/stem-cell-technique-to-clone-hair-may-help-hair-loss-sufferers/#comments Fri, 01 May 2009 15:50:08 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=54

New stem cell techniques to clone hair may help hair loss sufferers, a number of scientists claimed this past week.  The combination of breakthroughs in stem cell technology and recent discoveries in the genetics of hair loss could result in a major breakthrough in the treatment of hair loss, they said.

In a recent stem cell study of hair loss led by Viljar Jaks of Sweden’s Karolinska Institute, scientists examined mouse hair follicles for signs of rapid hair growth. They discovered a protein, called Lgr5, on the surface of long-lived, active stem cells in hair cells. Apparently, cells carrying the Lgr5 marker were capable of maintaining hair follicles for as long as 14 months, the researchers said.

While still in the early stages, these recent discoveries could prove crucial in the ongoing push to develop a stem cell technique to clone hair and cure hair loss. The most likely treatment may end up being stopping hair loss before it develops into male pattern baldness. “Early prediction before hair loss starts may lead to some interesting therapies that are more effective than treating late-stage hair loss,” said Tim Spector, a researcher in Kings College London who led a related study of the DNA of hair loss.


The average person has about 100,000 scalp hairs. While most people experience some hair loss as they age, men suffering from pattern hair loss – a genetic condition inherited from parents — can suffer from significant hair loss.

Hair loss or baldness is caused by a gradual shrinking of hair follicles on top of the head. Eventually, they sprout less and less hair. Balding men and some women have follicles that shrink so much they stop producing hair at all.

In the past two years, however, the hope has arisen that it might be possible to stimulate new hair growth when a University of Pennsylvania researcher discovered that mice healing from wounds can produce brand new hair follicles. In 2007, the researcher, Dr. George Cotsarelis, showed that when skin is damaged, the skin cells behave like a stem cell and generate new hair follicles.

]]> http://stemcellbaldnesscures.com/hair-treatment-for-hair-loss/prevent-hair-loss-hair/stem-cell-technique-to-clone-hair-may-help-hair-loss-sufferers/feed/ 0 http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/stem-cell-hair-growth-serums/ http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/stem-cell-hair-growth-serums/#comments Wed, 16 Apr 2008 23:01:51 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=9523 http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/stem-cell-hair-growth-serums/feed/ 0 http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/advanced-therapeutics/ http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/advanced-therapeutics/#comments Wed, 16 Apr 2008 22:53:37 +0000 Julian Phillips http://stemcellbaldnesscures.com/?p=9517 http://stemcellbaldnesscures.com/stem-cell-hair-regrowth-2/advanced-therapeutics/feed/ 0 http://stemcellbaldnesscures.com/stem-cell-hair/looksmart/ http://stemcellbaldnesscures.com/stem-cell-hair/looksmart/#comments Sat, 03 Feb 2007 02:45:17 +0000 Julian Phillips http://stemcellbaldnesscures.com/stem-cell-hair/looksmart/

Dear Friend,

Hello. My name is Julian Phillips. Some friends and I started StemCellBaldnessCures.com back in 2008 when the first news reports appeared about new stem cell treatments for hair loss (see the video above).

At the time, it seemed as though the scientists were on the brink of a “cure” for baldness. Since then, we’ve learned that, while the initial research that gave rise to those reports was real and truly revolutionary, the way to a practical, commercial treatment is littered with obstacles.

One of the companies that started the research into stem cell treatments for hair loss, Intercytex, went out of business two years later… and another, Histogen, has been involved in court disputes over its technologies that have dragged on for years.

Yet the research is continuing… and is FINALLY beginning to bear fruit.

One of the companies that has been involved in stem cell research for hair loss is Aderans Research, and it is currently deep in its Phase II clinical trials for its new hair cloning technology that, if it works, could result in virtually limitless amounts of donor hair follicles being available for patients.

This website is dedicated to tracking these developments — and other new technologies and treatments for slowing and reversing hair loss in both men and women. Feel free to browse the links on this site for more information about stem cell and other advance treatments for hair loss, or sign up for our 12-part email course below, where you’ll receive one update per day in your email box.

In this FREE mini-course, you’ll Learn:

The breakthrough discovery about hair follicles that is fueling million-dollar research projects…

The 7 steps you can take, right now, to slow hair loss and perhaps even reverse it…

The differences between stem cell treatments, hair cloning, hair multiplication and follicular unit transfer…

What the government isn’t telling you about hair loss drugs that can leave men permanently impotent…

The #1 problem for hair transplant physicians — and why a new technology may eliminate it forever…

What teenage boys can do to stop a receding hairline before it’s too late to reverse it…

Why so many women suffer from thinning hair — and 4 new treatments designed just for them…

 

Just LOOK At What These Subscribers Say About Our Stem Cell Baldness Cures Email Updates!

“Julian, Thank you for the informative and encouraging study on the use of the different hair treatments for women. I began using one treatment about 4 years ago and decided after 3 months to begin using a stronger formulation.  I was encouraged to continue because it was obvious there was less shedding and increased hair growth. There was the accompanying itchiness and occasional burning with the use of certain hair products…ie: shampoos, etc. I have heard that this treatment stops working after about 3 years and your growth/loss cycles cease to be effective. Do you know if that is true? I had a compounding pharmacy formulate a special product for me w/o propylene glycol and have began using that. There is still the accompanying itchiness. They can formulate it for me with some topical steroid (cortisone) to help with the itchiness and irritation but I’m not a big fan of steroids. It is in a glycerine base. Anyway, thanks again. I always look forward to your emails and am grateful for your information.” - A.C., London

“Julian, I just wanted to send you thanks for the constant updates. For people who are selfconscious about their appearance, these constant updates are great and I would say give hope that they will eventually cure MPB. I did have a question, though. I got an update from you a few months ago, Aderans and Recoverup. These where two treatment options i was very interested in. I send recoverup an email and they said that do to the events that took place in japan they shut down temporarily. Do you know of any options like this that are available to the general consumer and if so what would be the best way to approach it? As always, thank you much, Erik”

“Hey Julian, Just a quick note to let you know that I appreciated this article. It is comforting to know that I’m not the only one who is “throwing everything in the tackle box”. Cheers, Randy”

“HI Julian, Thanks for your emails. I want to know if some of these treatments will be of any benefit for female androngenic hair loss.  I am 52 years old and started to lose my hair in my early teens.  My hair is thin, very fine and oily. I am also very concerned for my 19 year old daughter her hair is getting thinner and  has got fine in texture.  I am rather resistant to taking drugs especially taking into consideration how young my daughter is. Thankk you for all your help. Margaret, Omaha”  

Stay Informed!  Learn Everything You Need to Know About the Very Latest Stem Cell and Other Advanced Treatments for Hair Loss!

Sign Up for Your Free Email Updates Now

       Sincerely,

 

 

Julian Phillips
Webmaster

Additional Articles
Stem Cell for Hair Loss: Dr. Coen Gho Pioneers Patented Hair Follicle Multiplication and Hair Growth Technologies
Baldness Cure: Replicel Develops Hair Loss Treatment for Cue Ball Heads!
How to Hair Growth for 2012: 7 Steps to Take Right Now
Bald Women: What to Do About Female Hair Loss

]]> http://stemcellbaldnesscures.com/stem-cell-hair/looksmart/feed/ 0 http://stemcellbaldnesscures.com/stem-cell-hair/7search/ http://stemcellbaldnesscures.com/stem-cell-hair/7search/#comments Sat, 03 Feb 2007 02:17:00 +0000 Julian Phillips http://stemcellbaldnesscures.com/stem-cell-hair/7search/

Dear Friend,

Hello. My name is Julian Phillips. Some friends and I started StemCellBaldnessCures.com back in 2008 when the first news reports appeared about new stem cell treatments for hair loss (see the video above).

At the time, it seemed as though the scientists were on the brink of a “cure” for baldness. Since then, we’ve learned that, while the initial research that gave rise to those reports was real and truly revolutionary, the way to a practical, commercial treatment is littered with obstacles.

One of the companies that started the research into stem cell treatments for hair loss, Intercytex, went out of business two years later… and another, Histogen, has been involved in court disputes over its technologies that have dragged on for years.

Yet the research is continuing… and is FINALLY beginning to bear fruit.

One of the companies that has been involved in stem cell research for hair loss is Aderans Research, and it is currently deep in its Phase II clinical trials for its new hair cloning technology that, if it works, could result in virtually limitless amounts of donor hair follicles being available for patients.

This website is dedicated to tracking these developments — and other new technologies and treatments for slowing and reversing hair loss in both men and women. Feel free to browse the links on this site for more information about stem cell and other advance treatments for hair loss, or sign up for our 12-part email course below, where you’ll receive one update per day in your email box.

In this FREE mini-course, you’ll Learn:

The breakthrough discovery about hair follicles that is fueling million-dollar research projects…

The 7 steps you can take, right now, to slow hair loss and perhaps even reverse it…

The differences between stem cell treatments, hair cloning, hair multiplication and follicular unit transfer…

What the government isn’t telling you about hair loss drugs that can leave men permanently impotent…

The #1 problem for hair transplant physicians — and why a new technology may eliminate it forever…

What teenage boys can do to stop a receding hairline before it’s too late to reverse it…

Why so many women suffer from thinning hair — and 4 new treatments designed just for them…

 

Just LOOK At What These Subscribers Say About Our Stem Cell Baldness Cures Email Updates!

“Julian, Thank you for the informative and encouraging study on the use of the different hair treatments for women. I began using one treatment about 4 years ago and decided after 3 months to begin using a stronger formulation.  I was encouraged to continue because it was obvious there was less shedding and increased hair growth. There was the accompanying itchiness and occasional burning with the use of certain hair products…ie: shampoos, etc. I have heard that this treatment stops working after about 3 years and your growth/loss cycles cease to be effective. Do you know if that is true? I had a compounding pharmacy formulate a special product for me w/o propylene glycol and have began using that. There is still the accompanying itchiness. They can formulate it for me with some topical steroid (cortisone) to help with the itchiness and irritation but I’m not a big fan of steroids. It is in a glycerine base. Anyway, thanks again. I always look forward to your emails and am grateful for your information.” - A.C., London

“Julian, I just wanted to send you thanks for the constant updates. For people who are selfconscious about their appearance, these constant updates are great and I would say give hope that they will eventually cure MPB. I did have a question, though. I got an update from you a few months ago, Aderans and Recoverup. These where two treatment options i was very interested in. I send recoverup an email and they said that do to the events that took place in japan they shut down temporarily. Do you know of any options like this that are available to the general consumer and if so what would be the best way to approach it? As always, thank you much, Erik”

“Hey Julian, Just a quick note to let you know that I appreciated this article. It is comforting to know that I’m not the only one who is “throwing everything in the tackle box”. Cheers, Randy”

“HI Julian, Thanks for your emails. I want to know if some of these treatments will be of any benefit for female androngenic hair loss.  I am 52 years old and started to lose my hair in my early teens.  My hair is thin, very fine and oily. I am also very concerned for my 19 year old daughter her hair is getting thinner and  has got fine in texture.  I am rather resistant to taking drugs especially taking into consideration how young my daughter is. Thankk you for all your help. Margaret, Omaha”  

Stay Informed!  Learn Everything You Need to Know About the Very Latest Stem Cell and Other Advanced Treatments for Hair Loss!

Sign Up for Your Free Email Updates Now

       Sincerely,

 

 

Julian Phillips
Webmaster

Additional Articles
Stem Cell for Hair Loss: Dr. Coen Gho Pioneers Patented Hair Follicle Multiplication and Hair Growth Technologies
Baldness Cure: Replicel Develops Hair Loss Treatment for Cue Ball Heads!
How to Hair Growth for 2012: 7 Steps to Take Right Now
Bald Women: What to Do About Female Hair Loss

]]> http://stemcellbaldnesscures.com/stem-cell-hair/7search/feed/ 0